Gliformin

Gliformin – peroral hypoglycemic means.

Form of release and structure

Dosage form:

• Tablets: ploskotsilindrichesky with dividing risky and a facet, white or almost white color (on 10 pieces in a blister strip packaging, in a cardboard pack of 6 packagings);
• Tablets in a film cover: color, white or white with a grayish or cream shade, biconvex, an oval form (on 60 pieces in polyethylene or polypropylene banks, in a cardboard pack of 1 bank).

The operating component – Metforminum a hydrochloride:

• 1 tablet – 0,5 g;
• 1 tablet in a film cover – 0,85 g or 1 g.

Excipients:

• Tablets: calcium stearate or stearic acid, sorbitol, povidone (polyvinylpirrolidone), phosphate calcium dihydrate, macrogoal (polyethyleneglycol);
• Tablets in a film cover: povidone, potato starch, stearic acid.

Structure of a film cover: macrogoal (polyethyleneglycol 6000), gipromelloz (gidroksipropilmetiltsellyuloz), talc.

Indications to use

Gliformin apply at treatment of a diabetes mellitus of the 2nd type as monotherapy or in combination with other hypoglycemic drugs at inefficiency of a dietotherapy, especially at patients with obesity.

Contraindications

• Diabetic prekoma, coma;
• Laktatsidoz, including in the anamnesis;
• Diabetic ketoacidosis;
• Functional disturbances of a liver and/or kidneys;
• The acute diseases capable to cause development of a renal failure: serious infectious diseases; dehydration caused by vomiting and/or diarrhea; fever; conditions of a hypoxia at bronchopulmonary diseases, sepsis, renal infections, shock;
• The serious injuries and surgeries demanding insulin therapy use;
• Reception of tablets after 48 hours to and before 48 hours after carrying out X-ray or radio isotope inspections with use of the contrast intravascular agent containing iodine;
• The fabric hypoxia caused by acute and chronic diseases including acute myocardial infarction, respiratory or heart failure, acute disorder of cerebral circulation;
• Acute alcoholic poisoning, alcoholism;
• Hypocaloric diet with energy value to 1000 kcal a day;
• Period of pregnancy and breastfeeding;
• The age is more senior than 60 years, in case of performance of heavy exercise stresses;
• Hypersensitivity to drug components.

Route of administration and dosage

Pill is taken inside during meal or right after, without chewing, washing down with enough water.

The doctor appoints dosing and the period of reception individually, considering the level of concentration of glucose in blood.

In an initiation of treatment, the first 10-15 days, the dose can make from 0,5 to 1 g of 1 times a day, then, depending on sugar level in blood, it can be increased gradually. The maintenance dose, as a rule, makes 1,5-2 g a day divided into 2-3 receptions.

The maximum daily dose – 3 g.

For patients of advanced age the most admissible amount of drug – 1 g a day.

In case of considerable disturbances of metabolic processes the dose is recommended to be lowered as the risk of development of a laktatsidoz increases.

Side effects

• From endocrine system: in case of overdose – a hypoglycemia;
• From the alimentary system: lack of appetite, an abdominal pain, nausea, metal smack in a mouth, diarrhea, vomiting, a meteorism (these symptoms are characteristic to start treatment, then the state is normalized);
• From system of a hemopoiesis: sometimes – megaloblastny anemia;
• From a metabolism: at prolonged treatment – _B12 hypovitaminosis, in rare instances – лактацидоз;
• Allergic reactions: skin rash.

At emergence of side effects it is necessary to cancel temporarily drug and to see a doctor.

Special instructions

Treatment needs to be accompanied with regular control of level of glucose in blood.

During therapy each half a year it is necessary to conduct researches on determination of level of a lactate and creatinine in a blood plasma. Function of kidneys is especially carefully recommended to be controlled at patients of advanced age. Men cannot appoint drug at creatinine level higher than 135 µmol/l, to women – 110 µmol/l.

Side effects from the alimentary system can be reduced a concomitant use of antacids or spasmolysants.

During treatment it is necessary to refrain from the alcohol intake and means containing ethanol.

At monotherapy drug does not influence ability to control of motor transport and work with mechanisms.

At a concomitant use of Gliformin, including with insulin, sulphonylurea derivatives, it is necessary to be careful with other hypoglycemic means at control of vehicles and performance of potentially dangerous types of activity demanding the high speed of psychomotor reactions and special attention.

Medicinal interaction

Strengthening of effect of drug at simultaneous use with the insulin, beta adrenoblockers derivative of sulphonylurea, non-steroidal anti-inflammatory drugs, acarbose, monoamine oxidase inhibitors, inhibitors of an angiotensin-converting enzyme, Oxytetracyclinum, cyclophosphamide, Clofibratum derivatives is possible.

Gliformin's action can decrease at simultaneous use with the glucagon, glucocorticosteroids, oral contraceptives, hormones of a thyroid gland, Epinephrinum, sympathomimetics, "loopback" and thiazide diuretics derivative of niacin and a fenotiazin.

The concomitant use of etanolsoderzhashchy means can cause development of a laktatsidoz.

Removal of drug is slowed down at a combination to Cimetidinum, the probability of development of lactic acidosis increases.

At a concomitant use with the anticoagulants derivative of coumarin, their action decreases.

Terms and storage conditions

To store in the protected from light, dry place at a temperature up to 25 °C. To protect from children.

Period of validity: tablets – 3 years, tablets in a film cover – 2 years.