Sodium chloride

General characteristics. Structure:

Pharmacological properties:

Has disintoxication and regidratiruyushchy effect. Fills shortage of sodium at various morbid conditions of an organism and temporarily increases the volume of the liquid circulating in vessels.

Pharmacokinetics. It is quickly removed by kidneys without changes.

Indications to use:

Isotonic solution of sodium of chloride is applied to dissolution of medicines, and also at big losses of extracellular liquid or its insufficient receipt (toxic dyspepsia, cholera, diarrhea, pernicious vomiting, extensive burns with strong exudation, etc.), a hypochloraemia and a hyponatremia with dehydration, intestinal impassability, intoxications, to washing of wounds, eyes, a mucous membrane of a nose, to partial perfusion together with heparin, antineoplastic and other medicines.

 

Route of administration and doses:

Isotonic solution of sodium of chloride for infusions is entered intravenously (usually kapelno), subcutaneously, rektalno or locally (for washing of wounds, eyes, a mucous membrane of a nasal cavity), for moistening of a dressing material.

Before introduction solution is heated to 36-38 °C. The dose is defined depending on loss by an organism of liquid, ions of sodium and chlorine - averages 1000 ml/days. At big losses of liquid and the expressed intoxication introduction to 3000 ml/days is possible. Rate of administering - 540 ml/h (180 caps/min.); if necessary - rate of administering is increased.

To children at the expressed lowering of arterial pressure against the background of dehydration (before determination of laboratory parameters) enter 20-30 ml/kg. Further the mode of dosing is adjusted depending on laboratory indicators.

Features of use:

At long introduction of high doses of isotonic solution of sodium of chloride it is necessary to carry out control of an acid-base state and electrolytes in a blood plasma and urine.

At considerable dehydration at impossibility of intravenous administration enter subcutaneously or rektalno.

Side effects:

Introduction of large volumes of isotonic solution of sodium of chloride can lead to chloride acidosis and an overhydratation, and also to a hypopotassemia.

Interaction with other medicines:

Let's combine with colloid hemodynamic blood substitutes (mutual strengthening of effect).

When mixing with other medicines it is necessary to control compatibility visually.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypopotassemia, extracellular overhydratation, the circulator disturbances menacing with wet brain and lungs, wet brain, a fluid lungs, an acute left ventricular failure, the accompanying purpose of glucocorticosteroids in high doses.

With care: dekompensirovanny chronic heart failure, chronic renal failure (oligo-anury).

Use during pregnancy and in the period of a lactation
Data are absent.

Storage conditions:

Period of validity: 2 years. Not to use after expiry date.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions of 0,9% on 250, 500 ml in containers polymeric for infusion solutions of single use on TU 9444-01-14795782-2006. Containers pack into a bag from a polyethylene film or polyethylene - polyamide films. For hospitals: containers on 250 ml stack 24 pieces in a box from corrugated fibreboard. Put 24 application instructions in each box. Containers on 500 ml stack 12 pieces in a box from corrugated fibreboard. Put 12 application instructions in each box.