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Acetylsalicylic acid is medicine with expressed antiinflammatory, febrifugal, anesthetizing and antiagregantny (reduces process of adhesion of thrombocytes) effect.
The mechanism of effect of acetylsalicylic acid is caused by its ability to interfere with synthesis of prostaglandins playing a major role in development of inflammatory processes, fevers and pains.
Reduction of number of prostaglandins in the center of thermal control leads to vasodilatation and increase of sweating that causes febrifugal effect of drug. Besides, use of acetylsalicylic acid allows to reduce sensitivity of nerve terminations to pain mediators due to reduction of influence of prostaglandins by them. At intake the maximum concentration of acetylsalicylic acid in blood can be observed in 10-20 minutes, and the salicylate formed as a result of metabolism – in 0,3-2 hours. Acetylsalicylic acid through kidneys, an elimination half-life – 20 minutes, an elimination half-life for salicylate – 2 hours is removed.
Acetylsalicylic acid to which indications are caused by its properties is appointed at:
Tablets acetylsalicylic acid are intended for use inside, it is recommended to accept after food, washing down with milk, usual or alkaline mineral water.
The instruction recommends to apply the adult acetylsalicylic acid 3-4 times a day on 1-2 tablets (500-1000 mg), at the same time the maximum daily dose – 6 tablets (3 g). The maximum duration of use of acetylsalicylic acid – 14 days.
For the purpose of improvement of rheological properties of blood, and also as inhibitor of pasting of thrombocytes appoint ½ tablets of acetylsalicylic acid a day for several months. At a myocardial infarction and for prevention of a secondary myocardial infarction the instruction to acetylsalicylic acid recommends to accept 250 mg a day. Dynamic disturbances of cerebral circulation and cerebral thromboembolisms assume reception ½ tablets of acetylsalicylic acid with gradual bringing a dose to 2 tablets in days.
Acetylsalicylic acid to children is appointed in the following single doses: 2 years – 100 mg, the 3rd year of life – 150 mg, four-year-old – 200 mg are more senior, 5 years – 250 mg are more senior. It is recommended to accept acetylsalicylic acid to children 3-4 times a day.
Acetylsalicylic acid, use it has to be stipulated with the doctor, can provoke such side effects as:
Acetylsalicylic acid is not appointed at:
Acetylsalicylic acid is contraindicated to children 15 years at ORZ caused by viral infections, to the feeding patients, and also pregnant women in the first and third trimester are younger.
Even if use of drug is assumed by indications, acetylsalicylic acid is not appointed at hypersensitivity to it or other salicylates.
According to the instruction, acetylsalicylic acid cannot be stored in the place where air temperature can rise above 25 °C. In the dry place and at the room temperature drug will be suitable within 4 years.
Name of drug
Acetylsalicylic acid of a tablet 500 of mg of 10 pieces
Acetylsalicylic acid of a tablet 500 of mg of 20 pieces
Acetylsalicylic acid of a tablet 500 of mg of 20 pieces
Acetylsalicylic acid of a tablet 500 of mg of 20 pieces
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