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medicalmeds.eu Medicines Drugs which are used at joint pains and muscles. Ibuprofen

Ibuprofen

Препарат Ибупрофен. ООО «Фармтехнология» Республика Беларусь


Producer: LLC Pharmtekhnologiya Republic of Belarus

Code of automatic telephone exchange: M01AA13

Release form: Soft dosage forms. Cream.

Indications to use: Miositis. Rheumatic miositis. Bruises. Sprains. Rheumatic diseases. Hypostases. Bursitis. Tendinitis. Tendovaginitis. Ligament injuries.


General characteristics. Structure:

Active ingredient: 50 mg of an ibuprofen in 1 g of cream.

Excipients: a macrogoal 1500, paraffin soft, white, paraffin liquid, cetostearyl alcohol, a macrogoal cetostearyl ether, a makrogolglitserin hydroxystearate, stearic acid, diethanol amide, methylparahydroxybenzoate, пропилпарагидроксибензоат, citric acid monohydrate, the water purified.

The non-steroidal anti-inflammatory drug having anesthetic and antiinflammatory effect.




Pharmacological properties:

Pharmacodynamics. The ibuprofen is nonsteroid, anti-inflammatory drug, has the anesthetic and antiinflammatory effect caused by oppression of biosynthesis of prostaglandins by cyclooxygenase enzyme inhibition.

Pharmacokinetics. At external use the ibuprofen is soaked up through skin and gets to the inflammation center. The effect occurs in 30 minutes and several hours last. In joint fabrics therapeutic concentration keep within several hours.

In blood serum active ingredient makes only insignificant quantity therefore has no the expressed systemic action on an organism. Biological transformation of an ibuprofen happens in a liver. Products of metabolic disintegration are brought out of an organism by kidneys. The period of plasmatic elimination makes 1,8-3,5 hours.


Indications to use:

Drug is intended for external use at treatment: posttraumatic inflammations of sinews, muscles and joints (bruises, contusions, stretchings) at sports and other injuries; inflammatory rheumatic diseases of joints and backbone; hypostasis and an inflammation of soft tissues near the injured joints (at a bursitis, a tendinitis, a tendovaginitis, a latent injury and the joint capsule).


Route of administration and doses:

Cream is applied by 3 – 4 times a day on 1-4 g (a strip of cream of 4-10 cm) with a uniform thin layer on an affected area, slightly rubbing in skin.

Duration of treatment depends on disease severity and the nature of damage. In most cases treatment term drug makes 1-2 weeks. Not to apply an occlusive bandage.


Features of use:

Cream should not be applied on open wounds or mucous membranes. The contact with eyes is not allowed. Right after use of medicine it is necessary to wash up hands. When developing skin rash use of cream should be stopped immediately. At patients, patients is asthma, hay fever, chronic diseases of lungs and patients with hypersensitivity to analgetics and antirheumatic drugs have a big risk of development of asthmatic attacks, hypostases of a mucous membrane or a small tortoiseshell, than at other patients. Use of drug for these patients needs to be carried out under control of the doctor. It is necessary to use with care drug to patients with hypersensitivity (allergy) to other substances causing irritation of skin, an itch, urticaria. With care use drug at associated diseases of kidneys.

Use during pregnancy and feeding by a breast. There is no experience of use of cream for pregnant women and women during feeding by a breast therefore it is not necessary to use drug during these periods.

Influence on ability to manage motor transport or other mechanisms. There are no data on influence of an ibuprofen in the form of cream on ability to drive the car and to work with potentially dangerous equipment.

Children. Experience of use of drug for children up to 14 years is not enough therefore the ibuprofen in the form of cream is not applied in this age category.     


Side effects:

In rare instances erubescence, irritation of skin, burning sensation, an itch, urticaria, in rare instances - contact dermatitis can be observed, it is very rare - a bronchospasm at patients with the increased individual sensitivity to an ibuprofen. Prolonged use of cream on extensive sites of skin can cause systemic action of an ibuprofen.


Interaction with other medicines:

Interactions with other medicines at external use of drug are observed seldom. Drug can reduce diuretic effect of furosemide, strengthen effect of anticoagulants. Parallel use of aspirin or other NPVS can lead to increase in frequency of side reactions.


Contraindications:

- hypersensitivity to components of medicine and other non-steroidal anti-inflammatory drugs;
- the becoming wet dermatosis;
- eczema;
- the infected grazes and wounds;
- period of pregnancy and lactation;
- children up to 14 years.


Overdose:

At overdose the side effects observed at system use of an ibuprofen can take place (the dispepsichesky phenomena: nausea, heartburn, vomiting, pain in epigastric area, a meteorism; skin allergic reactions, headache; dizziness, etc.). In these cases drug should be cancelled. At exceeding of the recommended dose it is necessary to wash away cream water.


Storage conditions:

To store in the place protected from light at a temperature not above +25 °C. To store in the place, unavailable to children. Period of validity 2 years.


Issue conditions:

Without recipe


Packaging:

On 30,0 g and 50,0 g in the tubas placed together with a leaf insert on use in packs from a cardboard.



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