Polioksifumarin

General characteristics. Structure:

Active ingredients: 15 g of a macrogoal (polyethyleneglycol 20 000), 500 mg of potassium of iodide, 6 g of sodium of chloride, 14 g of sodium of a fumarat, 120 mg of magnesium of chloride of hexahydrate.

Excipients: water for injections.

The multifunctional plasma substituting solution of hemodynamic action with the expressed anti-hypoxemic properties balanced on ionic structure. Provides recovery of a system hemodynamics, water-salt balance, correction of a metabolic acidosis and energy balance. Drug fills the volume of the circulating blood (VCB), improves microcirculation and has antihypoxemic and diuretic effect. Polioksifumarin is safe and is well had. It is allowed for use in children's practice.

Pharmacological properties:

Pharmacodynamics. Polioksifumarin - a multifunctional blood substitute of hemodynamic action with the expressed anti-hypoxemic properties. The components providing permanent correction of a hemodynamics, a macrogoal-20000 (polyethyleneglycol-20000) are a part of drug; normalization of an acid-base state and energy balance at the cellular level (sodium fumarates (sodium fumarate)) and maintenance of stable water and electrolytic balance (ions of sodium, potassium, magnesium and chlorine).

At Polioksifumarin's use there is post-infusional hemodilution as a result of which viscosity of blood decreases and its rheological properties improve. Infusions of drug raise a diuresis, promote activation of disintoxication processes.

Pharmacokinetics. After Polioksifumarin's infusions electrolytes and fumarating completely are metabolized. The colloid basis – a macrogoal-20000 (polyethyleneglycol-20000) – is not metabolized. The main way of removal of a macrogoal-20000 (polyethyleneglycol-20000) - a kidney: 95% of a colloid after single introduction are removed with urine within 5 days, about 5% - through digestive tract in the same terms. Repeated introduction of Polioksifumarin does not lead to accumulation of a macrogoal-20000 (polyethyleneglycol - 20000) in bodies and fabrics, the organism is exempted from it by 8-14 days.

Indications to use:

Polioksifumarin apply at adults and children (since 1) at hypovolemic conditions of various origin (blood loss, shock, burns, an injury, intoxications) for the purpose of recovery of a system hemodynamics, water-salt balance, correction of a metabolic acidosis and energy balance.

Polioksifumarin apply also as a component of perfused mix to filling of the cardiopulmonary bypass.

Route of administration and doses:

Polioksifumarin apply intravenously (struyno or kapelno). Doses and rate of administering of drug should be chosen according to indications and a condition of the patient. Before use to shake up.

At shock (hemorrhagic, burn, traumatic, operational) Polioksifumarin enter the adult intravenously in a dose 400-800 ml on one introduction, to children - 15-20 ml on body weight kg. Begin administration of drug struyno, and at stabilization of arterial pressure - kapelno. In need of repeated introductions adults are allowed to administer the drug in volume to 2 l a day, and to children - to 30 ml on body weight kg.

At heavy intoxications (peritonitis, sepsis, intestinal impassability, a burn toxaemia, etc.) Polioksifumarin enter the adult intravenously kapelno in a dose 400-800 ml within 1-3 days, and to children of 15-20 ml on body weight kg a day into combinations with other disintoxication means.

At operations with use of the cardiopulmonary bypass Polioksifumarin apply as a gemodilyuent to filling of the cardiopulmonary bypass (30-40% of perfused solution).

Features of use:

With care appoint at the compensated heart failure, a chronic renal failure, pregnancy, the lactation period.

Side effects:

Side effects are not revealed, but as the iodide capable to release a histamine and other biologically active agents is a part of drug potassium, at Polioksifumarin's use for some patients with hypersensitivity to drugs of iodine the possibility of development of allergic reactions is not excluded.

Interaction with other medicines:

Polioksifumarin's use in schemes of treatment of shock assumes a possibility of administration of drug together with transfusion of donor blood, the erythrocontaining environments, plasmas, etc. blood preparations. Polioksifumarin is allowed to enter in combination with other colloid environments (Poliglyukin, Reopoliglyukin, drugs on the basis of gelatin, etc.) and crystalloid solutions (solution of sodium of chloride of 0,9%, Ringer's solution, Mafusol, etc.). Polioksifumarin's use does not interfere also with use of usually applied antishock means from among analgeziruyushchy drugs, barbiturates, tranquilizers, glucocorticosteroids, inhibitors of proteases (Aprotininum) and metabolic drugs (phosphocreatinine).

Contraindications:

Hypersensitivity to drug. States, at which contraindicated intravenous administration of large volumes of liquid; including at a craniocereberal injury, intracranial hypertensia and chronic heart failure.

Storage conditions:

At a temperature from 0 °C to 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

On 400 ml in bottles glass with a capacity of 450 ml, corked by traffic jams from rubber and rolled by aluminum caps. On each bottle paste the label from paper. The bottle together with the application instruction is placed in a pack from a cardboard. Or on 15 bottles together with not less, than 5 application instructions, pack into boxes from corrugated fibreboard (for hospitals).