Gynofortum

General characteristics. Structure:

Active agent: butokonazola nitrate of 20 mg.

Excipients: sorbitol, oil mineral, glyceryl monostearate, polyglyceryl-3-oleate, wax, silicon dioxide colloid, dinatrium эдетат, methylparahydroxybenzoate, пропилпарагидроксибензоат, propylene glycol, water.

Pharmacological properties:

Pharmacodynamics. Butokonazol, derivative an imidazole, has fungicidal activity against mushrooms of Candida, Trichophyton, Microsporum, Epidermophyton. It is most effective at candidiases. Blocking in a cellular membrane formation of ergosterol from a lanosterol, increases permeability of a membrane that leads to a lysis of a cell of a mushroom.
Vaginal cream is an emulsion like "water in oil" therefore gives bioadhesive property to the carrier of a butokonazol (adhesion (Latin of adhaesio — sticking) - coupling of surfaces diverse firm and/or liquids. Adhesion is caused by intermolecular interactions in a blanket. Bioadhesion leads to increase in bioavailability and duration of effect of medicinal substance). At intravaginalny use бутоконазол is on a mucous membrane of a vagina within 4-5 days.

Pharmacokinetics. Cream has high bioadhesive property. At intravaginalny introduction 1,7% of the entered dose are absorbed the Maximum concentration in blood is reached in 13 h and makes 2-18,6 ng/ml. Butokonazol is exposed to intensive metabolism, is partially brought through intestines and kidneys.

Indications to use:

 The vagina candidiasis caused by Candida albicans.

Route of administration and doses:

Intravaginalno.
Treatment consists of single use of contents of one applicator (about 5 g) entered into a vagina at any time.
In case of a persistirovaniye of symptoms of a disease it is necessary to repeat a mycologic research.
Instructions on use of the applicator:

- To remove a foil from packaging and to take the applicator. Not to delete the special cap placed on the applicator. Strong holding the applicator with one hand and having pulled another for a ring, to extend from the applicator the piston to a limit.
- The applicator is intended for single use. It is impossible to use the applicator if the cap is removed. It is impossible to heat the applicator before use.
- To carefully enter the applicator as it is possible more deeply in a vagina.
- Slowly pressing on the piston, to squeeze out cream from the applicator.
- To remove the empty applicator from a vagina and to throw out it.

Features of use:

If clinical signs of an infection remain after completion of treatment, it is necessary to conduct a repeated mycologic research for identification of the activator and confirmation of the diagnosis.
Emergence of irritation of a mucous membrane of a vagina or painful feelings serves as the indication to the treatment termination as Ginofort® cream. At accidental hit of the drug Ginofort® in digestive tract it is necessary to make a gastric lavage and to carry out a symptomatic treatment.
To apply with care as the parabens capable to cause allergic reaction are a part of drug.

Influence on ability to driving of the car and to control of mechanisms.
Use of the drug Ginofort® does not influence ability to driving of the car and control of mechanisms.

Side effects:

Burning, itch, morbidity also swelled vagina walls, pains/spasms in the lower part of a stomach.

Interaction with other medicines:

Ginofort® cream contains the mineral oil damaging products from latex or rubber (including condoms or intra vulval diaphragms) therefore within 72 hours after use of Ginoforta® it is not recommended to use the above-stated contraceptives. It is necessary to use other methods of contraception.

Contraindications:

Hypersensitivity to any of drug components. Periods of pregnancy and lactation. Children's age up to 18 years (efficiency and safety are not established).

Overdose:

The drug Ginofort® cream is intended for intravaginalny use. About overdose by drug it was not reported.

Storage conditions:

At a temperature from 15 to 25 °C.
To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

Cream of vaginal 2%:
On 5 g of drug in the polypropylene applicator. Each applicator is placed in a polisterolovy case and then packed into the laminated package.
The package together with the instruction on a medical use is placed in a cardboard pack.