Regulaks Pikosulfat

General characteristics. Structure:

Active ingredient: 7,5 mg of sodium of a pikosulfat of monohydrate in 1 ml of solution (15 drops).

Excipients: sorbitol solution of 70% uncrystallizable — 651,4 mg; propylene glycol — 200 mg; the water purified — 308 mg.

Pharmacological properties:

Pharmacodynamics. Purgative. The active form of drug which is formed by hydrolysis under the influence of intestinal microorganisms directly excites nervous structures of an intestinal wall therefore advance of intestinal contents accelerates, absorption of electrolytes and water decreases. Action comes in 10–12 h after reception.

Pharmacokinetics. After intake it is not soaked up from a GIT and is not exposed to hepatoenteric circulation.

Indications to use:

- atonic lock;
- regulation of a chair (hemorrhoids, proctitis, anus cracks);
- preparation for surgeries, tool and X-ray inspections.

Route of administration and doses:

Inside, before going to bed. Depending on the gained effect, the dose at the subsequent receptions is increased or reduced. For adults: an initial dose — 13 drops, at obstipation — to 26 drops. For children 4 years are more senior: an initial dose — 5–8 drops. A course of treatment — 7 days.

Features of use:

It is not necessary to accept without medical control more than 7 days. Long-term reception often leads to strengthening of fixing of intestines.

At children it is necessary to apply only in coordination with the doctor.

For patients with a diabetes mellitus: is suitable for patients with diabetes; contains sugar substitutes; 1 ml corresponds to 0,03 XE.

Use at pregnancy and feeding by a breast. Contraindicated in the I trimester of pregnancy. Multiple dose of drug during II and III trimesters has to be carried out only after careful assessment of need and risks as there is no sufficient information about use of drug at pregnancy. With care - the lactation period.

Side effects:

Are possible: diarrhea, abdominal pains, abdominal distention, dehydration, disturbances of water and electrolytic balance, weakness, spasms, decrease in the ABP.

Interaction with other medicines:

Increase in sensitivity to cardiac glycosides is possible.

GKS, diuretics increase risk of development of electrolytic disturbances.

Antibiotics of a broad spectrum of activity reduce aperient effect.

Contraindications:

- hypersensitivity;
- intestinal impassability;
- the restrained hernia;
- acute inflammatory diseases of abdominal organs;
- peritonitis;
- abdominal pains (not clear genesis);
- bleedings from a GIT;
- metrorrhagia;
- cystitis;
- heavy dehydration;
- spastic lock;
- pregnancy (I trimester);
- children's age up to 4 years.

With care: lactation period.

Overdose:

Symptoms: see. "Side effects"; besides, at chronic overdose development of ischemia of a mucous membrane of a large intestine, a secondary hyper aldosteronism, urolithiasis, defeat of renal tubules is possible.

Treatment: gastric lavage, correction of disturbances of water and electrolytic balance, purpose of antispasmodics.

Storage conditions:

At a temperature of 15-25 °C. To store in the place, unavailable to children. Period of validity of 5 years. A period of validity after opening of a bottle - 6 months. Not to apply after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Drops for intake of 7,5 mg/ml. On 10, 20 or 50 ml of drug place in bottles from brown glass with a stopper dropper and the screwed-up cover of white color. Each bottle is placed in a pack cardboard.