Glucose

General characteristics. Structure:

Active agent: Dextrosums monohydrate (glucose monohydrate, glucose (С*ФармДекс)) (in terms of a dextrose) - 50 g Excipients: sodium chloride — 0,26 g, 0,1 M of Acidum hydrochloricum solution — to pH 3,0-4,1, water for injections — to 1 l.

Pharmacological properties:

Pharmacodynamics. Participates in various processes of a metabolism in an organism, strengthens oxidation-reduction processes in an organism, improves anti-toxic function of a liver.
Injection of solutions of a dextrose partially fills water shortage. A dextrose, coming to fabrics, it is phosphorylated, turning into glyukozo-6-phosphate which actively joins in many links of a metabolism of an organism.
5% solution of a dextrose have disintoxication, metabolic effect, is a source of valuable digestible nutrient. At metabolism of a dextrose in fabrics a significant amount of the energy necessary for life activity of an organism is allocated.

Pharmacokinetics. It is acquired completely by an organism, by kidneys it is not removed (emergence in urine is a pathological sign).

Indications to use:

Hypoglycemia, insufficiency of carbohydrate food, toxicoinfection, in-toxication at liver diseases (hepatitis, dystrophy and a hepatatrophia, including a liver failure), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.
As component of various blood-substituting and antishock liquids; for preparation of solutions of the medicines (M) for intravenous administration (in/in).

Route of administration and doses:

Intravenously (into) kapelno, 5% solution is entered with the maximum speed up to 7 ml (the 150th cap) / mines (400 ml/h); the maximum daily dose for adults - 2 l. In/in struyno - 10-50 ml of 5% of solution. At adults with a normal metabolism the daily dose of the entered dextrose should not exceed 4-6 g/kg, i.e. about 250-450 g (at decrease in metabolic rate the daily dose is reduced to 200-300 g), at the same time the daily volume of the entered liquid - 30-40 ml/kg. To children for parenteral food along with fats and amino acids in the first day enter 6 g of Dextrosums/kg/days, in the subsequent - to 15 g/kg/days. When calculating a dose of a dextrose at introduction of 5 and 10% of solutions of a dextrose it is necessary to take the admissible volume of the entered liquid into account: for children with the body weight of 2-10 kg - 100-165 ml/kg/days, to children with the body weight of 10-40 kg - 45-100 ml/kg/days. Rate of administering: at a normality of a metabolism the maximum rate of administering of a dextrose adult - 0.25-0.5 g/kg/h (at decrease in metabolic rate rate of administering is reduced to 0.125-0.25 g/kg/h). At children rate of administering of a dextrose should not exceed 0.5 g/kg/h that makes for 5% of solution - about 10 ml/min. or 200 caps/min. (the 20th cap = 1 ml). For fuller assimilation of the dextrose entered in high doses along with it appoint insulin at the rate of 1 PIECE of insulin to 4-5 g of a dextrose. Sick diabetes the dextrose is entered under control of its content in blood and urine.

Features of use:

It is necessary to appoint with care a sick diabetes mellitus (for the dosage forms containing sugar).

Side effects:

Nausea, dacryagogue, dizziness.

Interaction with other medicines:

At a combination with other medicines it is necessary to control pharmaceutical compatibility visually.

Contraindications:

Hypersensitivity, hyperglycemia, hyper lactacidemia, overhydratation, postoperative disturbances of utilization of glucose; the circulator disturbances menacing with wet brain and lungs, wet brain, a fluid lungs, an acute left ventricular failure, a giperosmolyarny coma. 
Use at pregnancy Use at pregnancy and a lactation perhaps on doctor's orders.

Overdose:

Symptoms: hyperglycemia, glucosuria, disturbance of water and electrolytic balance.
Treatment: to stop administration of solution of glucose, to enter insulin; symptomatic therapy.

Storage conditions:

In the dry, protected from light place, at a temperature from 5 to 20 °C. To store in the places unavailable to children. Period of validity 3 years. Not to use after expiry date.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions, 5 mg/ml, 10 mg/ml.
On 100 ml in bottles or bottles glass with a capacity of 100 ml.
1 bottle together with the application instruction in a pack of cardboard or 10 bottles together with the application instruction in a box cardboard (packaging for hospitals).