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medicalmeds.eu Medicines Antiseptic agents and antimicrobic drugs Clotrimazolum

Clotrimazolum

Препарат Клотримазол. ООО «Фармлэнд» Республика Беларусь


Producer: LLC Pharmlend Republic of Belarus

Code of automatic telephone exchange: G01AF02

Release form: Firm dosage forms. Tablets are vaginal.

Indications to use: Trichomoniasis. Sanitation of patrimonial ways. Candidiasis of a vagina (Milkwoman). Vulvovaginitis.


General characteristics. Structure:

Active ingredient: 500 mg of Clotrimazolum.

Excipients: starch corn, cellulose microcrystallic, sodium methylhydroxybenzoate, sodium пропилгидроксибензоат, povidone, talc, magnesium stearate, colloid silicon dioxide, sodium glikolit starch.

Antifungal broad-spectrum agent.




Pharmacological properties:

Pharmacodynamics. Clotrimazolum is derivative an imidazole. The effect of drug is connected with disturbance of synthesis of ergosterol, is a part of a cellular membrane of mushrooms that causes change of its structure and properties and leads to a lysis of a cell.

Dermatophytes, barmy mushrooms (the sorts Candida, Torulopsis glabrata, the sorts Rhodotorula), mold mushrooms, and also the Pityriasis versicolor activator (multi-colored depriving) and the erythrasma activator are sensitive to Clotrimazolum.

Besides, has antimicrobic effect concerning gram-positive (staphylococcus and streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), and also concerning Trichomonas vaginalis, Malassezia furfur, Corynebacterium minutissimum.

Pharmacokinetics. At external use Clotrimazolum is practically not absorbed in a system blood stream through integuments, in small degree is absorbed from mucous membranes.


Indications to use:

- the genital infections caused by mushrooms of the sort Candida and/or Trichomonas vaginalis (a candidosis vulvovaginitis, trichomoniasis);
- the genital superinfections caused by the bacteria sensitive to Clotrimazolum;
- sanitation of patrimonial ways before childbirth.


Route of administration and doses:

In the absence of other appointments single use of a vaginal tablet is recommended in the evening. To moisten a vaginal tablet with boiled chilled water and to enter as it is possible more deeply in a vagina.

If external symptoms of a disease (allocations, an itch) not completely disappeared after performing treatment, after consultation with the attending physician it is possible to continue drug use.


Features of use:

Prevention of spread of an urogenital infection requires simultaneous treatment of sexual partners. At trichomoniasis for more successful treatment together with Clotrimazolum it is necessary to appoint other medicines possessing systemic action.

Vaginal tablets are not recommended to be applied during periods.

In case of an unforeseen route of administration of drug the following symptoms - anorexia, nausea, vomiting, a gastralgia, an abnormal liver function, seldom drowsiness, hallucinations, a pollakiuria, skin allergic reactions are (orally) possible. In a verse situations it is necessary to accept absorbent carbon and to see a doctor.

Pregnancy and feeding by a breast. In security measures it is not recommended to use drug in the I trimester of pregnancy. Use of Clotrimazolum during pregnancy is possible only after consultation with the attending physician and without use of the applicator.


Side effects:

Local reactions - reddening mucous, a burning sensation and prickings are in rare instances noted.

At development of any by-effects which are not described above it is necessary to see the attending physician.


Interaction with other medicines:

At vaginal introduction Clotrimazolum reduces activity of Amphotericinum In and other half-yen antibiotics. At simultaneous use with nystatin activity of Clotrimazolum can decrease.


Contraindications:

Drug cannot be used with hypersensitivity to Clotrimazolum or to other components of drug.

18 years are aged younger, and also at primary disease use of drug is possible only after consultation with the attending physician as inflammatory processes can be caused by various reasons.


Overdose:

In case of an unforeseen route of administration of drug the following symptoms - anorexia, nausea, vomiting, a gastralgia, an abnormal liver function, seldom drowsiness, hallucinations, a frequent urination, skin allergic reactions are (orally) possible. In these situations it is necessary to accept absorbent carbon and to see a doctor.


Storage conditions:

To store in the dry, protected from light place at a temperature not above +25 °C. Period of validity 3 years. It is not necessary to use medicine after the period of validity specified on packaging!


Issue conditions:

According to the recipe


Packaging:

1 tablet in bank of polymeric. 1 bank in a pack.



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