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medicalmeds.eu Medicines Analgetics and antipyretics. Milistan for babies

Milistan for babies

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Producer: Mili Healthcare Ltd (Mili Helskere Ltd) Great Britain

Code of automatic telephone exchange: N02BE01

Release form: Liquid dosage forms. Syrup.

Indications to use: Hyper thermal syndrome (Fever). Teething. Dentagra. Mialgiya.


General characteristics. Structure:

Active ingredient: 125 mg of paracetamol in 5 ml of syrup.

Excipients: polyethyleneglycol 1500, methylparaben, propylparaben, sugar, citric acid, sodium citrate, dyes: senst yellow (color of the sun what to come), essence of the mixed fruit, the water purified.

The drug possessing anesthetic, febrifugal, antiinflammatory action.




Pharmacological properties:

Pharmacodynamics. Paracetamol has anesthetics, febrifugal properties. The mechanism of analgesic effect of paracetamol connected with suppression of biosynthesis of prostaglandins. Inhibiting cyclooxygenase, it interferes with formation of E2 and F2 prostaglandins which play an important role at perception of pain stimulations nociceptors and transfers of excitement to TsNS.

Paracetamol effectively inhibits cyclooxygenase in cells of TsNS and is much weaker in peripheral fabrics. The antipyretic effect of paracetamol is explained by inhibition of biosynthesis of prostaglandins directly in a hypothalamus which are mediators of the center of thermal control.

Pharmacokinetics. The pharmacokinetics of paracetamol is characterized by bystry absorption from a digestive tract, hypodispersion in fabrics, rather short elimination half-life. The maximum concentration in plasma is defined ordinary in 30 - 60 minutes after intake. It is shown within 5 hours after a single dose. Bioavailability of drug very high, to 90%. Extent of linkng with proteins makes 25 - 50%. Paracetamol is metabolized (to 80%) microsomal enzymes of a liver, it is removed by a glyukurirovaniye and sulphation, only 3% are removed by kidneys in steady-state condition.


Indications to use:

Feverish states at infectious and inflammatory diseases and pain of a different origin (at a teething, in ears, the main and a dentagra, in muscles).


Route of administration and doses:

The measured spoon on 5 ml is in the middle of packaging of Milistan for babies.

To children age up to 3 months: 2, 5 ml (60 mg) – or 10 mg on 1 kg of body weight;

From 3 months to 1 year: 2, 5 ml - 5 ml (60 - 125 mg);

from 1 year to 3 years: 5 ml – 7, 5 ml (125 - 185 mg);

from 3 to 6 years: 7, 5 ml - 10 ml (185 - 250 mg);

If necessary drug is appointed by each 4 hours, but no more than 4 times within 24 hours.

The maximum daily dose for children:

from 3 to 6 months (to 7 kg) – 350 mg;

from 6 months to 1 year (to 10 kg) – 500 mg;

from 3 to 6 years (to 22 kg) – 1000 mg;

from 6 to 9 years (to 30 kg) – 1500 mg.

The maximum duration of treatment – 5 – 7 days.


Features of use:

At prolonged use of drug perhaps damages of a liver, kidneys and system of a hemopoiesis.


Side effects:

In isolated cases in the child there can be allergic reactions (skin a rash).

Decrease in level of thrombocytes, anemia, renal colic, aseptic Piraeus, an intersticial syndrome is very seldom noted.


Interaction with other medicines:

Caffeine can strengthen analgetic effect of paracetamol. Paracetamol can strengthen effect of indirect anticoagulants, derivative coumarin, an indole. At simultaneous use with barbiturates, rifampicin, phenobarbital, alcohol considerably

the risk of a hepatotoxic action increases. It is necessary to be careful at simultaneous use of drug together with other means which contain paracetamol.


Contraindications:

Hypersensitivity of patients to paracetamol and other components of drug, a serious illness of a liver and kidneys, children's age up to 3 months.


Overdose:

Paracetamol in large doses has a hepatotoxic action.

Clinical and biochemical signs of damage of a liver are shown in 12 – 24 hours. To them increase in activity of a dehydrogenase, hepatic transaminase, increase in concentration of bilirubin and decrease in level of a prothrombin belong.

Overdose symptoms: anorexia, nausea, vomiting, abdominal pain, pallor of skin, encephalopathy.

Treatment: immediate hospitalization, a gastric lavage, introductions of N – Acetylcysteinum intravenously, methionine orally.

 


Storage conditions:

To store at the room temperature (15-25 °C) in protected from light and the place, unavailable to children. Period of validity 2 years. A period of storage of an open bottle – 90 days.


Issue conditions:

Without recipe


Packaging:

On 100 ml of syrup in a bottle, on 1 bottle with a measured spoon and the application instruction in a cardboard pack.



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