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medicalmeds.eu Medicines Antifungal means. Candide (powder for external use)

Candide (powder for external use)

Препарат Кандид (порошок для наружного применения). Glenmark Pharmaceuticals Ltd.(Гленмарк Фармасьютикалз Лтд) Индия


Producer: Glenmark Pharmaceuticals Ltd. (Glenmark Pharmasyyutikalz Ltd) India

Code of automatic telephone exchange: G01AF02

Release form: Firm dosage forms. Powder.

Indications to use: The erosion is interdigital. Skin mycoses. Multi-colored (scaly) deprive. Erythrasma.


General characteristics. Structure:

Active agent: Clotrimazolum of 10,0 mg.

Excipients: the talc purified 925,0 mg starch of corn 50,0 mg, silicon dioxide of colloid 10,0 mg, a fragrance of cosmetic 5,0 mg.




Pharmacological properties:

Pharmacological action - antifungal broad-spectrum agent for topical administration, antibacterial, antiprotozoan, trikhomonatsidny.
The anti-mycotic effect of active active ingredient of Clotrimazolum (derivative an imidazole) is connected with disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms that changes permeability of a membrane and the subsequent lysis of a cell causes. In fungicidal concentration interacts with mitochondrial and peroksidazny enzymes therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that also promotes destruction of fungal cells. Shows fungicidal and fungistatic activity concerning dermatomitset (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), drozhzhepodobny and mold mushrooms (Candida spp., including Candida albicans; Torulopsis glabrata, sorts Rhodotorula, Pityrosporum orbiculare). It is active concerning the activator multi-colored depriving – Pityrosporum orbiculare (Malassezia furfur). It is effective concerning gram-positive bacteria – Corynebacterium minutissimum erythrasma activator, and also Staphylococcus spp., Streptococcus spp., gram-negative bacteria – Bacteroides, Gardnerella vaginalis. In high concentration it is active concerning Trichomonas vaginalis.

Pharmacokinetics. Absorption. At external use Clotrimazolum is badly soaked up through skin. Bioavailability makes less than 0,5%.
Distribution
The minimum overwhelming concentration (MOC) for the majority of a pathogenic fungi (50 – 100 mkg/ml) collects in a corneous layer of epidermis in concentration above, than. Concentration in a basal layer of epidermis makes 1,53 – 3 mkg/ml.
Gets into a keratin of nails.

Metabolism and removal. In a liver it biotransformirutsya to inactive metabolites and it is removed through intestines.
It is removed through kidneys (the share of renal excretion makes 0,05% - 0,5%). The elimination half-life of initial substance makes 3,5 – 5 hours.


Indications to use:

- fungal infections of skin
- interdigital fungal erosion
- the mycoses complicated by consecutive infection
- multi-colored deprive
- erythrasma.


Route of administration and doses:

Outwardly. It is applied on previously cleared and dry sites of skin twice a day (in the morning and in the evening). Candide powder can be also sprayed on the clothes or footwear which are in direct contact with affected areas. Candide powder can be applied in combination with Candide's drugs cream for external use of 1% or Candide solution to external use of 1%. Duration of therapy is individual and depends on weight and localization of a disease. For achievement of an absolute recovery it is not necessary to stop treatment by drug at once after disappearance of acute symptoms of an inflammation or subjective complaints. Duration of therapy has to make, on average, about 3 - 4 weeks. Regular use of drug is important for successful treatment.


Features of use:

- drug is intended only for external use;
- to avoid hit in eyes;
- to use drug for children 2 years only under the supervision of the doctor are younger;
- at an accidental proglatyvaniye see a doctor.
Drug does not influence ability to manage vehicles and to be engaged in other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Influence on ability to manage cars/mechanisms
Drug does not influence ability to manage vehicles and mechanisms.


Side effects:

At topical administration on skin (seldom): erythema, pricking, burning, irritation, itch, urticaria, hypostasis. If any of the side effects specified in the instruction are aggravated, or you noticed any other side effects which are not specified in the instruction, report about it to the doctor.


Interaction with other medicines:

Clotrimazolum reduces activity of Amphotericinum In and other half-yen antibiotics. At simultaneous use with natamitsiny and nystatin activity of Clotrimazolum can decrease.


Contraindications:

- hypersensitivity to Clotrimazolum or other components of drug
- I trimester of pregnancy.

Use at pregnancy and during breastfeeding
At clinical and pilot studies it was not established that use of drug during pregnancy or during feeding by a breast exerts negative impact on health of the woman or a fruit (child). However the question of expediency of purpose of drug in II or the III trimester has to be solved individually after consultation with the doctor. At purpose of drug during II or III trimesters of pregnancy it is necessary to consider a ratio of estimated advantage of purpose of drug for mother and possible risk for a fruit. Putting drug directly on the lactating chest gland is contraindicated.


Overdose:

The overdose is improbable.


Storage conditions:

In the dry, protected from light place at a temperature from 2 °C to 25 °C.
To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Powder for external use of 10 mg/g.
On 30 g of powder in the plastic bottle which is closed the polyethylene stopper supplied with openings with a paper sticker. The bottle is closed by a plastic cap. On 1 bottle with the application instruction place in a cardboard pack.



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