Glucose

General characteristics. Structure:

Active ingredient: 400 g of a dextrose (glucose in terms of anhydrous).

Excipients: sodium chloride, Acidum hydrochloricum to pH 3-4, water for injections.

Pharmacological properties:

Pharmacodynamics. Participates in oxidation-reduction processes in an organism, improves anti-toxic function of a liver, strengthens sokratitelny activity of a cardiac muscle, covers a part of power expenses which at a number of morbid conditions go at the expense of organism stocks. Coming to fabrics, it is phosphorylated, turning into glyukozo-6-phosphate which actively joins in many links of a metabolism of an organism.

40% solution are hypertensive. Drug increases the osmotic pressure of blood, improves a metabolism, expands vessels, increases a diuresis.

Pharmacokinetics. It is acquired completely by an organism, by kidneys it is not removed (emergence in urine is a pathological sign).

Indications to use:

Hypoglycemia, insufficiency of carbohydrate food, toxicoinfection, intoxications at liver diseases (hepatitis, dystrophy and a hepatatrophia, including a liver failure), hemorrhagic diathesis; intoxication; collapse, shock.

As component of various blood-substituting and antishock liquids; for preparation of solutions of medicines for intravenous administration.

Route of administration and doses:

Intravenously kapelno - to 30 кап. / mines (1,5 ml/min.); the maximum daily dose for adults - 250 ml.

At adults with a normal metabolism the daily dose of the entered dextrose should not exceed 4-6 g/kg, i.e. about 250-450 g (at decrease in metabolic rate daily a dose reduce up to 200-300 g), at the same time the daily volume of the entered liquid - 30-40 ml/kg.

To children for parenteral food, along with fats and amino acids, in the first day enter 6 g of Dextrosums/kg/days, in the subsequent - to 15 g/kg/days.

Rate of administering: at a normality of a metabolism the maximum rate of administering of a dextrose adult - 0,25-0,5 g/kg/h (at decrease in metabolic rate rate of administering is reduced to 0,125-0,25 g/kg/h). At children rate of administering of a dextrose should not exceed 0,5 g/kg/h.

For fuller assimilation of the dextrose entered in high doses along with it appoint insulin at the rate of 1 PIECE of insulin to 4-5 g of a dextrose.

Sick diabetes the dextrose is entered under control of its content in blood and urine.

Features of use:

For fuller assimilation of the dextrose entered in high doses along with it appoint insulin at the rate of 1 unit of insulin to 4-5 g of a dextrose.

At a combination with other medicines it is necessary to control compatibility visually.

Side effects:

Disturbances of ionic balance, hyperglycemia, fever, hypervolemia, acute left ventricular failure.

In an injection site - development of an infection, thrombophlebitis.

Contraindications:

Hypersensitivity, hyperglycemia, diabetes mellitus, hyper lactacidemia, overhydratation, postoperative disturbances of utilization of glucose; the circulator disturbances menacing with wet brain and lungs; wet brain, fluid lungs, acute left ventricular failure, giperosmolyarny coma.

With care. Dekompensirovanny chronic heart failure, chronic renal failure (oligo-, anury), hyponatremia.

Storage conditions:

At a temperature of 5-30 °C, in the place, unavailable to children. Freezing of drug on condition of preservation of tightness of ampoules is not a contraindication to its use. A period of validity - 5 years. Not to use after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous administration, 40%. Packaging: on 5 ml in ampoules from glass.
On 10 ampoules together with a knife or a skayorifikator for opening of ampoules and the instruction on a medical primeyoneniye place in a box from a kartoyon. In case of use of ampoules with kolyyotsy a break or with a notch and a point of a break, the investment of a knife or a skarifiyokator for opening of ampoules does not preduyosmatrivatsya.