Tserepro

General characteristics. Structure:

Active ingredient: 400 mg of a glitserilfosforilkholin of hydrate (sincaline of an alfostserat).

Excipients: глицерол, the water purified.

Structure of a cover of the capsule: gelatin, глицерол, sorbitol of 70% solution, the water purified нипагин, нипазол, titanium dioxide, dye ferrous oxide red (E172).

The drug improving behavioural, cognitive reactions, normalizing bioelectric activity of a brain, involution of a psychoorganic syndrome at patients during the posttraumatic period and with vascular pathologies of a brain.

Pharmacological properties:

Pharmacodynamics. The central holinostimulyator as a part of which 40,5% of metabolic protected sincaline contain (metabolic protection provides release of sincaline in a brain). At hit in an organism it is split under the influence of enzymes on sincaline and glycerophosphate: sincaline participates in biosynthesis of acetylcholine – one of the main mediators of nervous excitement; glycerophosphate is a predecessor of phospholipids (fosfaditilkholin) of a neural membrane. Provides synthesis of acetylcholine and fosfaditilkholin in neyronalny membranes, improves a blood stream and strengthens metabolic processes in the central nervous system, activates a reticular formation. Increases the linear speed of a blood-groove on the party of traumatic damage of a brain, contributes to normalization of spatio-temporal characteristics of spontaneous bioelectric activity of a brain; exerts positive impact on cognitive and behavioural reactions of patients with vascular diseases of a brain.

Improves functions of a brain, influencing pathogenetic factors of an involutional psychoorganic syndrome, changes phospholipidic structure of membranes of neurons and reduces cholinergic activity. Dozozavisimo stimulates allocation of acetylcholine; participating in phosphatidylsincaline synthesis (membrane phospholipid), improves synoptic transfer, plasticity of neyronalny membranes, function of receptors. Does not exert impact on a reproductive cycle and does not possess teratogenic and mutagen action.

Pharmacokinetics. Absorption – 88%, easily gets through a blood-brain barrier (at oral administration concentration in a brain – 45% of that in plasma). It is removed preferential easy, in the form of carbon dioxide (85%), and also kidneys and through intestines (15%).

Indications to use:

- the acute and recovery periods of a severe craniocereberal injury and ischemic stroke, the recovery period of a hemorrhagic stroke proceeding with focal polusharny symptomatology or symptoms of defeat of a brainstem;

- a psychoorganic syndrome against the background of degenerative and involutional changes of a brain;

- chronic insufficiency of cerebral circulation;

- cognitive frustration (disturbance of cogitative function, memory, confusion of consciousness, a disorientation, decrease in motivation, initiative and ability of concentration of attention) including at dementia and encephalopathy;

- senile pseudo-melancholy.

Route of administration and doses:

At acute states: inside on 0,8 g (2 capsules) in the morning and 0,4 g (1 capsule) in the afternoon within 6 months.

At chronicities: inside on 0,4 g (1 capsule) 3 times a day, are preferable to food. Duration of treatment makes 3-6 months.

Features of use:

When developing nausea after administration of drug it is necessary to reduce a dose.

Not influence on a possibility of driving of the car, work with the equipment.

Side effects:

Allergic reactions, nausea (owing to dopaminergic activation).

Interaction with other medicines:

It is not revealed.

Contraindications:

- hypersensitivity;

- pregnancy;

- lactation period.

Overdose:

Symptoms: dyspepsia.

Treatment: gastric lavage, reception of absorbent carbon, symptomatic therapy.

Storage conditions:

Drug should be stored in unavailable to children, protected from moisture and light and the place at a temperature not above 25 °C. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 14 capsules in a blister strip packaging, 1 strip packaging in a cardboard box.