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B Amphotericinum – an antifungal antibiotic medicine of a broad spectrum of activity.
Amphotericinum of B is released in the following forms:
Excipients as a part of ointment: liquid paraffin, polysorbate 80, medical vaseline.
Active agent B Amphotericinum depending on sensitivity of the activator and concentration in biological liquids has fungistatic or fungicidal effect.
Drug is active concerning mushrooms of the sort Fonsecaea, Cryptococcus neoformans, Candida, Histoplasma capsulatum, Coccidioides immitans, Aspergillus, Sporothrix schenckii, Blastomyces dermatitidis, and also leyshmaniye.
Inhalation and parenteral use Amphotericinum of B is shown:
Ointment Amphotericinum of B is appointed at treatment of candidiasis of skin and mucous membranes.
Use Amphotericinum of B is contraindicated at the following diseases:
The question of prescription of medicine to the feeding and pregnant women is solved the doctor individually taking into account assessment of possible advantage and harm for health of mother and the child.
Before intravenous administration Amphotericinum of B establish the exact weight of the patient and calculate a necessary dose at the rate of 250 PIECES/kg. For definition of individual portability at first enter 100 PIECES/kg, and in the absence of side effects gradually increase a dose to 1000 PIECES/kg.
In order to avoid cumulation the medicine is entered by 1-2 times a week or every other day.
Duration of a medical course is defined by weight and localization of a disease, and, as a rule, makes not less than 1-2 months. The general course dose of a medicine – 1,5-2 mln units, in a month repeat treatment.
Inhalations carry out 1-2 times a day 15-20 minutes on 10 ml on the procedure that corresponds to a daily dose of 1000-2000 PIECES/kg of body weight of the patient. Treatment duration – 10-14 days, in a week it is possible to repeat a course.
Solution is prepared just before use, dissolving bottle contents in number of 50 000 PIECES in 10 ml of water for injections.
Ointment Amphotericinum of B is applied a thin layer on affected areas of skin by 2-4 times a day. The medical course depends on indications:
External use B Amphotericinum in the form of ointment can cause a pricking, dryness, burning and erubescence.
At inhalation and parenteral use of a medicine there can be nausea, pain in epigastriums, deterioration in appetite and sight, vomiting, a leukopenia, anemia, a headache, a diplopia, polyneuropathy, arrhythmia, hypertensia, an azotemia, a hypopotassemia, a proteinuria, acidosis, an itch, rash, a Quincke's edema, a bronchospasm, contact allergic dermatitis, cold, irritation in a throat, cough, a fever, temperature increase.
Therapy Amphotericinum of B needs to be stopped at development of anemia.
Ointment under occlusive bandages should not be applied.
During treatment it is necessary to control systematically a pattern of peripheral blood, function of kidneys and a liver.
If in 1-2 weeks effect of use Amphotericinum of B is insufficient, it is necessary to see a doctor behind specification of the scheme of treatment.
Analogs B Amphotericinum on the mechanism of action are such drugs as Ambiz, Amfoglyukamin, Amfotsil, Amfolip.
B Amphotericinum in all dosage forms is released on doctor's orders. A lyophilisate period of validity – 4 years, ointments – 2 years (on condition of their storage taking into account recommendations of the producer: lyophilisate – at a temperature of 2-10 °C, ointment – to 4 °C).
Name of drug
Amphotericinum B lyophilisate for infusions 50000ED of 1 piece
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