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medicalmeds.eu Medicines Immunoexcitant. Galavit

Galavit

Препарат Галавит. ЗАО "ЦСМ Медикор" Россия



General characteristics. Structure:

Active agent: аминодигидрофталазиндион sodium dihydrate of 50 mg

Active agent: аминодигидрофталазиндион sodium dihydrate of 100 mg.




Pharmacological properties:

Immunomodulatory drug with antiinflammatory action.

The mechanism of action is connected with ability to influence functional and metabolic activity of macrophages. At inflammatory diseases reversibly (on 6-8 h) inhibits excess synthesis of a factor of a necrosis of tumors, interleykina-1 and other pro-inflammatory cytokines, active forms of oxygen the hyper elicited macrophages defining extent of inflammatory reactions, their recurrence, and also expressiveness of intoxication. Normalization of a functional condition of macrophages leads to recovery of the antigen presenting and regulating function of macrophages, decrease in level of an autoaggression.
Drug stimulates bactericidal activity of neutrocytes, strengthening phagocytosis and increasing nonspecific resistance of an organism to infectious diseases.
The main pharmacological effects are observed during 72 h.

Pharmacokinetics. It is brought out of an organism, generally by kidneys. At hypoglossal use of T1/2 makes 30 min.


Indications to use:

As an immunomodulator and anti-inflammatory drug in complex therapy of immunodeficiency at adults:
— the infectious intestinal diseases which are followed by intoxication and/or diarrhea;
peptic ulcer of a stomach and duodenum;
— viral hepatitis;
— the chronic recurrent diseases caused by a herpes virus;
— the diseases caused by the virus of papilloma of the person (VPP);
— infectious and inflammatory diseases of an urogenital path (urethritis of a Chlamidia and mecotic etiology, Chlamidia prostatitis, acute and chronic salpingo-oophoritis, chronic endometritis);
— pyoinflammatory diseases of bodies of a small pelvis (VZOMT);
— postoperative rehabilitation of patients with a hysteromyoma;
— complications of the postoperative period at patients of reproductive age;
— postoperative it is purulent - septic complications and their prevention (including at oncological patients);
— chronic recurrent furunculosis, erysipelatous inflammation;
— asthenic states, neurotic and somatoformny frustration, decrease in physical effeciency (including at athletes);
— mental, behavioural and post-abstinent disorders at alcohol and drug addiction;
— inflammatory diseases of a mucous membrane of an oral cavity and throat, disease of a parodont.

As immunomodulatory and protivospalitelny means in complex therapy of immunodeficiency at children 6 years are aged more senior:
— purulent surgical diseases (including burn defeats, a recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with an omentitis, peritonitis, purulent pleurisy);
— frequent recurrent respiratory diseases and ENT organs of a bacterial and virus etiology (including frequent SARS, bronchitis, pneumonia, adenoid disease, chronic otitis, chronic adenoiditis).


Route of administration and doses:

In oil: before introduction contents of a bottle are parted in 2 ml of water for injections or 0,9% of solution of sodium of chloride. The dose and duration of use depend on character, weight and duration of a disease. A dosage for adults and teenagers since 12 years — 100 mg, for children of 6-12 years — 50 mg.

At a peptic ulcer of a stomach and duodenum in the acute period: 2 days on 200 mg once a day, then on 100 mg with an interval of 72 h. A course — 20–25 injections. In the chronic period — 5 days on 100 mg once a day, then on 100 mg in 72 h. A course — 20 injections.

At a viral hepatitis: an initial dose — 200 mg once, then on 100 mg 2 times a day before stopping of symptoms of intoxication and an inflammation. The subsequent continuation of a course — on 100 mg with an interval of 72 h. A course — 20–25 injections.

At the chronic recurrent diseases caused by a herpes virus — on 100 mg daily 5 injections, then on 100 mg every other day 15 injections.

At the diseases caused by a papilloma virus — 5 days on 100 mg once a day, then on 100 mg every other day. A course — 20 injections.

At urogenital diseases — an urethritis of a Chlamidia and mecotic etiology, Chlamidia prostatitis: 1 day on 100 mg twice, then on 100 mg every other day. A course — 10–15 injections (depending on weight of pathological process).

At a salpingo-oophoritis, an endometritis: during the acute period — 2 days on 200 mg once a day, then on 100 mg with an interval of 72 h. In the chronic period — 5 days on 100 mg once a day, then on 100 mg in each 72 h. A course — 20 injections.

At acute and chronic purulent diseases of bodies of a small pelvis: in the acute period — 1 day of 200 mg once, 3 days on 100 mg daily, then on 100 mg every other day 5 injections. A course — 10 injections. In the chronic period — 5 days on 100 mg once a day, then 100 mg in each 72 h. A course — 20 injections.

For postoperative rehabilitation of patients with a hysteromyoma and at complications of the postoperative period at women of reproductive age: 5 days on 100 mg once a day, then on 100 mg every other day. A course — 20 injections.

For prevention and treatment of surgical complications in to - and the postoperative period (including at oncological patients) appoint on 100 mg 5 injections before operation, 5 injections after operation on 100 mg every other day and 5 injections on 100 mg with an interval of 72 h once a day. At a severe disease an initial dose — 200 mg once or 2 times a day on 100 mg. A course — 20 injections.

At a chronic recurrent furunculosis, an ugly face: 5 days on 100 mg once a day, then on 100 mg every other day. A course — 20 injections.

At asthenic states, neurotic and somatoformny frustration, at mental, behavioural and post-abstinent disorders, at patients with alcohol and drug addiction: 5 days on 100 mg daily, then on 100 mg in 72 h. A course — 15–20 injections.

For increase in physical effeciency: on 100 mg every other day 5 injections, then on 100 mg in 72 h, a course — to 20 injections.

At inflammatory diseases of a mucous membrane of an oral cavity and throat, diseases of a parodont: an initial dose — 100 mg daily 5 injections, then on 100 mg with an interval of 72 h. A course — 20 injections.

In oil at adults and teenagers since 12 years in monotherapy

At the acute and chronic infectious and inflammatory gastrointestinal diseases which are followed by intoxication and/or diarrhea — 200 mg once, then on 100 mg 2 times a day before stopping of symptoms of intoxication. The subsequent continuation of a course on 100 mg with an interval of 72 h is possible. A course — 20–25 injections.

At persistent urogenital infections, including when holding immunorehabilitation actions during the interrecurrent period for the purpose of maintenance of clinical remission: on 100 mg every other day a course in 10 injections.

In oil at children 6 years are more senior

At purulent surgical diseases (burn defeats, a recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with an omentitis, peritonitis, purulent pleurisy): children are from 6 to 11 years old — on 1 injection of 50 mg daily — 5 days, then on 1 injection of 50 mg every other day within 10–15 days. A course — 10–15 injections; to children at the age of 12–18 years — treatment is carried out according to the same scheme in the form of injections in oil on 100 mg. When bandagings external use of a galavit in the form of bandages with the sterile napkins moistened with 1% solution of a galavit in water for injections is desirable (in bandages with the talker or water-soluble salve dressings).

At frequent recurrent respiratory diseases and ENT organs of a bacterial and virus etiology (frequent SARS, bronchitis, pneumonia, adenoid disease, chronic otitis, chronic adenoiditis): children are from 6 to 11 years old — on 1 injection of 50 mg daily within 5 days, then on 50 mg once a day every other day within 10–15 days. A course — 10–15 injections. To children at the age of 12–18 years — treatment according to the same scheme in the form of injections in oil on 100 mg.


Features of use:

Special instructions on use of drug are absent.


Side effects:

Perhaps: allergic reactions.


Interaction with other medicines:

It is not established clinically significant interaction of the drug Galavit® with other medicines.


Contraindications:

— pregnancy;
— lactation;
— individual intolerance.

Use of the drug GALAVIT® at pregnancy and feeding by a breast
Drug is contraindicated at pregnancy and in the period of a lactation.


Overdose:

So far about cases of overdose of the drug Galavit® it was not reported.


Storage conditions:

Drug should be stored in protected from light, the place, unavailable to children, at a temperature not above 25 °C.


Issue conditions:

According to the recipe


Packaging:

Powder for пригот. solution for introduction of 100 mg in oil: фл. 3 or 5 pieces.

Powder for пригот. solution for introduction of 50 mg in oil: фл. 3 or 5 pieces.



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