Chronic idiopathic small tortoiseshell

Description:

One of clinical options of a small tortoiseshell.

Symptoms of the Chronic idiopathic small tortoiseshell:

Chronic small tortoiseshell is characterized by periodic aggravations which last more than 6 weeks. During aggravations the Quincke's edema can be observed. For the rest clinical displays of chronic and acute urticaria are identical.
The diagnosis of "an idiopathic small tortoiseshell" is exposed in that case when it is not possible to establish the reason of its emergence. Earlier was considered that a small tortoiseshell in most cases is idiopathic and makes 80-95% of all cases of a small tortoiseshell. For the last decade there was a considerable shift in understanding of an etiology, pathogeny and mechanisms of development of this disease. In foreign literature of the last years the name "idiopathic small tortoiseshell" meets more and more seldom, the term "chronic small tortoiseshell" became more widespread. It is not accidental as in the course of long-term observation of patients with earlier established diagnosis "an idiopathic small tortoiseshell" by many researchers revealed autoimmune genesis of a disease. It is shown that at a chronic small tortoiseshell in serum of patients autoantibodies to high-affine receptors on mast cells are defined. These autoantibodies have ability to directly cause degranulation of mast cells.

Reasons of the Chronic idiopathic small tortoiseshell:

The disease has the autoimmune nature.

Treatment of the Chronic idiopathic small tortoiseshell:

In most cases means of the first choice in treatment of patients with a chronic small tortoiseshell consider antihistaminic drugs. They influence H1-histamine receptors of post-capillary venules of skin, thereby eliminating the vazodilatation and increase in permeability of vessels induced by a histamine.