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medicalmeds.eu Medicines Anticoagulating means of direct action for topical administration. Ï¿«Ô«¡® 1000 gel

Ï¿«Ô«¡® 1000 gel

Препарат Лиотон® 1000 гель . Berlin-Chemie AG/ Menarini Group (Берлин-Хеми АГ/ Менарини Групп) Германия


Producer: Berlin-Chemie AG/Menarini Group (Berlin-Hemi AG/Menarini Group) Germany

Code of automatic telephone exchange: C05BA03

Release form: Soft dosage forms. Gel.

Indications to use: Inflammatory infiltrate. Hematoma. Bruises. Periphlebitis. Thrombophlebitis. Venous insufficiency. Varicose vein disease.


General characteristics. Structure:

Active ingredient: heparin sodium salt – 100000 ME

Excipients: methylparahydroxybenzoate – 0,12 g, propilpara-hydroxybenzoate – 0,03 g, carbomer of 940 - 1,25 g, alcohol of 96% (ethanol) – 30,00 ml, neroli oil – 0,05 g, lavender oil – 0,05 g, trietanolamine (троламин) – 0,85 g, the water purified – to 100,00 g.




Pharmacological properties:

Pharmacodynamics. Heparin sodium - anticoagulant of direct action, concerns to group of middlemolecular heparins. Interferes with a thrombogenesis, activity of hyaluronidase oppresses, activates fibrinolitic properties of blood.

At external use renders local antitrombotichesky, antiedematous and antiinflammatory action, improves microblood circulation and activates fabric exchange owing to what processes of a rassasyvaniye of hematomas accelerate, formation of blood clots is prevented, puffiness of fabrics decreases.

Pharmacokinetics. At external use the insignificant amount of heparin gets into a system blood stream, without having systemic action, without causing any changes of parameters of a blood coagulation. Does not get through a placental barrier.


Indications to use:

• diseases of superficial veins: varicosity, chronic venous insufficiency and related complications (thrombophlebitis, periphlebitis);
• stupid injuries and bruises of soft tissues;
• hypodermic hematomas, including hematomas after vein operations, phlebectomies;
• the localized infiltrates and hypostases of soft tissues.


Route of administration and doses:

For external use.

1–3 times a day apply a small amount of gel (3-10 cm) with a thin layer on skin and carefully rub.

At the localized effects of injuries and bruises (a hematoma, infiltrate, hypostasis of soft tissues) to apply before disappearance of symptoms.

At initial symptoms of venous insufficiency ("weight", an onychalgia, venous hypostases) to apply within 1 - 3 weeks depending on expressiveness of symptoms.

At chronic venous insufficiency (a varicosity, a superficial periphlebitis, superficial thrombophlebitis) to apply within  4 - 6 weeks depending on expressiveness of symptoms of a disease.

Need of further treatment is defined by the doctor.


Features of use:

It is not recommended to apply on mucous membranes, open wounds and to apply in the presence of purulent defeats in an estimated site of application of gel.

At long use of the drug Лиотон® 1000 on extensive sites of skin and simultaneous use of anticoagulants of indirect action (warfarin, Syncumarum, etc.), it is necessary to control a prothrombin time and a blood clotting time.

It is not recommended to use the drug Лиотон® 1000 at a deep vein thrombosis.

Influence of drug on ability to driving of motor transport and to control of mechanisms

Ï¿«Ô«¡® 1000 does not influence ability to driving of vehicles and the work demanding the increased concentration of attention.


Side effects:

In some cases the reactions of hypersensitivity to drug components which are shown reddening and/or an itch of skin which, as a rule, take place after drug phase-out can be observed.


Interaction with other medicines:

Simultaneous use with the drugs for external use containing tetracyclines, antihistaminic or non-steroidal anti-inflammatory drugs is not recommended.


Contraindications:

• hypersensitivity to drug components;
• disturbance of integrity of integuments in a drug site of application (open wounds, ulcer and necrotic defeats);
• the increased tendency to bleeding, thrombocytopenia;
• age up to 18 years (safety and efficiency of use of drug are not studied).


Overdose:

Extremely low system absorption of active component of drug at external use makes overdose almost impossible.

In case of overdose effect of heparin can be neutralized by sulfate protamin solution.


Storage conditions:

At a temperature not above 25 °C. To store in the place, unavailable to children! Period of validity of 5 years. Not to use after expiry date of the drug specified on packaging.


Issue conditions:

Without recipe


Packaging:

Gel for external use of 1000 ME/g.

On 30 g, 50 g or 100 g of drug in the tubas made of soft aluminum, covered from within with epoxy with the screw-on cap perforator (polyethylene/polypropylene).

On 1 tuba together with the application instruction place in a cardboard pack.



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