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Deksametazon-MEZ

Препарат Дексаметазон-МЭЗ. ФГУП "Московский эндокринный завод" Россия


Producer: Federal State Unitary Enterprise Moscow Endocrine Plant Russia

Code of automatic telephone exchange: H02AB02, S01BA01

Release form: Liquid dosage forms. Drops are eye.

Indications to use: Allergic conjunctivitis. Keratitis. Keratoconjunctivitis. Iritis. Iridocyclitis. Blefarokonjyunktivit. Blepharitis. Episcleritis. Sclerite. Sympathetic ophthalmia. Cornea burn.


General characteristics. Structure:

Active ingredient: 1 mg of dexamethasone of sodium (in the form of phosphate).

Excipients: boric acid, pyroborate sodium decahydrate (sodium tetraborate 10-water), a benzetoniya chloride, dinatrium эдетат (disodium salt of ethylene diamine tetraacetic acid), 1 M hydroxide sodium solution to pH 7,4-7,8, the water purified.




Pharmacological properties:

Pharmacodynamics. Dexamethasone - the synthetic fluorinated glucocorticosteroid. Renders antiinflammatory, antiallergic, antiexudative and antipruritic action. Reduces permeability of vessels, slows down migration of leukocytes, phagocytosis, release of kinin, antibody formation. Antiinflammatory effect of drug is 25 times stronger than action of a hydrocortisone.

Pharmacokinetics. After an instillation in an eye well gets into a cornea epithelium, therapeutic concentration in watery moisture of an eye are reached. About 60-70% of the dexamethasone coming to a system blood stream contact proteins of a blood plasma. Dexamethasone at system absorption is metabolized in a liver under the influence of cytochromium enzymes, metabolites are removed through intestines. The elimination half-life averages 3 h.

Duration of local antiinflammatory action after an instillation of 1 drop of solution in a conjunctival sac makes from 4 to 8 h.


Indications to use:

Not purulent and allergic conjunctivitis, keratitis, keratoconjunctivitis without damage of an epithelium of a cornea, an iritis, an iridocyclitis, blefarokonjyunktivit, a blepharitis, an episcleritis, a sclerite, an inflammation after an injury of an eye and operative measures, a sympathetic ophthalmia, recovery of transparency of a cornea and suppression of neovascularization after a keratitis, burns (after full epithelization of a cornea).


Route of administration and doses:

To dig in in a conjunctival sac of the affected eye on 1 drop of 3-5 times a day.

The number of instillations depends on expressiveness of inflammatory process.

At the expressed inflammation drug can be used on doctor's orders up to several weeks.


Features of use:

Pregnancy and lactation. Use for pregnant women and nursing mothers is possible only to destination the attending physician if the expected medical effect exceeds risk of development of possible side effects.

At appointment as a sick herpetic keratitis it must be kept in mind a possibility of perforation of a cornea.

During treatment (lasting more than two weeks) it is necessary to control the intraocular pressure and a condition of a cornea.

At an instillation soft contact lenses need to be removed, again it is possible to put on them not earlier than in 15-20 min.

Treatment by drug can mask a picture of a bacterial or fungal infection therefore at treatment of infectious diseases of eyes drug should be combined with adequate antimicrobic therapy.

Influence on ability to manage vehicles and mechanisms. Within 30 min. after instillation it is necessary to abstain from the occupations requiring special attention.


Side effects:

Prolonged use of drug can lead to increase in side effects.

From organs of sight: back subkapsulyarny cataract; at a keratitis with a keratohelcosis thinning and perforation of a cornea, development of consecutive infection of eyes, local allergic reactions can be observed; increase in intraocular pressure that can lead to development of glaucoma with damage of an optic nerve, and also decrease in visual acuity and loss of fields of vision.

From cardiovascular system: arrhythmias, bradycardia, increase in arterial pressure.

From a nervous system: nervousness, sleeplessness, dizziness, headache, increase in intracranial pressure.

From the alimentary system: nausea, vomiting, increase or loss of appetite, exacerbation of chronic diseases of digestive tract.


Interaction with other medicines:

At prolonged use with idoksuridiny strengthening of destructive processes in a cornea epithelium is possible.


Contraindications:

Viral, tubercular and fungus diseases of eyes, acute form of a purulent infection in the absence of specific therapy, the cornea diseases which are followed by damage of integrity of a cornea, hypersensitivity, glaucoma. Children's age up to 18 years.

With care. Pregnancy, lactation period.


Overdose:

Strengthening of side effects is possible. Drug is cancelled.

Symptomatic treatment.


Storage conditions:

In the place protected from light, at a temperature from 12 to 15 °C. To store in the places unavailable to children. A period of validity - 2 years, after opening of a bottle - 1 month. Not to apply after the period of validity specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Drops are eye, 0,1%. Packaging: in a tube droppers on 1,3 ml 1,5 ml, 2 ml or 5 ml or in bottles on 5 ml. On the 5th tube droppers with the application instruction of drug and the application instruction a tube dropper in a pack from a cardboard. 1 bottle with a sterile cover dropper and the application instruction of drug in a pack from a cardboard.



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