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Pyrantelum

Препарат Пирантел. "Vishpha" Украина


Producer: "Vishpha" Ukraine

Code of automatic telephone exchange: P02CC01

Release form: Liquid dosage forms. Suspension oral.

Indications to use: Enterobiosis. Ascaridosis. Ankilostomidoz. Necatoriasis.


General characteristics. Structure:

Active ingredient: 5 ml of suspension oral contain Pyrantelum of a pamoat (in terms of Pyrantelum) 250 mg.

Excipients: sorbite solution which does not crystallize (supports E 420); glycerin; polysorbate 80; sodium carboxymethylcellulose; Natrium benzoicum (Е 211); aluminum-magnesium silicate; povidone; симетикон; Apricot of MA/1 137 fragrance (contains propylene glycol); citric acid monohydrate; sodium hydroxide; the water purified.

Suspension of light yellow color with a characteristic smell. At storage stratification which is eliminated at agitation is possible.




Pharmacological properties:

Pharmacodynamics. The depolarizing action of Pyrantelum causes development of the neyromuskulyarny block therefore there is a spasm of muscles of helminth, and the last leaves from an organism an intestines peristaltics. PIRANTEL-VISHFA affects both on puberal, and immature individuals of parasites.

Pharmacokinetics. Pyrantelum памоат it is badly soaked up from digestive tract (less than 3,8%). After reception internally in a dose of 10 mg/kg concentration in plasma represents 0,005 - 1,13 mkg/ml within 1 - 3 hours. The minimum quantity of drug is partially metabolized in a liver to N - methyl - 1,3 pro-pan-diamines. More than 50% of drug are allocated in not changed view with a stake after reception internally, no more than 7% are removed with urine in not changed look and in the form of N - methyl - 1,3 pro-pan-diamines.


Indications to use:

Enterobiosis, ascaridosis, анкилостомидоз, necatoriasis. 


Route of administration and doses:

Apply orally, in time or after food. There is no need to apply purgatives or to abstain from acceptance of food. Before use shake up before receiving homogeneous suspension.

The recommended drug dose for adults and children makes 10 mg of active agent on 1 kg of body weight. The maximum dose - 1000 mg internally disposable.

Depending on age and body weight appoint:

- to children aged from 6 months up to 2 years - 125 mg (2,5 ml);

- from 2 to 6 years - 250 mg (5 ml);

- from 6 to 12 years - 500 mg (10 ml);

- 12 years and the adult with body weight to 75 kg - 750 mg (15 ml) are more senior;

- the adult with body weight more than 75 kg - 1000 mg (20 ml) of 1 times a day.

At treatment of an enterobiosis for the purpose of improvement of effect accurate observance of rules of personal hygiene (especially to children) and repeated administration of drug in 2-3 weeks after previous is recommended.

At severe forms of a dochmiasis appoint a double dose? 20 mg on kilogram of body weight in 1 or 2 receptions within 2-3 days.


Features of use:

With care appoint the patient with an abnormal liver function. After drug use purgatives are not appointed. At an enterobiosis it is necessary to carry out simultaneous treatment of all persons who live in one room with the patient. After the termination of a course of treatment it is necessary to conduct control laboratory researches (analyses a calla on presence of parasites).

Drug can entail dizziness, drowsiness and weakness therefore it is necessary to apply with care during control of vehicles and work with other mechanisms.

Use during pregnancy or feeding by a breast. In pilot studies of teratogenic effects it is not established. Use during pregnancy and feeding груддю is possible if the expected advantage for mother exceeds possible risk for the fruit/child.

Children. Do not apply to children aged up to 6 months.


Side effects:

From the alimentary system: nausea, vomiting, pain in an epigastra, anorexia, spasms in a stomach, tenesmus, diarrhea, it is rare - increase in activity of hepatic transaminases.

From the central and peripheral nervous system: headache, dizziness, feeling of fatigue, drowsiness, sleeplessness.

From integuments: allergic rashes.


Interaction with other medicines:

It is not recommended to use drug together with levamisole (potentiation of toxicity of the last) and with piperazin which is an antagonist of protivogelmintny action of Pyrantelum. Drug can increase concentration of theophylline.


Contraindications:

Hypersensitivity to drug components; disturbance of functions of a liver; period of pregnancy and feeding by a breast; children's age up to 6 months.


Overdose:

Anorexia, nausea, vomiting, diarrhea, ataxy, however in connection with the minimum quantities of Pyrantelum is possible that they are absorbed, even the considerable overdose causes symptoms of intoxication very seldom. Due to the lack of a specific antidote in cases of reception of an overdose of drug the symptomatic treatment (gastric lavages, purgatives), in case of need – a maintenance therapy is recommended by cordial and analeptical means. 


Storage conditions:

To store at a temperature not over 25 ºС in the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

On 15 ml in a bottle with a measured spoon in a pack.



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