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medicalmeds.eu Medicines The means operating on a nervous system. Darvilol

Darvilol

Препарат Дарвилол. ЗАО "Фармацевтическая фирма "Дарница" Украина


Producer: CJSC Pharmaceutical Firm Darnitsa Ukraine

Code of automatic telephone exchange: N05CB02

Release form: Liquid dosage forms. Drops.

Indications to use: Stenocardia. Neurosis. Phobic frustration. Cardialgia. Sleep disorders. Psychomotor excitement.


General characteristics. Structure:

The main physical and chemical svoystva:bestsvetny transparent liquid with a characteristic radio smell; structure: 1 ml contains 20 mg of ethyl ether of α-bromizovalerianovy acid (in recalculation for 100% substance), 18,26 mg of phenobarbital (bafetal), 1,42 mg of oil of a peppermint; excipients: alcohol of ethyl 96%, изовалериат potassium, the water purified.




Pharmacological properties:

Pharmacodynamics. The combined drug which pharmacological properties are caused by action of the components which are its part. Phenobarbital and α-bromizovalerianovy acid possess sedative, light sleeping pill effects, promotes decrease in excitability of TsNS, facilitate approach of a natural dream. Oil of a peppermint has reflex spasmolytic effect.

Pharmacokinetics. Phenobarbital is quickly absorbed from a digestive tract. About 30-60% contact proteins. It is distributed almost in all fabrics, metabolized in a liver, partially – by oxidation. About 30% of phenobarbital are removed with urine in not changed look. An elimination half-life (T1/2) – 48-144 hours. Phenobarbital induces liver monooxygenases owing to what process of metabolism of other medicines accelerates.

Oil of a peppermint is quickly soaked up from digestive tract. It is brought out of an organism in three ways: with expired air, through kidneys with urine, with bile. The main component of oil of a peppermint – menthol is transformed in a liver with formation of a conjugate with glucuronic acid which is brought out of an organism through kidneys.

Ethyl ether of α-bromizovalerianovy acid is soaked up in a system blood stream from a mucous membrane of an oral cavity and metabolized by a deesterifikation with formation of isovaleric acid.


Indications to use:

  • Neurosises with an acrimony;
  • the functional cardiac disturbances which are followed by pains in heart;
  • easy forms of stenocardia;
  • sensation of fear and condition of excitement;
  • backfilling disturbance;
  • enterospasms.

Route of administration and doses:

Before use it is easy to stir up a bottle. The bottle at an angle to a horizontal is recommended to arrange for formation of drops.

The dose is established individually. The adult usually appoint 20 drops with a small amount of water or on a sugar piece 3 times a day to food. At tachycardia or spasms of coronary vessels increase in a single dose drops is possible till 40-50.

To children from 6 years appoint till 3-15 drops 3 times a day.


Features of use:

In need of Darvilol's appointment in the period of a lactation it is necessary to stop feeding by a breast. The patients accepting drug should refrain from occupations potentially dangerous types of activity requiring special attention and bystry mental and motor reactions.

Long use of drug because of possible formation of dependence is not recommended.

With care it is necessary to appoint Darvilol at hypotension.


Side effects:

Drug is usually well transferred. Slight dizziness, drowsiness, nausea, allergic reactions are in some cases possible.


Interaction with other medicines:

At simultaneous use of Darvilol and means, the oppressing TsNS, perhaps mutual strengthening of effects.

The phenobarbital which is a part of drug strengthens effect of valproic acid, weakens action of derivatives of coumarin, glucocorticoids, griseofulvin, peroral contraceptives; increases toxicity of a methotrexate.


Contraindications:

  • Hypersensitivity to drug components;
  • the expressed renal failures and/or a liver;
  • pregnancy;
  • age up to 6 years.

Overdose:

At acute poisonings easy and moderate severity confusion of consciousness, drowsiness are noted, up to a deep sleep. In hard cases of poisoning breath disturbance, tachycardia, arrhythmias, arterial hypotension, decrease in reflexes, a lump develop.

Treatment: the gastric lavage is carried out, adsorbents, an intensive care are appointed. The artificial diuresis, a hemodialysis are effective.


Storage conditions:

Store in protected from light and the place, unavailable to children, at a temperature not above 25 °C.

Period of validity – 2 years 6 months, from the date of production.


Issue conditions:

Without recipe


Packaging:

On 25 ml or 40 ml in a bottle, on 1 or 2 bottles in a pack.



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