Aksetin – generation cephalosporin II, the antibiotic of a broad spectrum of activity having antimicrobic and bactericidal effect.
Dosage form – powder for preparation of solution for intravenous and intramuscular administration: from white till light yellow color (in glass bottles, 1 bottle in a pack of cardboard or 100 bottles in a box cardboard (for hospitals)).
Active agent: tsefuroksy (in the form of sodium salt) in 1 bottle – 750 or 1500 mg.
Aksetin use for therapy of the following infectious and inflammatory diseases caused by microorganisms, sensitive to a tsefuroksim:
Use of drug for prevention of infectious complications at surgical interventions on bodies of a basin, an abdominal cavity, thorax, joints is recommended, including at gullet, heart, lungs operations, at orthopedic operations, and also in vascular surgery with high risk of infectious complications.
Aksetin is strictly contraindicated only at hypersensitivity to his components, other cephalosporins, karbapenema or penicillin.
Drug should be used with care in the following cases:
The solution prepared from powder enter intravenously (in/in) or intramusculary (in oil).
The adult usually appoint 750 mg 3 times a day, at the heavy course of an infectious disease the dose is increased up to 1500 mg by 3-4 times a day (an interval if necessary reduce till 6 o'clock). The average daily dose makes 3000-6000 mg.
To children 3 years usually are more senior appoint on 30-100 mg/kg/days in 3-4 receptions. The daily dose of 60 mg/kg in most cases is optimum.
To newborns and children up to 3 years – on 30 kg/kg/days in 2-3 receptions.
The recommended dosing modes:
At a chronic renal failure the dose is adjusted depending on the clearance of creatinine (CC): KK of 10-20 ml/minute – on 750 mg 2 times a day, KK less than 10 ml/minute – on 750 mg of 1 times a day.
To patients who are on a continuous hemodialysis using the arteriovenous shunt or on haemo filtering of high speed in intensive care unit appoint 750 mg 2 times a day. To the patients who are on haemo filtering of low speed appoint doses which apply at a renal failure.
At patients in whose anamnesis allergic reactions to penicillin were noted hypersensitivity to tsefalosporinovy antibiotics is possible.
During treatment it is necessary to control functions of kidneys, especially at patients who receive Aksetin in high doses. At the infections caused by Streptococcus pyogenes, treatment should be continued within 48-72 hours after disappearance of symptoms of a disease. The recommended therapy duration – not less than 10 days.
If during treatment tsefuroksimy there is a need to determine glucose level in blood, it is necessary to apply tests with a hexokinase or glucose oxydas.
At children during therapy of meningitis decrease in hearing is possible.
At use of a tsefuroksim receiving false positive reaction of urine to glucose and false positive forward reaction of Koombs is possible.
At transfer of the patient with parenteral administration Aksetin into administration of drug containing tsefuroksy inside it is necessary to consider the general condition of the patient, sensitivity of microorganisms and weight of an infection. If in 3 days after reception of means inside clinical improvement is not noted, it is necessary to continue parenteral administration.
During treatment it is not necessary to take alcoholic beverages.
Tsefuroksim pharmaceutical is compatible to the following means: xylitol, азлоциллин, the metronidazole, aqueous solutions containing to 1% of lidocaine of a hydrochloride, 5% solution of a dextrose, 0,9% solution of sodium of chloride, 4% solution of a dextrose and 0,18% solution of sodium of chloride, 5% solution of a dextrose and 0,45% solution of sodium of chloride, 10% solution of a dextrose, 5% solution of a dextrose and 0,225% chloride sodium solution, Ringer's solution, Hartman's solution, solution of sodium lactate, 5% solution of a dextrose and a hydrocortisone, 10% the inverted sugar in water for injections, potassium chloride (10 ¼Ý¬ó/l and 40 ¼Ý¬ó/l) in 0,9% chloride sodium solution, heparin (10 units/ml and 50 units/ml) in 0,9% chloride sodium solution.
Tsefuroksim pharmaceutical is incompatible with solution of sodium of bicarbonate of 2,74% and aminoglycosides.
The drugs reducing acidity of a gastric juice reduce absorption and bioavailability of a tsefuroksim.
At simultaneous use of aminoglycosides and diuretics the risk of emergence of nephrotoxic effects increases.
At simultaneous use of peroral loopback diuretics concentration in plasma increases and the elimination half-life of a tsefuroksim increases, there is a delay of canalicular secretion, the renal clearance decreases.
To store in the unavailable to children, protected from light, dry place at a temperature up to 25 ºС.
Period of validity – 2 years.
The solution prepared from powder is allowed to be stored within 48 hours in the refrigerator and within 7 hours – at the room temperature. For storage time solution can turn yellow, it is not a contraindication to its use.
The most rare disease – a disease the Kura. Only representatives of the tribe Faure in New Guinea are ill it. The patient dies of laughter. It is considered that eating of a human brain is an origin of a disease.
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