Inosine Bufus

General characteristics. Structure:

Active ingredient: 20 mg of inosine (inosine).

Excipients: methenamin (hexamethylenetetramine), sodium hydroxide (1M solution of natron caustic), water for injections.

Pharmacological properties:

Pharmacodynamics. Inosine – derivative (nucleoside) of purine – the predecessor of adenosinetriphosphate (ATP). Treats group of the medicines stimulating metabolic processes. Has anti-hypoxemic and antiarrhytmic effect. Increases power balance of a myocardium, improves coronary circulation, prevents effects of intraoperative ischemia of kidneys. Is directly involved in exchange of glucose and promotes activation of exchange in the conditions of a hypoxia and in the absence of ATP.

Activates metabolism of the pyruvic acid necessary for ensuring normal process of tissue respiration and also promotes activation of a xanthinedehydrogenase. Stimulates synthesis of nucleotides, increases activity of some enzymes of a tricarbonic acid cycle. Getting into cells, has positive effect on processes of metabolism in a myocardium – increases force of reductions of heart and promotes fuller relaxation of a myocardium in a diastole therefore the stroke output increases. The mechanism of antiarrhytmic action is up to the end not clear.

Reduces aggregation of thrombocytes, activates an angenesis (especially a myocardium and a mucous membrane of digestive tract).

Pharmacokinetics. It is metabolized in a liver with formation of glucuronic acid and the subsequent its oxidation. In insignificant quantity it is allocated with urine.

Indications to use:

Complex treatment of the postponed myocardial infarction, coronary heart disease, the disturbances of a cordial rhythm caused by use of cardiac glycosides against the background of a myocardial dystrophy after the postponed infectious diseases. Liver diseases (hepatitises, cirrhosis, fatty dystrophy), urokoproporfiriya. The isolated kidney operations (as means of pharmacological protection at blood circulation switching off).

Route of administration and doses:

Drug is used intravenously struyno slowly or kapelno (40–60 drops 1 minute). Treatment begin with introduction 200 mg (10 ml of 2% of solution) once a day, then, at good tolerance, the dose is increased to 400 mg (20 ml of 2% of solution) by 1–2 times a day. Duration of treatment is 10–15 days.

Jet administration of drug is possible at acute disorders of a heart rhythm in a single dose of 200-400 mg (10–20 ml of 2% of solution).

For pharmacological protection of the kidneys subjected to ischemia, Inosine is entered intravenously struyno in a single dose of 1200 mg (60 ml of 2% of solution) in 5–15 minutes prior to crossclamping of a renal artery, and then by 800 more mg (40 ml of 2% of solution) immediately after blood circulation recovery.

At drop introduction to a vein of 2% solution of drug is dissolved in 5% solution of a dextrose (glucose) or isotonic solution of sodium of chloride (to 250 ml).

Side effects:

Allergic reactions: a skin itch, a dermahemia, a small tortoiseshell (drug should be cancelled).

Seldom: increase in concentration of uric acid in blood, an exacerbation of gout (at prolonged use).

Interaction with other medicines:

Now it is not revealed.

Contraindications:

Hypersensitivity to drug, gout, a hyperuricemia, pregnancy, the lactation period, age up to 18 years (efficiency and safety are not established).

With care to apply at a renal failure.

Storage conditions:

List B. In the place protected from light at a temperature from 15 to 25 °C. To store in the place, unavailable to children. A period of validity - 3 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous administration of 20 mg/ml. On 5 ml, 10 ml in ampoules of neutral glass or in ampoules polymeric of polyethylene of high pressure, or from polyethylene of low pressure, or from polyethylene for the medical purposes, or from polyethylene or polypropylene for infusion solutions and injection drugs.

On 10 ampoules of neutral glass with the application instruction place in a box from a cardboard with a corrugated insert from paper renal.

Put a knife in each box ampoule or the scarificator.

When packaging ampoules with notches, rings and points ampoule or scarificators do not put knives.

On 10 ampoules polymeric with the application instruction place in a pack from a cardboard.