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medicalmeds.eu Medicines Glucocorticoid + Keratolitik. Дипросалик®

Дипросалик®

Препарат Дипросалик®. Merck Sharp & Dohme Corp. (Мерк Шарп и Доум Корп.) США


Producer: Merck Sharp & Dohme Corp. (Merck Sharp and Doum of the Building) USA

Code of automatic telephone exchange: D07XC01

Release form: Soft dosage forms. Ointment.

Indications to use: Psoriasis. Atopic dermatitis. Neurodermatitis. Deprive. Monetovidny eczema. Eczema. Dermatitis. Seborrheal dermatitis. Ichthyosis.


General characteristics. Structure:

Active ingredients: 640 mkg of betamethasone of Dipropionas (that makes 500 mkg of betamethasone), 30 mg of salicylic acid.

Excipients: liquid paraffin, vaseline.




Pharmacological properties:

Pharmacodynamics. Ointment Diprosalik represents the combined drug on the basis of two active agents - betamethasone of Dipropionas and salicylic acid.

Betamethasone Dipropionas - the synthetic fluorinated GKS - has antiinflammatory, antipruritic and vasoconstrictive effect.

At topical administration salicylic acid possesses keratolytic, and also bacteriostatic and some fungicidal action.


Indications to use:

Ointment Diprosalik is shown for reduction of inflammatory manifestations of a dry and giperkeratichesky dermatosis sensitive to therapy of GKS, including:

psoriasis;

— chronic atopic dermatitis;

neurodermatitis (chronic simple depriving);

— flat depriving;

eczemas (including monetovidny eczema, eczema of hands, eczematic dermatitis);

— dyshydrosis;

— seborrheal dermatitis of a pilar part of the head;

ichthyosis and other ikhtiozopodobny states.


Route of administration and doses:

Diprosalik it is necessary to apply ointment a thin layer 2 times a day - in the morning and for the night, completely covering affected areas of skin. At some patients of the supporting effect it is possible to reach less frequent applications.


Features of use:

Use at pregnancy and feeding by a breast. Because safety of use of local GKS for pregnant women is not established, purpose of this class of medicines during pregnancy is justified only if the expected advantage for mother surpasses potential risk for a fruit.

Drugs of this class should not be used during pregnancy in high doses or long time.

Whether as it is not revealed so far the level of system absorption of local GKS is sufficient for emergence of their defined concentration in mother's milk, it is necessary or to stop feeding by a breast, or drug use, considering as far as it is necessary for mother.

Use for children. Drug can be used with care at children aged from 2 years.

Special instructions. If against the background of ointment use Diprosalik the irritation or a hyper sensitization developed, treatment should be stopped.

In case of accession of an infection it is necessary to appoint the corresponding therapy.

At topical administration of GKS, especially at children, the side effects characteristic of system GKS, including function oppression гипоталамо - pituitary and adrenal system can be noted.

System absorption of GKS and salicylic acid at topical administration will be higher when using occlusive bandages, and also in case of use on extensive body surfaces.

At prolonged treatment by drug its cancellation is recommended to be carried out gradually.

Ointment Diprosalik is not intended for use in ophthalmology. It is necessary to avoid hit in eyes and on mucous membranes.

Use in pediatrics. Drug can be used with care at children aged from 2 years.

Children are more subject to risk of oppression of function гипоталамо - pituitary and adrenal system owing to use of local GKS, than adults, because of a bigger ratio of body surface area at them both weight and, respectively, the increased drug absorption.

There were messages on depression of function гипоталамо - pituitary and adrenal system, Cushing's syndrome, a growth inhibition, an insufficient gain of body weight and increase in intracranial pressure for the children receiving GKS for topical administration. Function oppression гипоталамо - pituitary and adrenal system at children is defined by the low level of cortisol in plasma and lack of the response to stimulation of adrenocorticotropic hormone. Increase in intracranial pressure is shown by protrusion of a fontanel, headaches, a bilateral papilledema.


Side effects:

The undesirable phenomena which met when using local GKS included burning, an itch, irritation, a xeroderma, a folliculitis, a hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. The following phenomena arose at use of occlusive bandages more often: maceration of skin, consecutive infection, atrophy of skin, striya and heat rash.

Drugs of salicylic acid can cause dermatitis.

At emergence of the side reactions which are not described in the present instruction it is necessary to see a doctor.



Contraindications:

— the instruction on the reaction increased sensitivity to any of ointment components in the anamnesis.


Overdose:

Excessive and long use of GKS for topical administration can cause the oppression of function of gipofizo-adrenal system leading to secondary insufficiency of function of adrenal glands and the phenomena of a hypercorticoidism including Cushing's syndrome.

The corresponding symptomatic treatment is shown. Acute symptoms of a hypercorticoidism are usually reversible.


Storage conditions:

To store in the place, dark, unavailable to children, at a temperature from 2 to 30 °C. A period of validity - 5 years from the date of production.


Issue conditions:

According to the recipe


Packaging:

30 g - tubas aluminum (1) - packs cardboard.



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