Inosine

General characteristics. Structure:

Active ingredient: 20 mg of inosine (inosine).

Excipients: hexamethylenetetramine (methenamin), solution of natron caustic (sodium hydroxide), water for injections.

Drug kazyvat anti-hypoxemic and antiarrhytmic action. Increases power balance of a myocardium, improves coronary circulation, prevents effects of intraoperative ischemia of kidneys.

Pharmacological properties:

Pharmacodynamics. Inosine - derivative (nucleoside) of purine - the predecessor of adenosinetriphosphate (ATP). Treats group of the medicines stimulating metabolic processes. Has anti-hypoxemic and antiarrhytmic effect. Increases power balance of a myocardium, improves coronary circulation, prevents effects of intraoperative ischemia of kidneys. Is directly involved in exchange of glucose and promotes activation of exchange in the conditions of a hypoxia and in the absence of ATP.

Activates metabolism of pyruvic acid necessary for ensuring normal process of tissue respiration, and also promotes activation of a xanthinedehydrogenase. Stimulates synthesis of nucleotides, increases activity of some enzymes of a tricarbonic acid cycle. Getting into cells, has positive effect on processes of metabolism in a myocardium - increases force of reductions of heart and promotes fuller relaxation of a myocardium in a diastole therefore the stroke output increases. The mechanism of antiarrhytmic action is up to the end not clear. Reduces aggregation of thrombocytes, activates an angenesis (especially a myocardium and a mucous membrane of a GIT).

Pharmacokinetics. It is metabolized in a liver with formation of glucuronic acid and the subsequent its oxidation. In insignificant quantity it is allocated with urine.

Indications to use:

Complex treatment of the postponed myocardial infarction, coronary heart disease, the disturbances of a cordial rhythm caused by use of cardiac glycosides; myocardial dystrophies after the postponed infectious diseases. Liver diseases (hepatitises, cirrhosis, fatty dystrophy), urokoproporfiriya. Operations of a pas to the isolated kidney (as means of pharmacological protection at blood circulation switching off).

Route of administration and doses:

Drug is used intravenously struyno slowly or kapelno (40-60 drops 1 minute). Treatment begin with introduction 200 mg (10 ml of 2% of solution) once a day, then, at good tolerance, the dose is increased to 400 mg (20 ml of 2% of solution) by 1-2 times a day. Duration of treatment is 10-15 days.

Jet administration of drug is possible at acute disorders of a heart rhythm in a single dose of 200-400 mg (10-20 ml of 2% of solution). For pharmacological protection of the kidneys subjected to ischemia, inosine is entered intravenously struyno in a single dose of 1,2 g (60 ml of 2% of solution) in 5-15 minutes prior to crossclamping of a renal artery, and then by 0,8 more g (40 ml of 2% of solution) immediately after blood circulation recovery.

At drop introduction to a vein of 2% solution of drug is dissolved in 5% solution of a dextrose (glucose) or 0,9% chloride sodium solution (to 250 ml).

Side effects:

Allergic reactions: a skin itch, a dermahemia (drug should be cancelled). Seldom: increase in concentration of uric acid in blood, an exacerbation of gout (at prolonged use).

Contraindications:

Hypersensitivity to drug, gout, a hyperuricemia, pregnancy, the lactation period, age up to 18 years (efficiency and safety are not established). With care to apply at a renal failure.

Storage conditions:

In the dry, protected from light place at a temperature from 20-25 °C. In the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous administration of 20 mg/ml. 5 ml in ampoules of neutral glass. 5 ampoules in a blister strip packaging from a PVC film. 2 planimetric packagings place in a pack from a cardboard. 10 ampoules place in a pack from a cardboard with partitions or lattices, or a separator from a cardboard or paper bag. 10 ampoules place in a box from a cardboard. Put the application instruction and a knife in each pack or a box ampoule or the scarificator ampoule. When using ampoules with notches, rings of a break or points of a break the knife ampoule or the scarificator ampoule is not put.