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Kremgen

Препарат Кремген. СП ООО "Сперко Украина" Украина



General characteristics. Structure:

Active ingredients: флуоцинонид, gentamycin; 100 g of ointment contain: a fluotsinonida of 0,05 g, Gentamycini sulfas of 0,1 g in terms of gentamycin; excipients: propylene glycol, stearyl alcohol, polyethyleneglycol 4000, glycerin, citric acid, диметикон. Main physical and chemical properties: ointment of white color with a nacreous or nacreous-yellowish shade.




Pharmacological properties:

Pharmacodynamics. The combined drug for external use containing a glucocorticosteroid флуоцинонид and an aminoglikozidny antibiotic gentamycin. Effect of drug is caused by synergistic effects of the components which are its part.

Fluotsinonid — a synthetic highly effective glucocorticosteroid of the III generation. Possesses the expressed and long antiinflammatory, antiallergic, antiedematous and antipruritic action. Stabilizes membranes of lysosomes, inhibits a lizosomalny phospholipase of A2 that leads to reduction of formation of mediators of an inflammation of eicosanoids, cytokines (SILT-1 and 2, γ-interferon, TNF-α, etc.), blocks the cascade of transformation of arachidonic acid into prostaglandins, prevents cellular disintegration during inflammatory process. Stimulation of steroid receptors leads to formation of a special class of proteins — the lipokortin possessing antiedematous action.

The Aminoglikozidny antibiotic of the II generation gentamycin possesses the expressed bactericidal action. The mechanism of its antimicrobic activity consists in linkng with 30S-subunit of ribosomes of microorganisms that causes irreversible oppression of synthesis of protein. Gentamycin is fixed on cytoplasmic membranes of bacteria, breaks their permeability, leads to loss by cells of potassium ions, amino acids, nucleotides. Gentamycin works bakteritsidno in relation to Streptococcus spp., Staphylococcus spp. (including MRSA), Pseudomonas spp., Escherichia coli, Proteus spp., Klebsiella spp., Shigella spp., Salmonella spp., Enterobacter spp., Acinetobacter spp. and to other bacteria.

Pharmacokinetics. Drug components at topical administration easily get into all layers of skin, including into sites with inflammatory, erosive and burn processes, having therapeutic effect. At contact with a derma флуоцинонид it deetirifitsirutsya, releasing флуоцинолон which also shows strong glucocorticoid action. Thanks to effect of a deetirifikation at topical administration флуоцинонид practically does not get to a system blood stream. The molecule of gentamycin is characterized by sharply hydrophilic properties therefore does not get through biological membranes such as skin, an intestines wall, and does not get to a system blood stream at topical administration.


Indications to use:

The inflammatory and allergic diseases of skin including complicated by a consecutive bacterial infection: eczema of various forms and localization, dermatitis (atopic, contact, allergic, seborrheal, radiation, intertriginozny, exfoliative, solar), psoriasis, an anogenitalny and senile itch, red flat deprive, a diskoidny lupus erythematosus, trophic ulcers, burns and frostbites of skin of the I degree, stings of insects and arthropods.


Route of administration and doses:

Drug is applied with a thin layer on affected areas of skin by 2-3 times a day. Duration of a course of treatment is defined by character of a course of a disease.


Features of use:

It is not necessary to use drug under an occlusive bandage, and also priporazheniye of mucous membranes of an oral cavity, nose, an eye. At emergence during treatment of local irritation, a fungal infection of skin or development of allergic reactions drug should be cancelled.

Use during pregnancy or feeding by a breast. It is possible to apply Kremgen during pregnancy or feeding by a breast in case the expected advantage for mother exceeds potential risk for a fruit.

Children. Kremgen appoint to children aged from 2 years.

Ability to influence speed of response at control of motor transport or during the work with other mechanisms. Kremgen does not influence the speed of psychomotor reactions.


Side effects:

In some cases at prolonged use of drug, as well as all local glucocorticosteroids, the burning sensation, an itch, irritation, a xeroderma, a folliculitis, a hypertrichosis, a hirsutism, emergence of striya, acne rash, hypopigmentation, a skin atrophy, perioral dermatitis, allergic contact dermatitis, fungal infections of skin is possible. Development of local and generalizirovanny manifestations of allergic reactions is not excluded.


Interaction with other medicines:

Are not known.


Contraindications:

Virus, fungal infections of skin, tuberculosis cutis, skin new growths, skin displays of syphilis, hypersensitivity to drug components. Children's age up to 2 years.


Overdose:

At prolonged or excessive use of local glucocorticosteroids, including a fluotsinonida, especially at children, the risk of development of system effects (secondary insufficiency of adrenal glands and emergence of symptoms of a hypercorticoidism) is not excluded. Symptoms of a hypercorticoidism are usually reversible. Prolonged topical administration of gentamycin can lead to growth of resistant fungal or bacterial microflora. Symptomatic treatment.


Storage conditions:

To store at a temperature not above +25 °C. To store in the place, unavailable to children.

Period of validity - 3 years. It is not necessary to use drug after the termination of the period of validity specified on packaging after the words "Use to …"


Issue conditions:

According to the recipe


Packaging:

Ointment on 15 g or 30 g in aluminum tubas with a varnish covering with membranes and the screwed covers in a cardboard pack.



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