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Myeloid metaplasia


The myeloid metaplasia is the pan-proliferative process which is followed by proliferation of connecting tissue of marrow, spleen and lymph nodes with simultaneous proliferation of hemopoietic elements in a liver, a spleen and tubular bones.

Reasons of a myeloid metaplasia:

The reason is unknown. Increase in a spleen can be observed. Emergence of portal hypertensia can be caused by either fibrosis of a liver, or increase in a hepatotropic blood-groove.

Symptoms of a myeloid metaplasia:

The clinical picture is usually characterized by anemia and the increasing splenomegaly. Symptoms include the abdominal pain caused by a spleen heart attack, feeling of weight after food, spontaneous bleeding, consecutive infection, an ostealgia, an itch and a hyperuricemia. Often note a hepatomegalia.
Diagnostic criterion — a smear of peripheral blood. Note presence of the fragmented erythrocytes with a poikilocytosis, cells of "the falling tear" and lengthening of their form. The quantity of leukocytes usually makes less than 50 000, but can be much higher. The quantity of thrombocytes can be low, normal or high.

Миелоидная метаплазия в синусах лимфатической железы при миелоиднои лейкемии.

Myeloid metaplasia in sine of lymphatic gland at myeloid leukemia.

Treatment of a myeloid metaplasia:

Treatment consists in use of transfusions, hormones, chemotherapy and radiation therapy. Use бусульфан and cyclophosphamide.
The splenectomy, though is not radical, is shown for the control of anemia, thrombocytopenia and secondary symptoms caused by increase in a spleen. At the patients having varicose expanded veins of a gullet, the splenectomy can demand the accompanying performance of portal system shunting as after a splenectomy the level of portal pressure remains high. The thrombosis which developed in the postoperative period and fibrinferments of a splenic vein, spreading to portal and mezenterialny veins, is noted at these patients more often. Operational mortality makes 13%, the frequency of complications — 45%.

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