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medicalmeds.eu Medicines Anti-inflammatory drug for topical administration Apizartron

Apizartron

Препарат Апизартрон. Esparma GmbH (Эспарма ГмбХ) Германия


Producer: Esparma GmbH (Esparma Gmbh) Germany

Code of automatic telephone exchange: M02AC

Release form: Soft dosage forms. Ointment.

Indications to use: Neuralgia. Neuritis. Radiculitis. Ischialgia. Mialgiya. Musculoskeletal system injuries. Sprains. Ligament injuries. Osteoarthrosis (Остеоартит). Rheumatic diseases.


General characteristics. Structure:

Active ingredients: 3 mg of apitoxin, 10 g of methyl salicylate, 1 g of allyl isothiocyanate.

Excipients: sodium lauryl sulfate, white vaseline, the emulsified cetostearyl alcohol as a part of which contains: sodium cetylstearylsulphate, cetostearyl alcohol, water.




Pharmacological properties:

Pharmacodynamics. The combined medicine for external use on the basis of high cleaning apitoxin.

Apitoxin has anesthetic and antiinflammatory effect (stabilizes lizosomalny membranes), shows antibacterial influence (growth of gram-positive bacteria oppresses).

Methyl salicylate concerns to group of non-steroidal anti-inflammatory drugs, possesses the expressed antiinflammatory action (slows down production of prostaglandins, oppresses cyclooxygenase).

Allyl isothiocyanate (the purified standardized extract of mustard oil) causes deep warming up of fabrics, improves a local blood stream, lowers tonic contraction of muscles.


Indications to use:

• the diseases of a peripheral nervous system which are followed by feeling of pain: neuralgia, neuritis, radiculitises, pains in lumbar area (ischialgia);
• pains in muscles (mialgiya) and defeats of soft tissues, including caused by an injury;
• a warming up of muscles to, in time and after exercise stresses and sports activities;
• the damages/strained muscles which are followed by pain and hypostasis;
• musculoskeletal system diseases (osteoarthrosis, rheumatic defeat of soft tissues), degenerative and dystrophic defeats and joint pains.


Route of administration and doses:

Outwardly. Evenly to distribute a strip of ointment 3 - 5 cm long on skin (thickness of a layer about 1 mm) before emergence of reddening and a caumesthesia (2-3 minutes). After that slowly and intensively to rub ointment in skin.

For strengthening of medical action it is recommended to support the processed places in heat. To apply 2-3 times a day before disappearance of symptoms (no more than 10 days).


Features of use:

At a renal failure it is not necessary to allow prolonged use on big surfaces. It is not necessary to apply on the injured and angry skin. Not to allow contact of ointment with eyes, mucous membranes and open wounds. After putting ointment of a hand it is necessary to wash up carefully with soap.


Side effects:

Skin allergic reactions, irritation on site of application are in rare instances possible.


Interaction with other medicines:

Methyl salicylate strengthens effect of anticoagulants, a methotrexate.


Contraindications:

Hypersensitivity to apitoxin, salicylates, isothiocyanate; heavy chronic renal failure; liver failure; skin diseases; new growths; injuries of skin; acute arthritis; infectious diseases; oppression of a marrowy hemopoiesis; mental diseases; children's age (up to 6 years); pregnancy and period of a lactation.

With care. Renal failure, children's age from 6 to 12 years.



Storage conditions:

To store at a temperature not above 25 °C. To store in the place, unavailable to children! A period of validity - 3 years. Not to use after a period of validity!


Issue conditions:

According to the recipe


Packaging:

On 20 or 50 g of ointment for external use in tubas aluminum, soldered by aluminum foil and closed by a plastic cap. One tuba together with the application instruction is placed in a cardboard pack.



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