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medicalmeds.eu Medicines Immunomodulators. Groprinosin

Groprinosin

Препарат Гроприносин. Gedeon Richter (Гедеон Рихтер) Венгрия


Producer: Gedeon Richter (Gideon Richter) Hungary

Code of automatic telephone exchange: J05AX05

Release form: Firm dosage forms. Tablets.

Indications to use: Subacute sclerosing panencephalitis. Genital herpes. Immunodeficiency.


General characteristics. Structure:

Active agent: Inosine пранобекс 500 mg

Excipients: Starch of potato 85 mg, Polyvinylpirrolidone of 45 mg, Magnesium stearate of 10 mg.




Pharmacological properties:

Pharmacodynamics. The immunostimulating drug with antiviral action. Represents the complex containing inosine and VD-dimetilamino-2-propanol in a molar ratio 1:3. Efficiency of a complex is defined by inosine presence, the second component increases its availability to lymphocytes. Groprinosin stimulates biochemical processes in macrophages, increases products of interleykin, increases synthesis of antibodies, strengthens proliferation of T lymphocytes, T-helperov, natural cells killers. Stimulates hemotaksichesky and phagocytal activity of monocytes, macrophages and polymorphonuclear cells. Groprinosin suppresses DNA replication and RNA of viruses by means of linkng with a ribosome of a cell and change of its stereochemical structure.
Drug is well transferred since has a hypotoxicity. It is possible to appoint him the patient at advanced age having stenocardia or a chronic circulatory unefficiency.
At timely use of drug the frequency of developing of viral infections is reduced, duration and disease severity decreases. Use of drug is shown to patients with insufficient immune, protection. At Groprinosin's appointment as auxiliary medicine at infectious damage of mucous membranes and the skin caused by the Herpes simplex virus there is more bystry healing of the struck surface, than at treatment in the traditional way. There are new bubbles, hypostases, erosion and palindromias less often.

Pharmacokinetics. After intake drug is well soaked up from a digestive tract and shows good biological availability. In an organism quickly breaks up to metabolites and it is allocated through kidneys. Inosine is exposed to a metabolization on the cycle typical for purine nucleotides, with formation of uric acid! which level in blood serum can sometimes increase. Formation of crystals of uric acid in uric ways is as a result possible. Cumulation of drug in an organism is not revealed. Full elimination of drug and its metabolites from an organism occurs within 48 hours.


Indications to use:

- the immunodeficiency caused by viral infections in patients with the normal and weakened immune system / including the diseases caused by the Herpes simplex virus (Gui's type type II, genital herpes and herpes of other localization);
- subacute sclerosing panencephalitis.


Route of administration and doses:

Drug is appointed orally at regular intervals (8 or 6 hours) by 3-4 times a day. A pill is taken after food, washing down with a small amount of water.
If the doctor does not appoint differently, then usually accept:

- adults: from 6 to 8 tablets a day divided into 3 - 4 receptions;
- children: from 2 to 12 years: 50 mg/kg of body weight a day divided into 3 - 4 receptions;
Equally, both at adults and at children, at serious infectious diseases the dose can be increased individually under control of the doctor to 100 mg/kg of body weight a day divided into 4 - 6 receptions. Drug is usually used within 5 days, sometimes longer, depending on disease. After the 8 a day break the course of treatment can be repeated.


Features of use:

Drug should not be used at a hyperuricemia (the increased concentration of uric acid in blood) in connection with a possibility of increase in level of uric acid in blood serum and in urine. If, despite everything, drug is applied, then it is regularly necessary to carry out the analysis of level of uric acid in an organism. Patients with considerably the increased level of uric acid can accept at the same time the drugs lowering its level. Patients with an acute liver failure of a dose need to reduce since process of a metabolization of drug happens in a liver. Patients of advanced age have no need of change of a dose.
Influence on ability of control of vehicles and service of the mechanical equipment.
For the patients accepting Groprinosin there are no special contraindications concerning driving of vehicles and service of mobile mechanisms.


Side effects:

During an initial stage of treatment a loss of appetite, nausea, vomiting, diarrhea are possible; slight increase of concentration of uric acid in blood and urine; allergic reactions.


Interaction with other medicines:

Efficiency of action is reduced by immunodepressants.


Contraindications:

- gout
- urolithiasis
- giperchuvetvitelnost
- arrhythmia
- children's age up to 2 years
- period of pregnancy and feeding by a breast.

Use at pregnancy and feeding by a breast.
Drug should not be accepted at pregnancy and during feeding by a breast since safety of use is not established.


Overdose:

Data on drug overdose Groprinosin are not provided.


Storage conditions:

To store in the dry place protected from light at the room temperature not above 25 °C.
To store in the place, unavailable to children!


Issue conditions:

According to the recipe


Packaging:

On 10 tablets in the blister from PVC of a film and aluminum foil.
On 2 or 5 blisters with the application instruction in a cardboard pack.



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