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medicalmeds.eu Medicines Antiviral means for system use. Amizonchik

Amizonchik

Препарат Амизончик. ОАО "Фармак" Украина


Producer: JSC Pharmak Ukraine

Code of automatic telephone exchange: J05AX

Release form: Liquid dosage forms. Syrup.

Indications to use: SARS. Flu.


General characteristics. Structure:

Active ingredient: амизон® (энисамиум iodide);

1 ml of syrup contains амизона® (an enisamiuma of iodide) 10 mg;

excipients: sodium hydrophosphate, dodecahydrate; citric acid, monohydrate; Tutti-Frutti fragrance; Peach fragrance; yellow decline of FCF (E 110); the water purified; sorbite the solution which is not crystallizing (Е 420).




Pharmacological properties:

Enisamium iodide – derivative isonicotinic acid. Carries out the inhibiting influence on influenza viruses, shows interferonogenny properties, increases resistance of an organism to viral infections, possesses antiinflammatory, febrifugal and analgetichesky action.

Antiviral action of Amizonchik is connected with his direct influence on influenza virus gemaglyutinina owing to what virion loses ability to join target cells for further replication.

Antiinflammatory action is result of stabilization of cellular and lizosomalny membranes, delays of degranulation of basophiles, antioxidant action, normalization of level of prostaglandins, cyclic nucleotides and energy balance in the inflammation center. Febrifugal properties of this means are caused by influence on the temperature-controlled centers of a brain. The analgesic effect of drug is carried out by means of a reticular formation of a brainstem.

Enisamium iodide increases persistent immunity by increase in level of endogenous interferon in a blood plasma by 3-4 time, a lysozyme and increase in an antiserum capacity to causative agents of infections, and also cellular immunity – due to stimulation of functional activity of T lymphocytes and macrophages. This means is the powerful inductor of endogenous interferon.

After oral administration энисамиум iodide quickly gets to blood, its maximum concentration in blood is observed in 2-2,5 h after reception. The elimination half-life makes 13,5-14 h. Drug is metabolized in a liver, but quickly removed from fabrics (the elimination half-life makes 2-3 h). It is brought out of an organism for 90 – 95% with urine in the form of metabolites.


Indications to use:

Treatment of flu and SARS.


Route of administration and doses:

Drug is recommended for treatment of children 3 years are more senior. Syrup is accepted inside, it is desirable after food, washing down with a small amount of water.

Children from 3 to 4 years – on 5 ml (50 mg) 3 times a day.

Children from 4 to 5 years – on 6 ml (60 mg) 3 times a day.

Children from 5 to 6 years – on 7 ml (70 mg) 3 times a day.

To children aged from 6 up to 12 years drug is appointed in the form of tablets. If the child cannot swallow of tablets, drug is accepted on 12 ml (120 mg) by 2-3 times a day.

Not to exceed the recommended doses.

For dosing of syrup the dosing spoon of 5 ml with scale interval of 1 ml is applied. If it is necessary to measure a dose more than 5 ml, measure at first the first 5 ml of syrup, and then the dose rest.

The course of treatment makes 5-7 days depending on disease severity and therapeutic effect.


Features of use:

Appropriate security measures at use

It is necessary to appoint carefully drug to patients with diseases of a thyroid gland especially at a hyperthyroidism.

Syrup contains sorbite therefore patients with rare hereditary intolerance of fructose should not accept this drug. Sorbite can also have insignificant laxative effect.

Use during pregnancy or feeding by a breast. Drug is not intended for use to these categories of patients.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Drug is not intended for use of this category of patients.

Children. Drug is used for treatment of children 3 years are more senior.


Side effects:

Allergic reactions: hypersensitivity reactions, including skin rashes, a small tortoiseshell, a Quincke's disease, an itch.

From system of digestion: dryness and bitterness in a mouth, swelled a mucous membrane of an oral cavity, hypersalivation, coloring of language in yellow color, nausea, vomiting, heartburn, an abdominal pain, weight in right hypochondrium, a diarrhea, abdominal distention.

From system of breath: an asthma, a burning sensation in a throat.

Others: headache, dizziness, weakness, fluctuation of arterial pressure.


Interaction with other medicines:

Amizonchik strengthens action antibacterial and immunomodulators. The combination of this drug with ascorbic acid and other vitamins is reasonable. Also Amizonchik it is possible to appoint along with drugs of recombinant interferon.


Contraindications:

Hypersensitivity to components of drug and drugs of iodine.
Existence of allergic reactions irrespective of the allergen nature in the anamnesis.
Crushing organic lesions of a liver and kidneys.


Overdose:

At overdose strengthening of manifestations of side reactions is possible: coloring of mucous membranes in brown color, vomiting, an abdominal pain and diarrhea. Development of hypostases, an erythema, ugrepodobny and violent rashes, fevers is possible.

Treatment: gastric lavage, symptomatic treatment.


Storage conditions:

Period of validity 2 years. A drug period of storage after opening of a bottle – 90 days. Not to use drug after the termination of the period of validity specified on packaging. To store in the place protected from light at a temperature not over 25 ºС. To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

On 100 ml in a bottle. On 1 bottle and 1 dosing spoon in a pack.



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