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medicalmeds.eu Medicines Blockers of calcium channels. Nitresan

Nitresan

Препарат Нитресан. PRO.MED.CS Praha a.s. (ПРО.МЕД.ЦС, Прага, a.o.) Чешская Республика


Producer: PRO.MED.CS Praha a.s. (Missile defense. MED.TSS, Prague, a.o.) Czech Republic

Code of automatic telephone exchange: C08CA08

Release form: Firm dosage forms. Tablets.

Indications to use: Arterial hypertension.


General characteristics. Structure:

Active agents: 10 mg, 20 mg of a nitrendipin.




Pharmacological properties:

Nitrendipin – a dihydropyridinic blocker of calcium channels of the II generation with high vascular selectivity which selectively suppresses penetration of Ca2 + in cells of smooth muscles of walls of blood vessels. Weakening tension of smooth muscles of vascular walls, causes a vazodilatation and a lowering of arterial pressure. Biological availability of a nitrendipin — 20 — 30%, an elimination half-life — 8 — 12 hours, is distinguished preferential with urine.


Indications to use:

Essential arterial hypertension.


Route of administration and doses:

The dose and duration of therapy are established by the doctor individually. Reception of 10 mg 2 times a day or 20 mg of 1 times a day is usually recommended, in case of need it is possible to raise gradually a dose to 20 mg 2 times a day. Not to exceed the maximum daily dose of 40 mg of a nitrendipin a day. At elderly patients and patients with the expressed abnormal liver function it is recommended to begin therapy with a dose of 10 mg of 1 times a day.


Features of use:

Grapefruit juice increases hypotensive action and emergence of some undesirable effects of a nitrendipin therefore during therapy it is impossible to drink grapefruit juice. Drug is photosensitive therefore it is necessary to store tablets in original packaging.


Side effects:

Palpitation, tachycardia, in an initiation of treatment stenocardia attacks, a headache, face reddening, peripheral hypostases. Less often: itch, urticaria, photosensitivity.


Interaction with other medicines:

Nitrendipin is metabolized by means of a tsitofrom of P‑4503A4. Rifampicin reduces effect of a nitrendipin. Beta-blockers or other hypotensive drugs can increase anti-hypertensive action of a nitrendipin. At combined use of digoxin it is necessary to consider increase in concentration of digoxin in plasma.


Contraindications:

Hypersensitivity to a nitrendipin or to other antagonists of calcium 1,4digidropiridonovogo of type, excipients, cardiogenic shock, a stenosis of the aortal valve of a heavy stage, an acute myocardial infarction, unstable stenocardia, pregnancy, the lactation period.

Children and teenagers up to 18 years.


Overdose:

There are no data on overdose.


Storage conditions:

To store in original packaging in protected from light and the place, unavailable to children, at a temperature not above 25 °C.


Issue conditions:

According to the recipe


Packaging:

20, 30, 50, 60, 100 tablets on 10 mg, 20 mg.



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