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medicalmeds.eu Medicines Protivoparkinsonichesky means. Midantanum

Midantanum

Препарат Мидантан. ОАО "Борисовский завод медицинских препаратов" Республика Беларусь


Producer: JSC Borisovsky Plant of Medical Supplies Republic of Belarus

Code of automatic telephone exchange: N04BB01

Release form: Firm dosage forms. Tablets.

Indications to use: Parkinson's disease. Parkinsonism. Tremor. Neuralgia. Prevention of flu.


General characteristics. Structure:

Active ingredient: 100 mg of an amantadin (in the form of a hydrochloride) in each tablet.

Excipients: lactose (sugar milk), potato starch, talc, stearic acid, quinolinic yellow.




Pharmacological properties:

Pharmacodynamics. Protivoparkinsonichesky and antiviral means, tricyclic symmetric adamantanamine.

Blocks glutamate NMDA receptors (N - methyl - D - aspartatnye receptors) and by that reduces the excessive stimulating influence of cortical glutamate neurons on a neostriatum developing against the background of insufficiency of a dopamine. Amantadin oppresses NMDA receptors of neurons of black substance, reduces receipt in them of Ca2+ that reduces a possibility of destruction of the specified neurons. More influences constraint (rigidity and a bradykinesia).

Inhibits penetration of an influenza virus of A into a cell.

Pharmacokinetics. After intake it is completely absorbed from digestive tract. The maximum concentration of medicine in a blood plasma is reached in 5 h. It is removed with urine.


Indications to use:

Parkinson's disease, parkinsonism syndrome (rigidity, tremor, hypokinesia).

Neuralgia at the shingles caused by the Varicella zoster virus.

Prevention (including in combination with vaccination) and treatment of flu A.


Route of administration and doses:

Appoint inside after food. Accept, since 0,05 - 0,1 g, at first 2 times, then 3-4 times a day. Daily doses of 0,2 - 0,4. Duration of a course of treatment is 2 - 4 months.

Drug is appointed independently and in combination with other protivoparkinsonichesky means: cholinolytics and L-of a dof.

Maximum dose: at intake - 0,6 g/days.


Features of use:

At pregnancy use of an amantadin is possible only according to strict indications and under observation of the doctor.

In case of need uses in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

With care apply at patients with renal failures, at simultaneous use with other protivoparkinsonichesky means, and also at elderly people. In such cases correction of the mode of dosing of an amantadin is required. At patients with a hyperreflexia cancellation of treatment should be carried out gradually.

Data on efficiency of an amantadin for reduction of extrapyramidal frustration at treatment by antipsychotic means (medicinal parkinsonism) are contradictory.

During treatment not to allow alcohol intake.

During treatment it is not necessary to be engaged in the types of activity demanding high concentration of attention and bystry psychomotor reactions.


Side effects:

From TsNS: headaches, a depression, visual hallucinations, motive or a hyperphrenia, spasms, irritability, dizziness, frustration of a dream, the tremor, mental disorders which are followed by visual hallucinations, decrease in visual acuity.

From cardiovascular system: development or aggravation of heart failure, orthostatic hypotension; seldom - arrhythmia, tachycardia.

From the alimentary system: seldom - anorexia, nausea, locks, dryness in a mouth.

From an urinary system: patients with a hyperplasia of a prostate have a difficulty of an urination; polyuria, nocturia.

Dermatological reactions: dermatosis, emergence of bluish coloring of skin of upper and lower extremities (livedo reticularis).


Interaction with other medicines:

At simultaneous use strengthening of side effect of protivoparkinsonichesky means is possible.

At simultaneous use with thiazide diuretics it is impossible to exclude a possibility of development of toxic effects of an amantadin (an ataxy, excitement, hallucinations) probably owing to reduction of its renal clearance.

The case of acute confusion of consciousness at the patient of advanced age at simultaneous use with co-trimoxazole is described.

At simultaneous use with quinine, quinidine reduction of removal of an amantadin with urine is possible.

Precautionary measures

At pregnancy use of an amantadin is possible only according to strict indications and under observation of the doctor.

In case of need uses in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.


Contraindications:

Liver failure, chronic renal failure, psychoses (including in the anamnesis), a thyrotoxicosis, epilepsy, closed-angle glaucoma, a prostate hyperplasia, arterial hypotension, chronic heart failure of the II-III stage, a condition of excitement, a predelirium, delirious psychosis, the I trimester of pregnancy, the lactation period, a concomitant use of Triamterenum and hydrochlorothiazide, hypersensitivity to an amantadin.



Storage conditions:

List B. In the place protected from moisture, at a temperature not over 25 ºС. To store in the place, unavailable to children. A period of validity - 5 years. Not to use after the termination of a period of validity.


Issue conditions:

According to the recipe


Packaging:

On 10 tablets in a blister strip packaging; in packaging No. 10x5; on 100 tablets in a glass jar, in packaging No. 1.



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