Tsinarizin-LH tab.0,025 No. 50

General characteristics. Structure:

International and chemical name: cinnarizine; [(Е) - 1-difenilmetil-4-(3-phenyl-2-propenyl) - piperazin]; Main physical and chemical properties: tablets of white or almost white color. Structure: 1 tablet contains cinnarizine 0,025 g; excipients: lactoses monohydrate, potato starch, magnesium stearate, silicon dioxide colloid (aerosil), polyvinylpirrolidone low-molecular medical.

Pharmacological properties:

Pharmacokinetics. The maximum concentration in a blood plasma after intake is reached in 1–3 h at an elimination half-life about 4 hours. 91% contact proteins of a blood plasma. It is completely metabolized in a liver by means of dealkylation. 2/3 metabolites are allocated with a stake, 1/3 – with urine.

Indications to use:

Drug is used at the disturbances of cerebral circulation caused by an ischemic stroke, a vasospasm, atherosclerosis in the period of an aftercare of a hemorrhagic stroke and craniocereberal injuries, at distsirkulyatorny encephalopathy, migraine, Menyer's disease, for prevention and treatment of disturbances of peripheric circulation (an obliterating thromboangitis, a Raynaud's disease, a diabetic angiopatiya, a Crocq's disease), cerebrovascular insufficiency (dizziness, a sonitus, decrease in concentration of attention and memory), prevention of a disease of movement.

Route of administration and doses:

Drug is appointed inside after food. At disturbance of cerebral circulation of cerebrovascular insufficiency usually apply on 1 tablet (25 mg) 3 times a day or 3 tablets (75 mg) once a day. At disturbances of peripheric circulation appoint 2-3 tablets 3 times a day or 3 tablets (25 mg) once a day. If necessary before movement in any transport take 1 pill (25 mg) in 30 minutes, at vestibular frustration the dose is raised to 1 tablet (25 mg) by 3 times a day. To children the dose is reduced twice. The course of treatment makes several weeks or months.

Features of use:

It is necessary to consider drug sedation (especially in the first days of treatment) at appointment to drivers of transport and other persons whose work demands bystry mental and physical reaction. At prolonged treatment control of functions of a liver, kidneys is necessary, for peripheral blood. With care to apply at Parkinson's disease.

Side effects:

Drowsiness, weakness, fatigue, headache, dryness in a mouth, hypotension, cholestatic jaundice, the increased sweating are possible, or flat depriving of manifestation of a lupus erythematosus, the dispepsichesky phenomena, allergic reactions in the form of skin rash. At elderly people extrapyramidal symptoms, a depression appear or amplify. In such cases it is necessary to reduce a drug dose.

Interaction with other medicines:

Drug strengthens effect of sedatives, alcohol, tricyclic antidepressants, nootropic means, the means expanding vessels.

Contraindications:

Hypersensitivity to drug components. Drug is not recommended to pregnant women and in the period of a lactation.

Overdose:

Symptoms: vomiting, drowsiness, tremor, arterial hypotension, coma. Treatment: gastric lavage, purpose of absorbent carbon; symptomatic therapy. There is no specific antidote.

Storage conditions:

In the dry, protected from light place at a temperature from 15 °C to 25 °C.

Period of validity – 5 years.

Issue conditions:

Without recipe

Packaging:

On 25 tablets in blister strip packagings, on 1 or 2 blister strip packagings in a pack cardboard.