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НУРОФЕН® (Tablets)

Препарат НУРОФЕН® (Таблетки). Reckitt Benckiser healthcare international Ltd. Великобритания


Producer: Reckitt Benckiser healthcare international Ltd. Great Britain

Code of automatic telephone exchange: M01AE01

Release form: Firm dosage forms. Tablets.

Indications to use: Neuralgia. Dysmenorrhea. Migraine. Dentagra. Headache. Rheumatic diseases. Hyper thermal syndrome (Fever). Catarrhal diseases. Flu.


General characteristics. Structure:

Active ingredient: an ibuprofen – 200 mg;
other components: sodium of a kroskarmelyoz, sodium lauryl sulfate, sodium citrate, stearic acid, colloid anhydrite of silicon, sodium of a karmelloz, talc, acacia, sucrose, titanium двооксид, макрагол 6000.




Pharmacological properties:

The nurofen shows analgeziruyushchy, febrifugal and antiinflammatory actions. The mechanism of action consists in suppression of synthesis of prostaglandins – pain mediators, an inflammation and temperature reaction.

Pharmacokinetics. After reception the ibuprofen is quickly absorbed from a digestive tract. The maximum concentration active substances in a blood plasma is defined in 1 - 2 hour. after reception, in synovial fluid - in 3 hours after reception. The ibuprofen is metabolized in a liver, removed by kidneys in an invariable look and in the form of metabolites. An elimination half-life – nearly 2 hours.


Indications to use:

The nurofen is applied at head, tooth pains, migraine, a dysmenorrhea, neuralgia, dorsodynias, joints, muscles, rheumatic pains, and also at feverish conditions and symptoms of cold and flu.


Route of administration and doses:

Recommended to adults and children by age 12 years are more senior. About 1 – 2 tablets are applied each 4 - 6 hour. The recommended initial dose makes 2 tablets. Tablets need to be washed down with water. Not to use more than 6 tablets during the 24th hour.


Features of use:

Appoint drug after consultation with the doctor at:
renal, heart or liver failure;
bronchial asthma or allergic diseases.
It is necessary to consult with the doctor to patients of advanced age, women during pregnancy and during feeding by a breast.

If symptoms of a disease remain, followed by high temperature, a headache or other phenomena, it is necessary to see a doctor.

It is not possible to exceed the specified dose.


Side effects:

At most of patients the drug Nurofen does not make side effect. However, there can sometimes be undesirable side effects which are shown in the form of discomfort from a digestive tract, in aggravated a peptic ulcer of a stomach, an abnormal liver function and kidneys, a headache, dizziness, short-term disorder of hearing; in isolated cases the skin rash and thrombocytopenia are observed.


Interaction with other medicines:

The concomitant use of tablets of the NUROFEN with acetylsalicylic acid (ASK) and other NPVP is not recommended. At co-administration the ibuprofen reduces antiinflammatory and antiagregantny effect of acetylsalicylic acid (ASK) (increase in frequency of development of acute coronary insufficiency in the patients receiving small doses of acetylsalicylic acid (ASK) as antiagregantny means after the beginning of reception of an ibuprofen is possible). At appointment with anticoagulating and thrombolytic medicines (alteplazy, Streptokinasa, an urokinase) the risk of development of bleedings at the same time increases. Tsefamandol, цефаперазон, цефотетан, valproic acid, пликамицин, increase purity of development of a prothrombinopenia. Cyclosporine and drugs of gold strengthen influence of an ibuprofen on synthesis of prostaglandins in kidneys that is shown by increase in nephrotoxicity. The ibuprofen increases plasma concentration of cyclosporine and probability of development of its hepatotoxic effects. The medicines blocking canalicular secretion reduce removal and increase plasma concentration of an ibuprofen. Inductors of a microsomal oxidation (Phenytoinum, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase products of hydroxylated active metabolites, increasing risk of development of heavy hepatotoxic reactions. Inhibitors of a microsomal oxidation – reduce risk of a hepatotoxic action. Reduces hypotensive activity of vazodilatator, natriuretic at furosemide and Hydrochlorthiazidum. Reduces efficiency of uricosuric drugs, strengthens effect of indirect anticoagulants, antiagregant, fibrinolitik. Strengthens side effects of mineralokortikosteroid, glucocorticosteroids, estrogen, ethanol. Strengthens effect of peroral hypoglycemic medicines, derivative sulphonylurea and insulin. Antacids and Colestyraminum reduce absorption. Increases concentration in blood of digoxin, drugs of lithium, a methotrexate. Caffeine strengthens analgeziruyushchy effect.


Contraindications:

- digestive tract erosive cankers in an aggravation phase, including a peptic ulcer of a stomach and a 12-perstny gut in an aggravation stage, ulcer colitis, a round ulcer, a disease Krone;
- heart failure;
- heavy course of arterial hypertension;
- hypersensitivity to an ibuprofen or to drug components;
- "aspirinovy" bronchial asthma, a small tortoiseshell, rhinitis, polyps mucous a nose, provoked by reception of acetylsalicylic acid (salicylates) or other NPVP;
- diseases of an optic nerve; disturbance of color sight, amblyopia, scotoma;
- deficit glyukozo-6-fosfatdegidrogenazy, hemophilia, conditions of hypocoagulation, gemmoragichesky diathesis;
- pregnancy III trimester, lactation period;
- the expressed abnormal liver functions and/or kidneys;
- decrease in hearing, pathology of a vestibular mechanism;
- children up to 6 years.
With care - at administration of drug at patients with a peptic ulcer of a stomach and a 12-perstny gut in the anamnesis, at gastritises, enterita, colitis, at anamnestic data on bleedings from digestive tract; in the presence of associated diseases of a liver and/or kidneys; at cirrhosis with portal hypertensia, a nephrotic syndrome, chronic heart failure; arterial hypertension; at diseases of blood of not clear etiology (a leukopenia and anemia); at bronchial asthma, at a hyperbilirubinemia; pregnancy (I, II trimesters); children's age up to 12 years.


Overdose:

Symptoms of overdose can be shown in the form of nausea, vomiting, dizziness, is rare - losses of consciousness.


Storage conditions:

To store in the place, unavailable to children, at a temperature not above 25 °C. Period of validity 3 years. Not to use after the termination of the period of validity specified on its packaging.


Issue conditions:

Without recipe


Packaging:

On 6 or 12 tablets in the blister (PVC/PVDH/aluminium).
One blister (on 6 or 12 tablets), two blisters (on 6 or 12 tablets), or 8 blisters (on 12 tablets) place 3 blisters (on 12 tablets) in a cardboard pack or a plastic container together with the application instruction.



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