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medicalmeds.eu Medicines The means operating on respiratory system. Supragistim - Darnitsa, solution for and 2% on 1 ml No. 5

Supragistim - Darnitsa, solution for and 2% on 1 ml No. 5

Препарат Супрагистим - Дарница, р-р д/и 2% по 1 мл №5. ЗАО "Фармацевтическая фирма "Дарница" Украина


Producer: CJSC Pharmaceutical Firm Darnitsa Ukraine

Code of automatic telephone exchange: R06AC03

Release form: Liquid dosage forms. Solution for injections.

Indications to use: Small tortoiseshell. Serum disease. Hay fever. Rhinitis (cold). Conjunctivitis. Quincke's disease of Quincke. Neurodermatitis. Contact dermatitis. Toksikodermiya.


General characteristics. Structure:

International and chemical name: Chloropyramine; N, N-dimetil-N-(n-chlorobenzylium) - N "-(2-piridit) ethylene diamine a hydrochloride 
main physical and chemical properties: transparent colourless liquid.
Structure: 1 ml hydrochloride Chloropyraminum (in terms of 100% anhydrous substance) 0,02 g; 
Excipients: water for injections.




Pharmacological properties:

Pharmacological H1 receptors Blocker; derivative ethylene diamine. Prevents development and facilitates the course of allergic reactions. Except antiallergic renders the sedative and expressed to a protizudn actions. Has peripheral anticholinergic activity, moderate spasmolytic properties.

Pharmacokinetics. Therapeutic level of concentration remains 4-6 hours. It is evenly distributed in bodies and fabrics, gets through a blood-brain barrier. It is intensively metabolized in a liver and removed by kidneys and through intestines.
INDICATIONS are Appointed at allergic diseases (including a small tortoiseshell, a serum disease, hay fever, rhinitis, conjunctivitis, a Quincke's disease; skin diseases including neurodermatitis, contact dermatitis and toksikodermiya); allergies at п


Indications to use:

Appoint at allergic diseases (including a small tortoiseshell, a serum disease, hay fever, rhinitis, conjunctivitis, a Quincke's disease; skin diseases including neurodermatitis, contact dermatitis and toksikodermiya); allergies at reception of medicines; to bronchial asthma of an easy current (as a part of complex therapy).


Route of administration and doses:

At hard and acute cases of allergic and anaphylactic reactions of Supragistim-Darnits enter intravenously, then intramusculary the adult administer the drug intravenously or intramusculary on 1-2 ml (20-40 mg hydrochloride Chloropyraminum). The initial dose of Supragistimu-Darnits for children aged from 1 month till 1 year makes 0,1 ml to 0,25 ml of solution (2-5 mg hydrochloride Chloropyraminum), from 1 year to 6 years - 0,5 ml of solution (10 mg hydrochloride Chloropyraminum), from 6 to 14 years - 0,5-1 ml (10-20 mg hydrochloride Chloropyraminum). Further therapy and/or increase in a dose substantially is defined by existence of side effects. The maximum daily dose makes 2 mg/kg of body weight.
Course of treatment - from 1 to 14 days. In some cases the course of treatment is established individually (from 1 to 28 days).


Features of use:

During Supragistimu-Darnits's use alcohol intake is forbidden. Children should appoint drug with care for hypersensitivity of this category of patients to antihistamines of drugs. In the initial, individually defined period of use of Supragistimu-Darnits it is not allowed to manage vehicles and to be engaged in other potentially dangerous types of activity demanding speed of psychomotor reactions. In the course of further treatment extent of restriction is defined depending on individual portability of drug.


Side effects:

Drowsiness, dizziness, incoordination are possible. From the alimentary system: dryness in a mouth, nausea.


Interaction with other medicines:

At simultaneous use exponentiates effects of anesthetics, hypnotic drugs, sedative drugs, and also opioid analgetics and local anesthetics.
At simultaneous use of Supragistimu-Darnits and caffeine or Phenaminum reduction or elimination of oppressing Supragistimu-Darnits's action by the central nervous system is noted. On TsNS it can be applied to prevention or elimination of oppressing Supragistimu-Darnits's action in combination with drugs of caffeine or Phenaminum.

As a result of combined use with tricyclic antidepressants strengthening M-holinoblokiruyushchego of action, and also the oppressing action on the central nervous system is possible.


Contraindications:

Glaucoma; benign hyperplasia of a prostate; urination delay; a peptic ulcer of a stomach in an aggravation phase; concomitant use of MAO inhibitors, pregnancy, lactation period; do not apply to children up to 1 month, hypersensitivity to drug components, to other derivatives of ethylene diamine.


Overdose:

Symptoms. Children have an excitement, concern, hallucinations, an ataxy, an athetosis, spasms, a mydriasis and an immovability of pupils, a dermahemia of the person, a hyperthermia, and then - a vascular collapse, a coma. Adults have a block, a depression, psychomotor excitement, spasms, is rare - a hyperthermia and a hyperemia of integuments, then - a coma.
Treatments. According to indications - anticonvulsants, artificial ventilation of the lungs and other resuscitation actions.


Storage conditions:

To store in the place protected from light at a temperature from 8 ° up to 25 °C.

Period of validity 2 years.


Issue conditions:

According to the recipe


Packaging:

On 1 ml in an ampoule. On 5 or 10 ampoules in packaging.



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