DE   EN   ES   FR   IT   PT


medicalmeds.eu Medicines Antigipoksantny means. Metagard

Metagard

Изображение отсутствует


Producer: Ipca Laboratories (Ipk Laboratoriya) India

Code of automatic telephone exchange: C01EB15

Release form: Firm dosage forms. Tablets.

Indications to use: Coronary heart disease. Prevention of attacks of stenocardia. Kokhleovestibulyarny neuritis (Vestibular neyronit). Dizziness. Sonitus. Decrease in hearing.


General characteristics. Structure:

Active agent: trimetazidina dihydrochloride of 20 mg.




Pharmacological properties:

The means normalizing power metabolism of the cells which underwent a hypoxia or ischemia. Prevents decrease in intracellular content of ATP, provides normal functioning of membrane ion channels, transmembrane transfer of potassium ions and sodium and preservation of a cellular homeostasis.
Trimetazidin slows down oxidation of fatty acids at the expense of the selection inhibition long-chain 3-ketoatsetil-KOA thiomanholes that leads to increase in oxidation of glucose and to recovery of interface between glycolysis and oxidizing decarboxylation and as it was shown, provides protection of a myocardium against ischemia. Switching of oxidation of fatty acids to oxidation of glucose is the cornerstone of anti-anginal action of a trimetazidin.
In pilot studies on animals it is shown what триметазидин supports power metabolism of heart and neurosensory bodies during the periods of episodes of ischemia; reduces the size of intracellular acidosis and extent of changes in the transmembrane ion flux arising at ischemia; lowers the level of migration and infiltration of polynuclear neutrophils in ischemic and reperfusion tissues of heart, reduces the amount of injury of a myocardium; at the same time does not exert impact on a hemodynamics.

Pharmacokinetics. Trimetazidin is quickly and almost completely absorbed mucous intestines. Bioavailability makes 90%. Cmax is reached during 2 h and makes (after single oral administration of 20 mg of a trimetazidin) about 55 ng/ml. Vd – 4.8 l/kg. Easily passes through gistogematichesky barriers. Linkng with proteins of plasma makes 16%.
T1/2 is 4.5-5 h. It is removed by kidneys (about 60% - in not changed look).


Indications to use:

Long therapy of an ischemic heart disease: prevention of attacks of stenocardia (monotherapy or as a part of a combination therapy); treatment of cochleovestibular disturbances of the ischemic nature (including dizziness, sonitus, hearing disorder); chorioretinal vascular disorders with an ischemic component.


Route of administration and doses:

Accept inside in a dose 40-60 mg/days, frequency rate of reception of 2-3 times/days. Duration of therapy is established individually, depending on a clinical situation.


Features of use:

Trimetazidin does not influence ability to driving of the car and performance of work, the psychomotor reactions demanding high speed.


Side effects:

Perhaps: allergic reactions (including skin rash, itch).
Seldom: nausea, vomiting, gastralgia.


Interaction with other medicines:

There are no data.


Contraindications:

Pregnancy, the period of a lactation (breastfeeding), hypersensitivity to a trimetazidin.

Use at pregnancy and feeding by a breast
Trimetazidin is contraindicated to use at pregnancy and in the period of a lactation (breastfeeding).


Overdose:

It is not described.


Storage conditions:

List B. In the dry place protected from light, at a temperature not above 25 °C. To store in the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

Tablets, film coated, 20 mg. On 10 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. 2, 3 or 6 blister strip packagings together with the application instruction place in a pack.



Similar drugs

Препарат ТРИМЕТАЗИДИН-БИОКОМ МВ . Ipca Laboratories (Ипка Лаборатории) Индия

TRIMETAZIDIN-BIOKOM OF MV

Antigipoksantny means.



Препарат Три-зидин М. Ipca Laboratories (Ипка Лаборатории) Индия

Tri-zidin M

Other means for treatment of heart diseases.



Препарат Тримектал® МВ. Ipca Laboratories (Ипка Лаборатории) Индия

Тримектал® MV

Antigipoksantny means.



Препарат Предуктал® MВ. Ipca Laboratories (Ипка Лаборатории) Индия

Предуктал® MB

Antigipoksantny means.



Препарат Тридуктан MB. Ipca Laboratories (Ипка Лаборатории) Индия

Triduktan MB

Other cardiological means. Trimetazidin.



Препарат Триметазидин-Тева. Ipca Laboratories (Ипка Лаборатории) Индия

Trimetazidin-Tev

Antigipoksantny means.



Препарат Триметазидин. Ipca Laboratories (Ипка Лаборатории) Индия

Trimetazidin

Antigipoksantny means.



Препарат Депренорм® МВ. Ipca Laboratories (Ипка Лаборатории) Индия

Депренорм® MV

Antigipoksantny means.



Trimetazidin of MV

Antigipoksantny means.



Препарат Тридукард МВ таб 35мг №60. Ipca Laboratories (Ипка Лаборатории) Индия

Tridukard of MV таб 35 mg No.

Antigipoksantny means.



Препарат Римекор. Ipca Laboratories (Ипка Лаборатории) Индия

Rimekor

Antigipoksantny means.



Препарат Ангиозил® ретард. Ipca Laboratories (Ипка Лаборатории) Индия

Ангиозил® ретард

Antigipoksantny means.



Препарат Триметазидин. Ipca Laboratories (Ипка Лаборатории) Индия

Trimetazidin

Antiagreganta. Antigipoksantny means.



Препарат Антистен MB. Ipca Laboratories (Ипка Лаборатории) Индия

MB anti-walls

Antigipoksantny means.



Препарат Кардазин-Здоровье, табл. по 20мг №30х2. Ipca Laboratories (Ипка Лаборатории) Индия

Kardazin-Zdorovye, the tab. on 20 mg No. 30kh

Other cardiological means. Trimetazidin.





  • Сайт детского здоровья