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medicalmeds.eu Medicines The means influencing cardiovascular system. Venorutinol

Venorutinol

Препарат Венорутинол. ХФЗ ЗАО НПЦ Борщаговский Украина


Producer: HFZ CJSC NPTs Borshchagovsky Ukraina

Code of automatic telephone exchange: C05C A04

Release form: Firm dosage forms. Capsules.

Indications to use: Varicose vein disease. Periphlebitis. Diabetic mikroangiopatiya. Hemorrhoids.


General characteristics. Structure:

International name: Troxerutin; main physical and chemical properties: solid gelatin capsules with a lid and the case of yellow color, No. 0; contents of capsules – powder from yellow till brownish-yellow color, inodorous; structure: 1 capsule contains 300 mg of a trokserutin (venorutinol);
excipients: macrogoal 6000, lactose monohydrate, calcium stearate.




Pharmacological properties:

Pharmacodynamics. Trokserutin – drug with R-vitamin activity and the expressed angioprotektorny properties. Drug lowers vascular and fabric permeability and fragility of capillaries, contributes to normalization and strengthening of a trophicity of fabrics, reduces developments of stagnation in veins and paravenous sites, has antiedematous and antiinflammatory effect, raises a tone of smooth muscles of venous blood vessels. Takes part in oxidation-reduction processes; blocking activity of hyaluronidase, stabilizes activity of hyaluronic acid in a cover of cells. Increases density of a vascular wall, reducing exudation of a liquid part of plasma and emigration of uniform elements of blood. Thanks to decrease in expressiveness of an exudative inflammation in vessels, троксерутин limits sticking of thrombocytes to a surface of a vascular wall.

Pharmacokinetics. After intake drug is well absorbed from digestive tract. The maximum concentration of active agent in plasma is noted on average in 2 hours after intake. Well gets through a blood-brain barrier. It is metabolized in a liver with formation of several inactive metabolites. It is partially removed in not changed view with urine and bile.


Indications to use:

Chronic venous insufficiency; a varicosity, including at pregnancy; superficial thrombophlebitis, periphlebitis; hemorrhagic diathesis with a hyperpermeability of capillaries; capillary toxicosis (including measles, scarlet fever, flu). Diabetic mikroangiopatiya; hemorrhoids; paresthesia and spasms of the lower extremities at night and when awakening; side vascular effects of radiation therapy; after operational interventions concerning a varicosity.


Route of administration and doses:

Venorutinol accept inside during meal on 1 capsule 2 times a day (in the morning and in the evening); for a maintenance therapy – on 1 capsule a day. The course of treatment makes 3–4 weeks and longer. In more hard cases of chronic venous insufficiency (ulcers and trophic injuries of skin of a shin), at a diabetic mikroangiopatiya, a capillary toxicosis it is necessary to accept 1–2 capsules 3 times a day (for a maintenance therapy – on 1 capsule 2 times a day). At paresthesia (numbness of legs) and at night tonic spasms Venorutinol accept on 1 capsule for the night (before going to bed) and in the morning.


Features of use:

Long use of Venorutinol is not recommended to patients with the expressed renal failures. There is no experience of use of drug for treatment of children and a dosage for various age. In the I trimester of pregnancy use of kapillyarostabiliziruyushchy drugs is limited as harmlessness for a fruit is not studied; in II and in the III trimester drug is appointed only then if need of administration of drug for mother exceeds risk for a fruit (in the presence of absolute indications). During a lactation use of drug is not desirable.


Side effects:

Allergic skin reactions are in rare instances observed: urticaria, eczema, dermatitis; digestive tract erosive cankers, a headache are possible.


Interaction with other medicines:

Drug strengthens effect of ascorbic acid on permeability of capillaries.


Contraindications:

Hypersensitivity to drug; a peptic ulcer of a stomach and duodenum, chronic gastritis (in an aggravation phase).


Overdose:

Cases of overdose by Venorutinol are not known.


Storage conditions:

To store in the unavailable to children, dry, protected from light place at a temperature not above 25 °C.

Period of validity - 3 years.


Issue conditions:

Without recipe


Packaging:

On 10 capsules in a blister strip packaging. On 2 planimetric packagings in a pack.



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