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medicalmeds.eu Medicines Expectorant mucolytic means. Ambroksol-Hemofarm

Ambroksol-Hemofarm

Препарат Амброксол-Хемофарм. Hemofarm, A.D. (Хемофарм А.Д.) Сербия


Producer: Hemofarm, A.D. (A.D. Hemofarm) Serbia

Code of automatic telephone exchange: R05CB06

Release form: Firm dosage forms. Tablets are sparkling.

Indications to use: Chronic bronchitis. Acute bronchitis. Pneumonia. Chronic obstructive diseases of lungs. Bronchial asthma. Bronchoectatic disease.


General characteristics. Structure:

Active agent: Ambroxol hydrochloride of 60 mg.

Excipients: the benzoic acid, глицерол 85%, sorbitol of 70%, hydroxyethylcellulose 6000 мПас (gietilloza), fragrance crimson, the water purified.




Pharmacological properties:

Mucolytic means, stimulates prenatal development of lungs (increases synthesis, secretion of surfactant and blocks its disintegration). Possesses sekretomotorny, sekretolitichesky and expectorant action; stimulates serous cells of glands of a mucous membrane of bronchial tubes, increases the maintenance of a mucous secret and release of surfactant (surfactant) in alveoluses and bronchial tubes; normalizes the broken ratio of serous and mucous components of a phlegm. Activating the hydrolyzing enzymes and strengthening release of lysosomes from Clark's cells, reduces viscosity of a phlegm. Increases physical activity of a ciliary epithelium, increases mukotsiliarny transport. After intake action comes in 30 min. and continues during 6-12 h.

Pharmacokinetics. Absorption - high, Cmax in a blood plasma - in 2 h, communication with proteins of plasma - 80%. Gets through a blood-brain barrier (GEB), a placental barrier, it is allocated with breast milk.

It is metabolized in a liver, forms dibromantranilovy acid and glucuronic conjugates. T1/2 - 7-12 h. It is removed by kidneys: 90% in the form of water-soluble metabolites, in not changed look - 5%.

T1/2 increases at a heavy chronic renal failure, but does not change at an abnormal liver function.


Indications to use:

— respiratory diseases with allocation of a viscous phlegm;
— acute and chronic bronchitis;
pneumonia;
— chronic obstructive pulmonary disease;
bronchial asthma with difficulty of an otkhozhdeniye of a phlegm;
bronchoectatic disease.


Route of administration and doses:

Tablets are sparkling
1 or 1/2 tablets sparkling dissolve in a glass of water (200 ml). Tablets should not be swallowed, chewed and sucked in a mouth.

Adults and children are more senior than 12 years: in the first 2-3 days on 1/2 tablets sparkling (30 mg) 3 times/days or 1 tablets of 60 mg in the morning and 1/2 tablets (30 mg) in the evening; in the next days on 1/2 tablets sparkling (30 mg) 2 times/days. If necessary for strengthening of therapeutic effect in the first 2-3 days it is possible to appoint on 60 mg (1 tablets sparkling) 2 times/days.

More than 4-5 days without appointment of the doctor are not recommended to use drug.


Features of use:

It is not necessary to combine with the antibechic medicines complicating removal of a phlegm.


Side effects:

Allergic reactions: skin rash, small tortoiseshell, Quincke's disease; in some cases - allergic contact dermatitis, an acute anaphylaxis.

Seldom: weakness, a headache, diarrhea, dryness in a mouth and airways, a dieback, a rhinorrhea, a lock, a dysuria.
At prolonged use in high doses: gastralgia, nausea, vomiting.


Interaction with other medicines:

Combined use with antibechic medicines leads to difficulty of an otkhozhdeniye of a phlegm against the background of reduction of cough.
Increases penetration into a bronchial secret of amoxicillin, a tsefuroksim, erythromycin and doxycycline.


Contraindications:

— rare hereditary diseases, such as intolerance of a galactose, deficit of lactase or glyukozo-galaktozny malabsorption (for tablets sparkling);
a fenilketonuriya (for tablets sparkling);
— pregnancy (I trimester);
— children's age up to 12 years (a tablet sparkling);
— hypersensitivity to all components of drug.

With care: a liver failure, a renal failure, a peptic ulcer of a stomach and duodenum, pregnancy (II and the III trimester), the lactation period, children's age till 1 year (syrup).


Overdose:

Symptoms: nausea, vomiting, diarrhea, and other gastrointestinal frustration.
Treatment: artificial vomiting, a gastric lavage in the first 1-2 h after administration of drug; reception of fat-containing products.


Storage conditions:

List B. Tablets sparkling should be stored in the dry, protected from light place, at a temperature of 15 °C up to 25 °C.


Issue conditions:

Without recipe


Packaging:

Tablets sparkling 60 mg: 10, 20 or 40 pieces.



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