Sulfacylum-natrium of 20%

General characteristics. Structure:

Active ingredient: 200 mg of Sulfacetamidum natricum in 1 ml of solution.

Pharmacological properties:

Pharmacodynamics. Possesses bacteriostatic action. The mechanism of action is connected with competitive antagonism with PABK and oppression of a digidropteroatsintetaza that leads to disturbance of synthesis of the tetrahydrofolic acid necessary for synthesis of purines and pyrimidines.

It is active concerning gram-positive and gram-negative bacteria (including colibacillus, streptococci, gonokokk, pneumococci), and also chlamydias, actinomycetes.

Pharmacokinetics. At topical administration gets into fabrics and liquids of an eye. Can get into a system blood stream through the inflamed conjunctiva, however because of insignificant amount of drug the system effect is not defined.

Indications to use:

Indications to use of drug are: purulent helcomas; conjunctivitis; blepharites; gonorrheal diseases of eyes at newborns and adults; prevention of a blennorea at newborns.

Route of administration and doses:

Drug is dug in in a conjunctival sac on 1 - 2 drops of solution (10-20 mg of Sulfacetamidum natricum) of 5 — 6 times a day, to children dug in on 1 drop of solution (10 mg of Sulfacetamidum natricum) of 3 — 6 times a day. For prevention of a blennorea at newborns dig in on 1 drop of solution (10 mg of Sulfacetamidum natricum) in each eye three times with an interval of 10 minutes.

Features of use:

At patients with the increased individual sensitivity to the furosemide, thiazide diuretics derivative of sulphonylurea or inhibitors of carboanhydrase it can be shown raised чувствительнось to a sodium sulfacetamide.

With care appoint to patients with burdened allergoanamnezy.

Side effects:

At use of drug are possible local irritation of fabrics (short-term burning, reddening, swelled, allergic reactions).

Interaction with other medicines:

Combined use with Procainum and pantocain reduces bacteriostatic effect of a sulfacetamide of sodium. Incompatibility of a sulfacetamide of sodium at its combined use with silver salts is observed.

Contraindications:

The increased individual sensitivity to sulfanamide drugs.

Overdose:

Symptoms: irritation of fabrics (burning, reddening, hypostasis, gripes, dacryagogue).

Treatment: it is necessary to reduce a drug dose, to increase an interval between use of eye drops or to cancel drug.

Issue conditions:

According to the recipe

Packaging:

Solution (drops eye) 200 mg/ml in a tube droppers of 1 ml in packaging No. 2, in bottles of 5 ml.