Gepatrombin

General characteristics. Structure:

Active agent: heparin sodium 120 ME *; Prednisolonum acetate of 1.675 mg; лауромакрогол 600 30 mg

Excipients: triglycerides srednetsepochny - 1.08 mg, silicon dioxide colloid - 11.4 mg, fat firm (Novata B) - 1801.2 mg, glyceryl tristearate - 27.5 mg.

Pharmacological properties:

The combined drug with antitrombotichesky, antiinflammatory and venosklerozirushchy action for topical administration in a proctology.
Heparin - anticoagulant of direct action. At external use renders local antitrombotichesky, antiexudative and moderate antiinflammatory action; promotes regeneration of connecting fabric; prevents blood coagulation in hemorrhoidal nodes.
Prednisolonum - GKS, has antiinflammatory, antiexudative and antiallergic effect, reduces an itch, burning sensation, pain in anorectal area.
Lauromakrogol 400 (полидоканол) has mestnoanesteziruyushchy effect and provides a sklerozirovaniye of hemorrhoidal nodes.

Pharmacokinetics. Heparin. Absorption and metabolism.
After absorption it biotransformirutsya in a liver (partially by enzyme a hepatic haparinase) and in reticuloendothelial system.

Distribution and removal. Linkng with proteins of plasma makes 95%.
Vd increases with increase in a dose. It is removed by kidneys. T1/2 - 60-90 min.

Prednisolonum. Absorption and metabolism. Prednisolonum after absorption biotransformirutsya in a liver.

Removal. About 1% is removed with urine in not changed look. Biological T1/2 makes 18-36 h, and T1/2 of plasma - 115-212 min.

Indications to use:

— outside and internal hemorrhoids;
— thrombophlebitis of veins of an anus;
— fistulas, eczema and an itch in the field of an anus;
— anus cracks.

Route of administration and doses:

Rektalno suppositories enter 1-2 times / сут.после defecations.

For administration of ointment in a rectum the tip which is screwing on on a tube which is entered into a rectum is used and easy pressing a tube squeeze out a small amount of ointment.

Features of use:

When drawing a large amount of drug on the injured skin or mucous membranes delay of processes of regeneration is noted.

Side effects:

Local reactions: allergic reactions, dermahemia.
At prolonged use and/or when drawing on big surfaces system side effects are possible.

Interaction with other medicines:

Data on medicinal interaction of drug Gepatrombin are not provided.

Contraindications:

— bacterial, virus, fungal infections of skin;
— tuberculosis;
— syphilis;
— skin tumors;
— reactions to vaccination;
— predisposition to bleedings;
— I trimester of pregnancy;
— hypersensitivity to drug components.

Use of drug GEPATROMBIN G at pregnancy and feeding by a breast
Drug is contraindicated to use in the I trimester of pregnancy.

Overdose:

Data on drug overdose Gepatrombin are not provided.

Storage conditions:

Drug should be stored in the place, unavailable to children, at a temperature from 15 °C to 25 °C.

Issue conditions:

Without recipe

Packaging:

Suppositories рект.: 10 pieces.