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medicalmeds.eu Medicines Local means for treatment of an acne. Duak

Duak

Препарат Дуак. Stiefel Laboratories Ltd (Стифел Лабораториз Лтд.) Ирландия


Producer: Stiefel Laboratories Ltd (Stifel Laboratoriz Ltd.) Ireland

Code of automatic telephone exchange: D10A F

Release form: Soft dosage forms. Gel.

Indications to use: Acne.


General characteristics. Structure:

Active ingredients: 1 g of gel contains benzoyl of peroxide anhydrous (in the form of benzoyl of peroxide water) 50 mg of clindamycin (in the form of phosphate clindamycin) 10 mg;

Excipients: carbomer, диметикон, sodium laurylsulphosuccinate, Trilonum of B, glycerin, silicon dioxide colloid water, half-oxameasures, sodium hydroxide, the water purified.

Main physical and chemical properties: homogeneous gel of white or slightly yellowish color.




Pharmacological properties:

Pharmacodynamics. Clindamycin is a linkozamidny antibiotic with bacteriostatic action against gram-positive aerobic microorganisms and a wide range of anaerobic bacteria. Linkozamida, such as clindamycin, communicate with 23S in subunit of a bacterial ribosome and suppress early stages of synthesis of protein. Effect of clindamycin is preferential bacteriostatic though high concentration can have slow bactericidal effect against sensitive strains. Though clindamycin phosphate is inactive in vitro, bystry in vivo hydrolysis turns this connection on antibacterial active clindamycin. It is noted activity of clindamycin clinically at treatment of comedones at the patients having an acne at the levels, sufficient to be active against the majority of strains of Propionibacteium acnes. In vivo clindamycin inhibits all tested cultures of Propionibacteium acnes (MIC of 0,4 mkg/ml). After clindamycin use the percent of free fatty acids on the surface of skin decreased approximately from 14% to 1%. Benzoyl peroxide has soft keratolytic effect against comedones at all stages of their development. It is the oxidizing substances with bactericidal activity against Propionibacteium acnes, an organism that brings vulgar eels. Besides, it sebostatiky, counteracts an excessive producing skin fat that is associated with an acne. Addition of benzoyl of peroxide reduces the potential of emergence of organisms, resistant to clindamycin.

Pharmacokinetics. Transdermal absorption of clindamycin minimum. Peroxide benzoyl presence as a part of medicine did not influence chrezkozhny absorption of clindamycin. Researches on radio markings showed that peroxide benzoyl absorption through skin can happen only after its transformation on the benzoic acid. The benzoic acid is preferential conjugated with formation of hippuric acid which is removed by kidneys.


Indications to use:

Topical treatment of an acne (acne vulgaris).


Route of administration and doses:

Only for external use.

Adults and children are more senior than 12 years.

Duak is applied once a day in the evening on affected areas after careful cleaning and washing of skin with water. To put carefully, a thin layer before full absorption. Treatment Duak should not exceed 12 weeks of continuous use.


Features of use:

Treatment Duak should be carried out with care at patients with regional enteritis or ulcer colitis in the anamnesis, or colitis which is associated with antibiotics in the anamnesis. This medicine should be applied also with care at the patients having atopic dermatitis who can have a further xeroderma. When developing long or considerable diarrhea or if the patient suffers from spasms in a stomach, treatment Duak should be stopped immediately as these symptoms can indicate colitis which is associated with antibiotics. It is necessary to carry out the corresponding diagnostic methods, such as definition of Clostridium difficile and toxins, and also, if necessary, a kolonoskopiya, and also to consider options of treatment of colitis. In certain cases 4-6 weeks of treatment can be required before to reach full therapeutic effect. It is necessary to avoid contact with a mouth, eyes, mucous membranes and eczematic sites of skin. It is necessary to apply gel on sensitive sites of skin with care. In case of accidental contact with eyes to wash out their large number waters. The product can decolour hair or color fabrics. It is not recommended to be during treatment in the sun and under other ultra-violet radiation.

Ability to influence speed of response at control of motor transport or other mechanisms. It is not defined.

Use during pregnancy or feeding by a breast. Safety of use of Duak for women during pregnancy is not established therefore during this period appoint only when the estimated advantage for mother exceeds potential risk for a fruit. Oral and parenteral administration of clindamycin as it was reported, led to emergence of clindamycin in breast milk. Therefore Duak it is impossible to apply during feeding by a breast. Children. It is not shown for use for children up to 12 years.


Side effects:

Erythema, skin peeling, dryness and itch in a drug site of application, an exacerbation of a disease. In rare instances there can be paresthesias and contact dermatitis. At prolonged use Duak can develop resistance of microorganisms to clindamycin that can give superinfections. Allergic reactions.


Interaction with other medicines:

At use of the local antibiotics, medical, usual or abrasive soap and cosmetics having pidsushuvalny effect, and also means with high concentration of alcohol and/or the knitting agents the cumulative irritating effect can be observed. Extra care should be observed at use of the drugs containing the substances promoting a skin peeling (бензоилпероксид). It is necessary to avoid simultaneous use Duak and local medicines for treatment of the acne containing derivatives of vitamin of A.Pri monotherapy use by antibiotics there can be a cross resistance with other antibiotics, such as lincomycin and erythromycin. There is potential synergism between clindamycin and gentamycin.


Contraindications:

Hypersensitivity and lincomycin. Age up to 12 years. Feeding period breast.


Overdose:

It is not described.


Storage conditions:

Period of validity - 1,5 years. A period of validity after opening of a tuba - 2 months. To store in the place, unavailable to children. To store in the refrigerator (2 º With - 8 º C). Not to freeze.


Issue conditions:

According to the recipe


Packaging:

On 15 g of gel in a tuba, on 1 tuba in a cardboard box.



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