Glyukosteril

General characteristics. Structure:

Active ingredient: 200 g of a dextrose anhydrous (in the form of 220 g of a dextrose of monohydrate).

Energy value 3360 kJ/l (800 kcal/l), theoretical osmolarity of 1110 ¼Äß¼/l.

Excipients: Acidum hydrochloricum of 25% - q.s. for correction pH, sodium hydroxide - q.s. for correction pH, water for injections.

Pharmacological properties:

Pharmacodynamics. Thanks to participation in various processes of a metabolism of Dextrosum has diverse effect on an organism: strengthens oxidation-reduction processes in an organism, improves anti-toxic function of a liver.

Injection of solutions of a dextrose partially fills water shortage. A dextrose, coming to fabrics, it is phosphorylated, turning into glyukozo-6-phosphate which actively joins in many links of a metabolism of an organism.

At metabolism of a dextrose in fabrics a significant amount of the energy necessary for life activity of an organism is allocated.

Hypertonic salt solutions (20%) increase the osmotic pressure of blood, improve a metabolism; increase contractility of a myocardium; improve anti-toxic function of a liver, expand vessels, increase a diuresis. Theoretical osmolarity of 20% - 1110 ¼Äß¼/l.

Pharmacokinetics. It is acquired completely by an organism, by kidneys it is not removed (emergence in urine you show a pathological sign).

Indications to use:

— hypoglycemia;

— insufficiency of carbohydrate food;

— toxicoinfections;

— intoxications at liver diseases (hepatitis, dystrophy and a hepatatrophia, a liver failure);

— hemorrhagic diathesis;

— dehydration (vomiting, diarrhea, postoperative period);

— intoxication;

— collapse;

— shock.

Is a component of various blood-substituting and antishock liquids; for preparation of solutions of medicines for in/in introductions.

Route of administration and doses:

Appoint - up to 30-40 thaws/min. with a speed of 1.5-2 ml/min.; the maximum daily dose for adults - 500 ml.

At adults with a normal metabolism the daily dose of the entered dextrose should not exceed 4-6 g/kg, i.e. about 250-450 g (at decrease in metabolic rate the daily dose is reduced to 200-300 g), at the same time the daily volume of the entered liquid - 30-40 ml/kg.

To children for parenteral food along with fats and amino acids in the first day enter 6 g of Dextrosums/kg/days, in the subsequent - to 15 g/kg/days.

Rate of administering: at a normality of a metabolism the maximum rate of administering of a dextrose adult - 0.25-0.5 g/kg/h (at decrease in metabolic rate, rate of administering is reduced to 0.125-0.25 g/kg/h).

At children rate of administering of a dextrose should not exceed 0.5 g/kg/h.

For fuller assimilation of the dextrose entered in high doses along with it appoint insulin at the rate of 1 PIECE of insulin to 4-5 g of a dextrose.

Sick diabetes mellitus the dextrose is entered under control of its content in blood and urine.

Features of use:

Use at renal failures. With care: chronic renal failure (oliguria or anury).

Use for children. To children for parenteral food along with fats and amino acids in the first day enter 6 g of Dextrosums/kg/days, in the subsequent - to 15 g/kg/days.

At children rate of administering of a dextrose should not exceed 0.5 g/kg/h.

Special instructions. For fuller and bystry assimilation of a dextrose it is possible to enter п / to 4-5 PIECES of insulin, at the rate of 1 PIECE of insulin on 4-5 g of a dextrose. At a combination with other drugs it is necessary to control visually compatibility (invisible chemical or therapeutic incompatibility is possible).

Side effects:

Hyperglycemia, hypervolemia, acute left ventricular failure.

In an injection site development of an infection, thrombophlebitis.

Interaction with other medicines:

So far it was not noted.

Contraindications:

— hyperglycemia;

— diabetes mellitus;

— hyper lactacidemia;

— overhydratation;

— postoperative disturbances of utilization of glucose;

— the circulator disturbances menacing with wet brain and lungs;

— wet brain;

— fluid lungs;

— acute left ventricular failure;

— giperosmolyarny coma;

— hypersensitivity.

With care: dekompensirovanny heart failure, chronic renal failure (oliguria or anury), hyponatremia.

Overdose:

Symptoms: hyperglycemia.

Treatment: symptomatic.

Storage conditions:

To store in the place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 5 years.

Issue conditions:

According to the recipe

Packaging:

250 ml - bottles glass (6) - boxes cardboard.
250 ml - bottles glass with the holder (6) - boxes cardboard.
250 ml - bottles glass (10) - boxes cardboard.
250 ml - bottles glass with the holder (10) - boxes cardboard.
500 ml - bottles glass (6) - boxes cardboard.
500 ml - bottles glass with the holder (6) - boxes cardboard.
500 ml - bottles glass (10) - boxes cardboard.
500 ml - bottles glass with the holder (10) - boxes cardboard.
1000 ml - bottles glass (6) - boxes cardboard.
1000 ml - bottles glass with the holder (6) - boxes cardboard.
1000 ml - bottles glass (10) - boxes cardboard.
1000 ml - bottles glass with the holder (10) - boxes cardboard.
250 ml - bottles plastic with a loop holder (10) - boxes cardboard.
250 ml - bottles plastic with a loop holder (20) - boxes cardboard.
500 ml - bottles plastic with a loop holder (10) - boxes cardboard.
500 ml - bottles plastic with a loop holder (20) - boxes cardboard.
1000 ml - bottles plastic with a loop holder (10) - boxes cardboard.
1000 ml - bottles plastic with a loop holder (20) - boxes cardboard.