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medicalmeds.eu Medicines Mucolytic means. Бромгексин-Акри®

Бромгексин-Акри®

Препарат Бромгексин-Акри®. ОАО "Химико-фармацевтический комбинат "АКРИХИН" Россия


Producer: JSC Chemical and Pharmaceutical Plant AKRIKHIN Russia

Code of automatic telephone exchange: R05CB02

Release form: Liquid dosage forms. Syrup.

Indications to use: Bronchial asthma. Tuberculosis. Pneumonia. Tracheobronchitis. Bronchitis. Bronchiectasias. Mucoviscidosis. Chronic obstructive bronchitis. Emphysema of lungs. Pneumoconiosis. Postoperative period.


General characteristics. Structure:

Active ingredient: 0,08 mg of Bromhexine of a hydrochloride in 100 ml of syrup.

Excipients: propylene glycol, sorbite food powdery, the benzoic acid, menthol, citric acid, saccharin soluble, vanillin, tropeolin Oh, of essence aromatic food or fragrances food, the water purified.




Pharmacological properties:

Pharmacodynamics. Drug renders mucolytic (sekretolitichesky) and expectorant action. The mucolytic effect is connected with a depolymerization and fluidifying of mucoprotein and mukopolisakharidny fibers. Bromhexine has weak antibechic effect. Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath. The clinical effect is shown in 2-5 days from an initiation of treatment by drug.

Pharmacokinetics. At intake Bromhexine almost completely (99%) is soaked up within 30 minutes. Bioavailability makes 80% (effect of "the first passing" through a liver). In plasma Bromhexine contacts proteins, gets through hematoencephalic and placental barriers. In a liver Bromhexine is exposed to demethylation and oxidation.

The elimination half-life makes 15 h owing to slow return diffusion of fabrics. It is removed by kidneys. At a chronic renal failure allocation of metabolites of Bromhexine is broken. At repeated use Bromhexine can kumulirovat.


Indications to use:

The bronchopulmonary diseases which are followed by formation of a phlegm of the increased viscosity (bronchial asthma, a mucoviscidosis, tuberculosis, pneumonia, a tracheobronchitis, obstructive bronchitis, bronchiectasias, emphysema of lungs, a pneumoconiosis) before - and the postoperative period.


Route of administration and doses:

Bromhexine Acre ® is accepted inside irrespective of meal. The adult appoint 8-16 mg (10-20 ml) 3-4 times a day; to children up to 2 years — on 2 mg (2,5 ml) 2-3 times a day, from 2 to 6 years — on 2-4 mg (2,5-5 ml) 3 times a day, from 6 to 14 years — 4-8 mg (5-10 ml) 3 times a day. A course of treatment — from 4 to 28 days.

In the course of treatment it is recommended to use enough liquid that supports sekretolitichesky action of Bromhexine.

At children treatment should be combined with postural drenazhy or the vibration massage of a thorax facilitating evacuation of a secret from bronchial tubes.



Side effects:

Seldom, at long administration of drug nausea, vomiting, the dis-pepsichesky phenomena, dizziness, a headache, an aggravation of a peptic ulcer, allergic reactions (skin rash, rhinitis, etc.), increase in level of "hepatic" transaminases in blood serum are possible. In these cases it is necessary to cancel drug.


Interaction with other medicines:

Бромгексин-Акри® it is possible to appoint along with other drugs used at treatment of bronchopulmonary diseases.

Бромгексин-Акри® do not appoint along with the medicines containing codeine as it complicates expectoration of the liquefied phlegm.

Бромгексин-Акри® promotes penetration of antibiotics (erythromycin, cefalexin, Oxytetracyclinum) into pulmonary fabric.

Бромгексин-Акри® it is not compatible to alkaline solutions.


Contraindications:

- hypersensitivity to drug components;
- pregnancy (1 trimester);
- lactation period;
- a peptic ulcer (in an aggravation stage).

With care Bromhexine Acre ® should be applied at the weakened patients; with gastric bleeding in the anamnesis, a renal and/or hepatic ndostatochnost, and also patients with diseases of the bronchial tubes which are followed by excessive accumulation of a secret.


Overdose:

Symptoms: nausea, vomiting, diarrhea, dispepsichesky frustration.

Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).


Storage conditions:

In the dry, protected from light place unavailable to children, at a temperature from 12 to 15 °C. Not to use after the date specified on packaging. A period of validity - 3 years.


Issue conditions:

Without recipe


Packaging:

On 60, 80, 100 or 120 ml in bottles of orange glass with a measured spoon and the application instruction place in a pack from a cardboard.



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