Goldlayn

Goldlayn is one of drugs for treatment of obesity, registered in Russia since 2009. This medicine is made by the RANBAXY LABORATORIES Ltd company. (Bulgaria). Active ingredient in Goldlayna is сибутрамин, as well as in some other medicines – Reduksin, Lindaks, Meridiya. Drug is released in drugstores according to the recipe of the doctor. Even if you have an opportunity to get medicine without appointment of the doctor (for example, in an Internet drugstore), strictly it is not recommended to begin treatment with this serious drug without consultation of the specialist.

Structure of tablets Goldlayn and form of production of drug

Medicine is issued in the form of capsules on 15 mg of a sibutramin of a hydrochloride of monohydrate. Excipients: lactose, cellulose microcrystallic, silicon dioxide colloid, magnesium stearate. In a pack there can be 10 or 30 capsules.

Pharmacological action

Tablets Goldlayn are drug of the central action. Sibutramin who is their part inhibits the return capture of mediators of serotonin and noradrenaline in a brain. These substances – so-called "hormones of happiness". Their increased concentration reduce appetite, food requirement and promote more bystry saturation. Also сибутрамин increases thermoproducts that raises an expense of calories an organism.

Goldlayn's pharmacokinetics

After intake Goldlayn is well soaked up from digestive tract. Not less than 77% of active ingredient get to blood. Further Goldlayn is exposed to biotransformation in a liver where gets the active form in the form of metabolites. The maximum concentration of drug in blood is reached in 1,2 hours, and its active metabolites – in 3-4 hours. The concomitant use of medicine and food reduces the maximum concentration by 30% and slows down time of its approach for 3 hours. Goldlayn is quickly distributed on all body tissues. It well contacts proteins of a blood plasma (94-97%). In 4 days of regular use of tablets concentration in plasma reaches peak and exceeds similar value after a single dose of Goldlayn twice. Thus, the maximum effect of drug comes only after several days of treatment. Active ingredient of tablets Goldlayn is removed generally by kidneys. In 14-16 hours from the reception moment concentration of active metabolites in a blood plasma falls twice. Traces of drug are found in an organism within several days after phase-out of tablets.

Indications to use

Doctors appoint Goldlayn for weight loss. Use of drug is proved in the presence of the excess body weight or obesity. The body weight index (Quetelet's index) has to be more than 27 kg/m ². The increased body weight at the same time has to be connected with the alimentary and constitutional reasons, that is heredity, a way of life, food. Other reasons of obesity (genetic syndromes, endocrinological diseases, pathology of the central nervous system) Goldlayn do not treat.

Contraindications to use

This medicine has a set of contraindications and therefore it has to be appointed the doctor and only after careful inspection. So, Goldlayn for weight loss it is impossible to accept if the patient has organic reasons of obesity (a hypothyroidism, a prolaktinoma), nervous bulimia, mental diseases, alcoholism, drug addiction, disturbances of cerebral circulation, a heart trouble and vessels, arrhythmia, uncontrollable arterial hypertension, a pheochromocytoma, a thyrotoxicosis, prostate adenoma, closed-angle glaucoma, serious illnesses of kidneys or a liver. Children cannot take a pill Goldlayn up to 18 years and to elderly patients 65 years, and also to pregnant women and nursing mothers are more senior. It is impossible to drink at the same time Goldlayn and other drugs for weight loss of the central action, and also the drugs influencing the central nervous system (antidepressants, anticonvulsant), monoamine oxidase inhibitors, tryptophane. If the allergy to a sibutramin or excipients of drug is established, then Goldlayn do not appoint.

Dosing mode

Goldlayn appoint in 1 times a day. Medicine should be taken in the morning, regardless of food, having washed down with a glass of water. The maximum dose of drug of 15 mg a day. Duration of therapy should not be more than 2 years. If in 3 months of treatment the effect unsatisfactory, then drug is cancelled. Goldlayn's use for weight loss has to be only in a combination to a diet and an exercise stress. The experienced doctor (endocrinologist) has to control treatment.

Goldlayn by-effects

Within the first month of use of Goldlayn development of side effects is the most probable. Eventually expressiveness of these phenomena weakens. From the central nervous system sleeplessness, headaches, dizziness, uneasiness are possible. From cardiovascular system a cardiopalmus, increase in arterial pressure, erubescence are sometimes observed. From digestive tract appetite loss, locks, nausea, change of flavoring feelings are possible dryness in a mouth. Sometimes there is an increased sweating, a skin itch. Rather seldom after the termination of treatment reaction to Goldlayn's cancellation – the increased appetite, a headache develops. In isolated cases also other by-effects are recorded.

Goldlayn storage conditions

Medicine has to is in the place, unavailable to children. At a temperature up to 25 degrees drug is good within two years from the date of production.

Special instructions

At the women of childbearing age accepting Goldlayn has to at the same time careful contraception is carried out.

To each patient receiving Goldlayn, a minimum of times in two weeks arterial pressure has to be measured. At values more than 145/90 mm Hg Goldlayn cancel. Also count heart rate. At rest it has to be to 90 beats per minute.

Goldlayn can affect ability to manage motor transport and mechanisms.

Responses

Reviews of Goldlayna of doctors (endocrinologists and therapists) in general positive. Its high performance is noted. Usually medicine is appointed the sick obesity inclined to an overeating of carbohydrates, bulimias. Drug is tried to be appointed with care only to people of young age without serious chronic illnesses. Such vigilance is caused by what in many countries сибутрамин is prohibited because of risk of death of patients from a heart attack or a stroke, and also a suicide. Similar risks were revealed during enough long controlled researches. In Russia since 2008 substance is included into officially approved list of strong drugs.

In reviews of Goldlayna of patients high performance of drug is noted. Patients like a sharp loss of appetite, the raised mood background, working capacity, cheerfulness which they connect with administration of drug. In negative responses speak about side effects: to hypertensia and sleeplessness.