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medicalmeds.eu Medicines Cure for topical administration for joint and muscular pain. Dimeksid-FT

Dimeksid-FT

Препарат Димексид-ФТ. ООО «Фармтехнология» Республика Беларусь



General characteristics. Structure:

Active ingredient: 100% dimethyl sulfoxide.

Anti-inflammatory, soothing, antimicrobic drug.




Pharmacological properties:

Pharmacodynamics. The dimethyl sulfoxide well gets through biological membranes, including through skin, mucous, a cover of microbic cells (increases their sensitivity to antibiotics), promoting penetration through skin and mucous membranes of medicines. Shows the anesthetizing activity expressed local at pain syndromes of various etiology, has antiinflammatory, antimicrobic and fibrinolitic effect, changes sensitivity of microflora, resistant to antibiotics. Performs also transport function, providing deep penetration of other medicines through skin and mucous.

Pharmacokinetics. When drawing on skin and mucous membranes quickly and almost it is completely soaked up. The dimethyl sulfoxide is found in blood serum in 5 min. after application on skin, the maximum concentration is reached in 4-6 h and remains almost invariable for 1,5-3 days. Well gets into cells of fabrics of all bodies, except for hair, nails and an adamantine substance of tooth. It is metabolized by oxidation in метилсульфонилметан, with the subsequent recovery to methyl thiomethane. Metabolites of a dimethyl sulfoxide are removed with urine and a stake, and also can be removed through skin and lungs that is followed by a specific garlick smell. Accumulation of a dimethyl sulfoxide and its metabolites in an organism at prolonged use of medicine does not happen.


Indications to use:

Apply to removal of a pain syndrome at complex therapy of inflammatory diseases of a musculoskeletal system (a pseudorheumatism, a disease of Bekhterev, the deforming osteoarthrosis, an arthropathy, radiculitis), to treatment of bruises, injury of ligaments, inflammatory hypostases, traumatic infiltrates, purulent wounds, burns, abscesses, at therapy of a knotty erythema, eczema, an erysipelatous inflammation, trophic ulcers, thrombophlebitis, acne, a pyoderma, streptoderma, furunculosis, folliculites, a scleroderma, in skin and plastic surgery – to engraftment replaced skin auto-and gomotransplantat, and also to conservation of skin gomotransplantat.


Route of administration and doses:

Medicine is produced in the form of a concentrate from which before use prepare solution of necessary concentration. Apply preferential in the form of aqueous solutions (30 - 50%) to tampons and compresses. The compress should be imposed on affected areas, taking adjacent healthy integuments.

At treatment of an erysipelatous inflammation and trophic ulcers liquid is applied in the form of 30-50% of aqueous solution by 2-3 times a day.

At eczema, diffusion streptodermas compresses from 40-90% are recommended by Dimexidum solution.

At pustulous diseases of skin apply 40% solution.

For a local anesthesia recommend 25-50% medicine solution for compresses on 2-3 times a day.

At treatment of deep burns apply bandages from 20-30% solution.

In need of change of a route of administration recommendations are made by the doctor.

At hypersensitivity of skin and mucous membranes, and also at use apply 10% - 20% to face skin medicine solutions.

At children apply 9-18 years aqueous solutions of Dimexidum for which receiving drug is dissolved with water in ratios 1:4 and 1:3 respectively apply 20-30%, at children of 6-9 years apply Dimexidum only according to the recommendation of the doctor, at children up to 6 years do not apply Dimexidum.

In solution of necessary concentration moisten gauze napkins and apply an occlusive bandage from a polyethylene film and cotton or linen fabric. Duration of a course of treatment – 10-15 days.

In skin and plastic surgery use bandages from 10-20-30% aqueous solution on replaced skin auto-and gomotransplantata directly after operations and in the next days of the postoperative period before permanent engraftment of a transplant.

As the preserving environment for storage of skin gomotransplantat apply 5% dimethyl sulfoxide solution in Ringer's solution.

Preparation of aqueous solution of Dimexidum:

Maintenance of DimexidumQuantity of parts of DimexidumQuantity of parts of water
10% 1 9
20% 1 4
25% 1 3
30% 3 7
40% 2 3
50% 1 1
90% 9 1

Features of use:

Not to apply medicine on the injured skin and skin with displays of an allergy. Not to apply on face skin. It is necessary to avoid hit of medicine on a mucous membrane of an eye. At accidental hit it is necessary to wash out immediately water.

With care appoint to patients with burdened allergoanemnezy, and also to the persons having coronary heart disease.

Considering a possibility of individual intolerance of medicine, it is recommended to carry out medicinal test on portability. For this purpose medicine with a thin layer is applied on skin of an elbow bend. Emergence of sharp reddening and an itch testify to hypersensitivity to Dimexidum. This patient should not appoint dimeksidsoderzhashchy medicines. At emergence of allergic reactions to Dimexidum in the course of treatment, drug is cancelled.

At storage at a temperature of 18 °C and below crystallization of a dimethyl sulfoxide which does not influence quality of medicine is possible. For fusion of crystals it is necessary to warm a bottle with medicine in capacity with water (water temperature – about 40 °C).

Use at pregnancy and feeding by a breast. Use of medicine is contraindicated at pregnancy and a lactation. For the period of treatment by medicine breastfeeding needs to be stopped.

Children. Not to use at children 6 years are younger.


Side effects:

At cutaneous application of Dimexidum local reaction in the form of easy burning is possible, sometimes at a part of patients emergence of allergic reactions, pruritic dermatitis, an erythema, feeling of a xeroderma, burning, strengthening of a xanthopathy, sleeplessness, a garlick smell of expired air is possible. In isolated cases the bronchospasm is possible. Some patients badly perceive a medicine smell that can be followed by nausea, desires on vomiting.


Interaction with other medicines:

Medicine is applied with care along with other medicines as both strengthening of their specific activity, and strengthening of their toxicity is possible. However, use of this medicine in combination with heparin, antibiotics and NPVS is possible.

Increases absorption and increases effect of other locally applied medicines.

Increases hypersensitivity of microorganisms to aminoglycosides and beta лактамным to antibiotics, chloramphenicol, rifampicin, griseofulvin.

Strengthens action and increases absorption of ethanol, insulin.

Sensibilizes an organism to effect of medicines for the general and local anesthesia.


Contraindications:

Hypersensitivity to a dimethyl sulfoxide, disturbance of functions of a liver and/or kidneys, the expressed cardiovascular insufficiency, the expressed atherosclerosis, stenocardia, glaucoma, a cataract, a myocardial infarction, a stroke, a coma, children's age up to 6 years, pregnancy the lactation period.


Overdose:

It is possible at high concentration. System effects include injuries of a GIT, drowsiness, a headache. Strengthening of dozozavisimy side effects is possible. In these cases medicine it is necessary to cancel, wash out the damaged place, a symptomatic treatment. At accidental poisoning through a GIT it is necessary to wash out quickly a stomach, however it is necessary to remember that Dimexidum is quickly soaked up.


Storage conditions:

To store in the place protected from moisture and light at a temperature not above +25 °C. To store in the place, unavailable to children. Period of storage 3 years.


Issue conditions:

Without recipe


Packaging:

On 60,0ml and 100,0 ml in bottles plastic, corked by caps polymeric screw, placed together with a leaf insert for the consumer in a pack from a cardboard.



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