Ibuprofen

Ibuprofen – the nonsteroid synthetic drug possessing analgeziruyushchy, antiinflammatory and febrifugal action.

Pharmacological action

Active ingredient of drug – an ibuprofen, derivative fenilpropionovy acid.

The ibuprofen is most effective at pains of inflammatory character. On febrifugal action it is rather close to acetylsalicylic acid. Suppresses pasting of thrombocytes, improves microcirculation and reduces intensity of an inflammation.

At external use the Ibuprofen in the form of ointment has the strong anesthetizing action, reducing a hyperemia, morning constraint and hypostasis.

Drug is carried to the list of the major medicines of World Health Organization, its efficiency and safety is studied and clinically approved.

Release form

The ibuprofen is released in the form of tablets, by suspensions and ointments.

• The tablets Ibuprofen – round, smooth, biconvex white color. Each tablet contains 200 mg or 400 mg of active ingredient. Excipients – magnesium stearate, talc, lactose, potato starch, silicon dioxide colloid, Povidone 25. On 10, 20 and 100 pieces in packaging;
• Coated tablets of the Ibuprofen of the prolonged action. Each tablet contains 800 mg of active ingredient. On 7, 14 and 60 pieces in packaging;
• Tablets for a rassasyvaniye. Each tablet contains 200 mg of active ingredient;
• Capsules of the prolonged action. Each capsule contains 300 mg of active ingredient;
• Suspension the Ibuprofen for intake homogeneous, yellow, with an orange smell. 5 ml of suspension contain 100 mg of active ingredient. Produce in bottles 100 ml, in cardboard packaging with a measured spoon;
• 5% cream and gel for external use.

Indications to use of the Ibuprofen

The ibuprofen is shown at:

• Symptomatic treatment of flu and SARS;
• Osteoarthrosis;
• Psoriasis arthritis;
• Cervical spondylosis;
• Barret-Lyeu's syndrome;
• Cervical migraine;
• Bursitis;
• Bekhterev's diseases;
• Neuralgic amyotrophy;
• Mialgiya;
• Nephrotic syndrome;
• Postural hypotension (at reception of antihypertensives);
• Feverish states various etymologies;
• Traumatic inflammations of soft tissues and musculoskeletal system;
• Syndrome of a vertebral artery;
• Neuralgia;
• Tendinitis;
• Hematomas.

Also the Ibuprofen is shown at treatment of stretchings of the copular device, a pseudorheumatism, radiculitis and a joint syndrome (at an exacerbation of gout).

As supportive application the Ibuprofen is shown to use at:

• Pneumonia;
• Postoperative, tooth and headache;
• Infectious and inflammatory LOR-diseases – pharyngitis, tonsillitis, rhinitis, laryngitis, sinusitis;
• Bronchitis;
• Panniculitis;
• To primary dysmenorrhea;
• Algodismenory;
• Inflammatory processes in a small basin;
• Adnexitis.

Contraindications

The ibuprofen according to the instruction is contraindicated at:

• Hypersensitivity to drug;
• Aggravation of a peptic ulcer of a stomach or duodenum and ulcer colitis;
• Diseases of an optic nerve and disturbance of color sight;
• Aspirinova to asthma;
• Arterial hypertension;
• To scotoma;
• Amblyopias;
• The expressed renal failures or liver, and also at cirrhosis with portal hypertensia;
• Heart failure;
• Hypostases;
• Hemophilias;
• Hypocoagulations;
• Leukopenias;
• Pathologies of a vestibular mechanism;
• Deficit glyukozo-6-fosfatdegidrogenazy;
• III trimester of pregnancy.

According to the instruction the Ibuprofen is appointed with care at:

• Chronic heart failure,
• Associated diseases of a liver and kidneys,
• Enteritis;
• Right after carrying out surgeries;
• At dispeptic symptoms before an initiation of treatment;
• Gastritis;
• Prick;
• Children's age up to 12 years.

At use of the Ibuprofen it is necessary to carry out systematic control of a picture of peripheral blood, and also functions of a liver and kidneys.

Application instruction of the Ibuprofen

According to the instruction the Ibuprofen is accepted after food inside.

The daily dose of drug depends on a disease:

• At an osteoarthrosis, algodismenory, psoriasis arthritis and an ankylosing spondylarthritis the adult appoint 400-600 mg 3-4 times a day;
• At a pseudorheumatism accept the increased dose, on 800 mg 3 times a day;
• At injuries of soft tissues and stretchings apply tablets of the Ibuprofen of the prolonged action - 1600-2400 mg once a day, better before going to bed;
• At a moderate pain syndrome accept 1200 mg a day;
• At the feverish syndrome which arose after immunization apply 50 mg, if necessary reception can be repeated in 6 hours, but no more than 100 mg a day.

At feverish states to children 12 years for decrease in body temperature a dose of the Ibuprofen are more senior calculate:

• It is higher than 39.2 hail. With – 10 mg on 1 kg of weight a day;
• It is lower than 39.2 hail. With – 5 mg on 1 kg of weight a day.

The tablets Ibuprofen for a rassasyvaniye are applied to treatment the ENT SPECIALIST of diseases, rassasyvy in a mouth under language. To children 12 years are more senior and the adult appoint 200–400 mg 2–3 times a day.

Suspension for intake is usually appointed to children. The average single dose at reception on 3 times a day makes:

• From 1 to 3 years – 100 mg;
• From 4 to 6 years – 150 mg;
• From 7 to 9 years – 200 mg;
• From 10 to 12 years – 300 mg.

Outwardly apply gel or cream the Ibuprofen, putting and rubbing it before full absorption on area of defeat 3-4 times a day. Treatment can be carried out within 2-3 weeks.

Side effects

According to the instruction the Ibuprofen – rather safe drug is also usually transferred well. At use some side effects can be observed:

Alimentary system: there are diarrhea, vomiting, nausea, anorexia, a sensation of discomfort in epigastriums, digestive tract erosive cankers more often; much more rare than an abnormal liver function or bleeding from digestive tract.

Nervous system: there can be a headache or dizziness, sleep disorders or excitement, and also vision disorders.

Circulatory system: side effects are observed only at prolonged use of drug – thrombocytopenia, anemia, an agranulocytosis.

Urinary system: renal failures can arise at prolonged use of the Ibuprofen.

Allergic reactions can be observed both at administration of drug inside, and at external use in the form of erubescence, skin rash, a Quincke's edema, a burning sensation. There are a bronkhospastichesky syndrome and aseptic meningitis much less often.

The ibuprofen is contraindicated in the III trimester of pregnancy. Use in I and II trimesters is perhaps strict according to testimonies of the doctor.

In the period of a lactation it is possible to apply the Ibuprofen in low doses at pains and fever. As drug is emitted in breast milk use in doses over 800 mg a day contraindicated.

Storage conditions

The ibuprofen is released according to the recipe of the doctor. A period of storage – 3 years.