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medicalmeds.eu Medicines Somnolent and sedative drugs. The combined drugs of barbiturates. Korvatablet

Korvatablet

Препарат Корватаблет. АО "Химфарм" Республика Казахстан


Producer: JSC Himfarm Republic of Kazakhstan

Code of automatic telephone exchange: N05CB02

Release form: Firm dosage forms. Tablets.

Indications to use: Neurosis. Nervous irritability. Sleeplessness (insomniya). Neurocirculatory dystonia. Tachycardia. Koronariit. Symptomatic arterial hypertension.


General characteristics. Structure:

Active agents: ethyl ether-bromine-isovaleric acid of 8.20 mg (additional dose) (1.64) mg, phenobarbital of 7.50 mg.

Excipients: oil mint, a β-cyclodextrin, lactoses monohydrate, microcrystallic cellulose, sodium of starch glikolit, silicon dioxide colloid (aerosil), calcium stearate.




Pharmacological properties:

Pharmacokinetics. After administration of drug inside phenobarbital almost completely, but is rather slowly soaked up in a small intestine.

The peak of concentration in blood is observed in 1 - 2 h after reception. About 50% communicate proteins of plasma. Drug is evenly distributed in different bodies and fabrics; its smaller concentration are found in brain tissues. It is allocated from an organism slowly that creates premises for cumulation. Bioavailability makes 80%. Half-life makes 2-4 hours.

It is metabolized by microsomal enzymes of a liver. The inactive metabolite (4 oxyphenobarbital) is allocated with kidneys in the form of a glucuronide, and about 25% - in not changed look.

Oil of mint peppery after absorption biotransformirutsya in a liver and is emitted with urine and bile in the form of glucuronides.

Pharmacodynamics. Корватаблет® - the combined drug. Renders calming and an antispasmodic.

Ethyl ether-bromine-isovaleric acid possesses sedative, spasmolytic action, contributes to normalization of a sleep pattern and wakefulness, improves a night dream. Besides, at use of drug improvement of coronary circulation is noted. The mechanism of effect of drug is connected with ability to oppress the central nervous system, including braking of systems oblong both a mesencephalon and increase in functional mobility of cortical processes is noted. Effect of drug on heart is carried out as it is mediated through the central nervous system, and by direct influence on coronary vessels.

Phenobarbital renders the expressed sedative, vasodilating, somnolent action.


Indications to use:

- neurosises with an acrimony

- hyperexcitability

- sleeplessness, including backfilling disturbance

- neurocirculatory dystonia

- tachycardia

- spasm of coronary vessels (unsharply expressed)

- early stages of an arterial hypertension

- the spasms of bodies of a digestive tract caused by neurovegetative frustration


Route of administration and doses:

Inside, before food, the adult, appoint 1-2 tablets of drug 2-3 times a day. At tachycardia and spasms of coronary vessels the single dose can be increased to 3 tablets.

The maximum single dose – 3 tablets.

Drug is intended for short-term use.

The dosage and duration of a course of treatment is defined by the doctor individually for each patient.


Features of use:

During administration of drug it is not necessary to take alcohol.

During treatment it is necessary to abstain from occupations potentially dangerous activity demanding concentration of attention and speed of psychomotor reactions.


Side effects:

- drowsiness

- dizziness

- decrease in concentration of attention

- allergic reactions (skin rash, itch)


Interaction with other medicines:

Drug strengthens effect of sedative drugs, neuroleptics, tranquilizers, alcohol. Effect of drug amplifies against the background of use of drugs of valproic acid.


Contraindications:

- hypersensitivity to drug components

- the expressed renal failures and/or a liver

- alcoholism

- drug addiction

- myasthenias

- children's and teenage age up to 18 years

- pregnancy and period of a lactation


Overdose:

Symptoms - are possible drowsiness, weakness, dizziness.

Treatment: termination of administration of drug, gastric lavage and symptomatic therapy. There is no specific antidote.


Storage conditions:

To store in the dry, protected from light place, at a temperature not above 25 °C.

 

To store in the place, unavailable to children! 


Issue conditions:

Without recipe


Packaging:

On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil.

On 2 or 10 blister strip packagings together with the approved instruction on a medical use in the state and Russian languages place in a pack from a cardboard.



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