Atsekardol

Atsekardol – the non-steroidal anti-inflammatory drug possessing antiagregantny action.

Form of release and structure

Drug is produced in the form of round tablets of a biconvex form, coated white color.

1 tablet contains:

• Active agent: acetylsalicylic acid (ASK) – 50, 100 or 300 mg;
• Auxiliary components: lactose, titanium dioxide, magnesium stearate, castor oil, microcrystallic cellulose, povidone, corn starch.

Indications to use

Atsekardol appoint at unstable stenocardia, and also for prevention of the following diseases:

• Acute and repeated myocardial infarction with such risk factors as a lipidemia, a diabetes mellitus, obesity, advanced age, smoking, arterial hypertension;
• Thromboembolism in the postoperative period and at invasive interventions on vessels (for example, endarterectomy and angioplasty of carotid arteries, shunting aortocoronary and arteriovenous);
• Stroke (including to patients with passing disturbance of blood circulation of a brain);
• Deep vein thrombosis and thromboembolism of branches of a pulmonary artery (for example, at a long-term immobilization owing to surgical intervention).

Contraindications

• Gastrointestinal bleeding and erosive cankers of a GIT;
• Bronchial asthma and Fernán-Vidal's triad (combination of intolerance of ASK recuring a polypose of a nose and okolonosovy bosoms and bronchial asthma);
• Hemorrhagic diathesis;
• Hypersensitivity to ASK or auxiliary components of drug;
• I and III trimesters of pregnancy;
• Lactation period (feedings by a breast);
• Combination with a methotrexate in a dosage from 15 mg a week and above;
• Age up to 18 years.

Atsekardol it is necessary to apply with care:

• Hyperuricemia;
• Gout;
• II trimester of pregnancy;
• Combination to a methotrexate in a dosage to 15 mg a week;
• Existence in the anamnesis of disturbances of functions of kidneys and liver, GIT cankers, polypose of a nose, diseases of a respiratory organs of chronic character, bronchial asthma, hay fever.

Route of administration and dosage

Atsekardol accept inside before food, washing down with enough water. Drug is intended for prolonged use.

For the purpose of prevention of a thromboembolism of a pulmonary artery and a deep vein thrombosis, and also at suspicion of an acute myocardial infarction the daily dosage of Atsekardol makes 100 mg, or on 300 mg every other day.

At unstable stenocardia, and also for prevention of a repeated myocardial infarction, a stroke and tromboembolic postoperative episodes the minimum dosage of drug makes from 100 to 300 mg a day.

Side effects

Atsekardol's use can cause the following by-effects:

• From a respiratory organs: bronchospasm;
• From TsNS: sonitus, decrease in hearing, dizziness, headache;
• From system of a hemopoiesis: anemia, the increased probability of bleedings;
• From a GIT: heartburn, vomiting, nausea, ulcer of a 12-perstny gut, ulcer of a mucous membrane of a stomach, bleeding gastrointestinal, abnormal liver function;
• Allergic reactions: skin itch, rash, small tortoiseshell, rhinitis, Quincke's edema, acute anaphylaxis.

Special instructions

In the I trimester of pregnancy the use of high doses of salicylates is capable to increase the frequency of development of defects in a fruit, in particular heart diseases and the split sky. In the last trimester of pregnancy use of a high dosage of drug slows down patrimonial activity, causes premature closing of an arterial channel in the child, increases probability of bleeding at mother and a fruit. Atsekardol's use just before childbirth can cause intracraneal hemorrhage, especially in the premature child. In this regard Atsekardol's appointment in I and III trimesters of pregnancy is contraindicated.

In the II trimester of pregnancy drug is appointed only taking into account strict assessment of advantage and risk.

During a course of treatment it is necessary to be careful at management of transport and work with difficult mechanisms.

Analogs

Structural analogs of Atsekardol are Trombo's drugs of ASS, Aspirin, Kardiopirin, Aspinat, Aspikor, Taspir, Trombopol, Acetylsalicylic acid.

Conditions and periods of storage

To store at a temperature not above 25 °C.

Period of validity – 3 years.