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medicalmeds.eu Medicines Synthetic spasmolysants. Papaverine derivatives. Drotaverinum hydrochloride

Drotaverinum hydrochloride

Препарат Дротаверина гидрохлорид. РУП "Белмедпрепараты" Республика Беларусь



General characteristics. Structure:

Active ingredient: 40 mg of Drotaverinum of a hydrochloride in 1 tablet.

Excipients: povidone - K-25, lactoses monohydrate, talc, calcium stearate, potato starch.

Drotaverinum the hydrochloride renders spasmolytic, myotropic, vasodilating, hypotensive action.




Pharmacological properties:

Pharmacodynamics. Reduces intake of the ionized active calcium in smooth muscle cells at the expense of inhibition of phosphodiesterase and intracellular accumulation of tsAMF. Has the expressed and long effect on smooth muscles of internals and vessels, causes a moderate lowering of arterial pressure, increases the minute volume of heart, has some antiarrhytmic effect. Reduces a tone of vessels of a brain and increases their krovenapolneniye. Practically does not influence the autonomic nervous system and does not get into TsNS.

Pharmacokinetics. It is quickly and fully soaked up in digestive tract. Bioavailability makes about 100%. The period of semi-absorption is equal to 12 min. It is evenly distributed on fabrics, gets into smooth muscle cells. Drotaverinum contacts proteins of plasma for 95 — 98%. It is excreted preferential by kidneys.


Indications to use:

The spasm of smooth muscles of internals (kardio-and a pylorospasm), chronic gastroduodenit, a peptic ulcer of a stomach and duodenum, cholelithiasis (hepatic colic), chronic cholecystitis, a postcholecystectomy syndrome, hyper motor dyskinesia of bilious ways, spastic dyskinesia of intestines, intestinal colic owing to a delay of gases after operation, colitis, a proctitis, tenesmus, a meteorism, an urolithiasis (renal colic), a pyelitis, a vasospasm of a brain, coronary and peripheral arteries, need of weakening of reductions of a uterus and a spasmolysis of a neck of uterus at childbirth, a spasm of smooth muscles during tool interventions.


Route of administration and doses:

Drug is appointed inside. Accept 1 — 2 tablet (0,04 — 0,08 g) 2 — 3 times a day. To children up to 6 years appoint in a dose 0,01 — 0,02 g of 1 — 2 time a day, to children of 6 — 12 years — 0,02 g of 1 — 2 time a day.

To children 12 years are more senior appoint in a dose for adults.


Features of use:

With care apply at prostate adenoma, the expressed atherosclerosis of coronary arteries.

With care it is necessary to appoint drug at pregnancy.


Side effects:

Feeling of heat, dizziness, arrhythmias, hypotension, heartbeat, perspiration (is more often at parenteral administration), allergic dermatitis.


Interaction with other medicines:

Strengthens effect of other spasmolysants (including m-holinoblokatorov), the hypotension caused by tricyclic antidepressants, quinidine, novokainamidy.

Reliability of elimination of a spasm raises phenobarbital. Reduces spazmogenny activity of morphine, antiparkinsonichesky properties of a levodopa.


Contraindications:

Hypersensitivity, glaucoma.


Overdose:

AV blockade, cardiac standstill, paralysis of a respiratory center.


Storage conditions:

In the place protected from moisture and light at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 2 years. Not to use after the period of validity specified on packaging.


Issue conditions:

Without recipe


Packaging:

Tablets of 40 mg in a blister strip packaging No. 10х1, No. 10х2.



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