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medicalmeds.eu Medicines Antifungal means. Candide cream

Candide cream

Препарат Кандид крем. Glenmark Pharmaceuticals Ltd.(Гленмарк Фармасьютикалз Лтд) Индия


Producer: Glenmark Pharmaceuticals Ltd. (Glenmark Pharmasyyutikalz Ltd) India

Code of automatic telephone exchange: D10AC01

Release form: Soft dosage forms. Cream.

Indications to use: Skin mycoses. Multi-colored (scaly) deprive. Erythrasma.


General characteristics. Structure:

Active agent: Clotrimazolum of 10,0 mg.

Excipients: propylene glycol of 50,0 mg, vaseline of white 120,0 mg, paraffin of liquid 60,0 mg, wax of emulsion tsetomakrogolny 135,0 mg, benzyl alcohol of 10,0 mg, methylparahydroxybenzoate of 1,5 mg, пропилпарагидроксибензоат 0,5 mg, butyl hydroxytoluene of 1,0 mg, dihydrophosphate sodium a dihydrate of 0,8 mg, sodium hydrophosphate of 0,6 mg, the water purified to 1000 mg.




Pharmacological properties:

Pharmacological action - protivobgribkovy broad-spectrum agent for topical administration, antibacterial, antiprotozoan, trikhomonatsidny.
The anti-mycotic effect of active active ingredient of Clotrimazolum (derivative an imidazole) is connected with disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms that changes permeability of a membrane and the subsequent lysis of a cell causes. In fungicidal concentration interacts with mitochondrial and peroksidazny enzymes therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that also promotes destruction of fungal cells. Shows fungicidal and fungistatic activity concerning dermatomitset (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), drozhzhepodobny and mold mushrooms (Candida spp., including Candida albicans; Torulopsis glabrata, sorts Rhodotorula, Pityrosporum orbiculare). It is active concerning the activator multi-colored depriving – Pityrosporum orbiculare (Malassezia furfur). It is effective concerning gram-positive bacteria – Corynebacterium minutissimum erythrasma activator, and also Staphylococcus spp., Streptococcus spp., gram-negative bacteria – Bacteroides, Gardnerella vaginalis. In high concentration it is active concerning Trichomonas vaginalis.

Pharmacokinetics. Clotrimazolum is badly soaked up through skin and mucous membranes and has practically no systemic action. Concentration in deep layers of epidermis is higher than the minimum overwhelming concentration for dermatophytes.
At external use concentration of Clotrimazolum in epidermis is higher, than in a derma and hypodermic cellulose.


Indications to use:

- fungus diseases of skin, mycoses of skin folds, feet;
- the chromophytosis, an erythrasma, superficial candidiases caused by dermatophytes, barmy (including the sort Candida), the mold and other mushrooms and activators sensitive to Clotrimazolum;
- the mycoses complicated by a secondary pyoderma.


Route of administration and doses:

Outwardly. Cream is applied with a thin layer by 2-3 times a day on previously cleared (using soap with neutral value рН) and the dried-up affected areas of skin and carefully rub.
Duration of treatment depends on disease severity, localization of pathological changes and efficiency of therapy. Treatment of dermatomycoses is carried out by not less than 4 weeks, a chromophytosis - 1-3 weeks.
At fungus diseases of skin of legs therapy is recommended to be continued within not less than 2 weeks after elimination of symptoms of a disease.


Features of use:

Putting drug on skin in eyes is not recommended.
At patients with a liver failure it is necessary to control a functional condition of a liver periodically.
At emergence of signs of hypersensitivity or irritation treatment is stopped.
In the absence of effect within 4 weeks it is necessary to confirm the diagnosis.

Influence on ability to manage vehicles and mechanisms
Drug does not influence ability to manage vehicles and mechanisms.


Side effects:

Allergic reactions in the form of an itch, a small tortoiseshell, burning, a pricking in cream sites of application. Emergence of an erythema, blisters, hypostasis, irritation and a peeling of skin is possible.

With care
Lactation period.


Interaction with other medicines:

Amphotericinum In, nystatin, натамицин reduce efficiency of Clotrimazolum at simultaneous use.
At cream use negative interactions with other means are not known and they should not be expected since rezorbtsionny ability of Clotrimazolum very low.


Contraindications:

- hypersensitivity to Clotrimazolum or other components of drug
- I trimester of pregnancy.

Use at pregnancy and during breastfeeding
At clinical and pilot studies it was not established that use of drug during pregnancy or during feeding by a breast exerts negative impact on health of the woman or a fruit (child). However the question of expediency of purpose of drug in II or the III trimester has to be solved individually after consultation with the doctor. At purpose of drug during II or III trimesters of pregnancy it is necessary to consider a ratio of estimated advantage of purpose of drug for mother and possible risk for a fruit. Putting drug directly on the lactating mammary gland is contraindicated.


Overdose:

Use of cream in the raised doses does not cause any reactions and states, life-threatening.


Storage conditions:

In the dry, protected from light place at a temperature from 2 °C to 25 °C.
To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Cream for external use of 1%.
On 20 g of drug in an aluminum tuba with the screwing-up plastic cover supplied with an edge for piercing of a protective membrane. One tuba together with the application instruction in a cardboard pack.



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