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medicalmeds.eu Medicines Cyanocobalamine and its analogs. Tsikomin-Altfarm

Tsikomin-Altfarm

Препарат Цикомин-Альтфарм. ООО "Альтфарм" Россия


Producer: LLC Altfarm Russia

Code of automatic telephone exchange: B03BA01

Release form: Firm dosage forms. Suppositories rectal.

Indications to use: B12-scarce anemia. Polyneuritis. Radiculitis. Neuralgia. Hypotrophy. Funicular myelosis.


General characteristics. Structure:

Active agent: cyanocobalamine – 0,5 mg; 

Excipients: глицерол (glycerin), lanolin anhydrous, fatty acids glycerides (витепсол H 15).

Description: 

Suppositories of pink color of a torpedo-shaped form.




Pharmacological properties:

Cyanocobalamine (B12 vitamin) has metabolic, hemopoietic effect. Participates in synthesis of labile methyl groups and in formation of sincaline, methionine, creatine, nucleic acids; promotes accumulation in erythrocytes of the connections containing sulphhydryl groups. In high doses causes increase in thromboplastic activity and activity of a prothrombin. Activates exchange of carbohydrates and lipids.


Indications to use:

Treatment and prevention of deficit of B12 vitamin. Complex therapy of a polyneuritis, radiculitis, neuralgia (including epileptiform neuralgias), hypotrophies, a funicular myelosis, at an injury of peripheral nerves, a side amyotrophic sclerosis.


Route of administration and doses:

The adult for elimination of deficit of B12 vitamin – on 1 mg (2 suppositories) daily within 1-2 weeks, for prevention of deficit of B12 vitamin – on 1 mg (2 suppositories) once a month. At diseases of a peripheral nervous system – on 500 mkg (1 suppository) every other day within 2 weeks.


Features of use:

Deficit of B12 vitamin has to be confirmed. During treatment it is necessary to control blood indicators: for 5-8 day of treatment the maintenance of reticulocytes, concentration of iron is defined. The quantity of erythrocytes, Hb and a color indicator need to be controlled within 1 month 1-2 weekly. And further – 2-4 times a month. Remission is reached at increase in quantity of erythrocytes to 4-4,5 million / мкл, at achievement of the normal sizes of erythrocytes, disappearance anizo-and a poikilocytosis, normalization of maintenance of reticulocytes after reticulocytic crisis. After achievement of hematologic remission control of peripheral blood is carried out at least 1 time in 4-6 months.


Side effects:

Allergic reactions to drug components, a cardialgia, tachycardia, diarrhea, a headache, dizziness, a hyperphrenia. At use in high doses – hypercoagulation, disturbance of purine exchange. Interaction with other medicines: It is impossible to combine with the drugs increasing coagulability of blood. Chloramphenicol reduces the hemopoietic answer at simultaneous use with cyanocobalamine. Thiamin increases risk of development of allergic reactions.



Contraindications:

The increased individual sensitivity to drug components, a thromboembolism, an erythremia, a hyperglobulia, pregnancy, the lactation period.

With care: drug is appointed to patients with stenocardia; the high-quality and malignant new growths which are followed by megaloblastny anemia and deficit of B12 vitamin at tendency to formation of blood clots.

Use of drug during pregnancy and breastfeeding:

Drug is not recommended to be accepted during pregnancy and breastfeeding.



Storage conditions:

To store in the dry place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity: 2 years. Not to use after the period of validity specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Suppositories rectal 0,5 mg. On 5 suppositories in a blister strip packaging. 2 blister strip packagings together with the application instruction in a pack cardboard.



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